Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial.

Autor: Aman J; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Duijvelaar E; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Botros L; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Kianzad A; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Schippers JR; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Smeele PJ; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Azhang S; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; Department of Pulmonology, Haaglanden Medisch Centrum, The Hague, Netherlands., Bartelink IH; Department of Pharmacy, Amsterdam UMC, VUMC, Amsterdam, Netherlands., Bayoumy AA; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; Department of Pulmonology, Chest Unit, Suez Canal University, Suez, Egypt., Bet PM; Department of Pharmacy, Amsterdam UMC, VUMC, Amsterdam, Netherlands., Boersma W; Department of Pulmonology, Noordwest Ziekenhuisgroep, Alkmaar, Netherlands., Bonta PI; Department of Respiratory Medicine, Amsterdam UMC, AMC, University of Amsterdam, Amsterdam, Netherlands., Boomars KAT; Department of Pulmonology, Erasmus Medisch Centrum, Rotterdam, Netherlands., Bos LDJ; Department of Respiratory Medicine, Amsterdam UMC, AMC, University of Amsterdam, Amsterdam, Netherlands; Department of Intensive Care, Amsterdam UMC, AMC, Amsterdam, Netherlands., van Bragt JJMH; Department of Respiratory Medicine, Amsterdam UMC, AMC, University of Amsterdam, Amsterdam, Netherlands., Braunstahl GJ; Department of Pulmonology, Sint Franciscus Ziekenhuis, Rotterdam, Netherlands., Celant LR; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Eger KAB; Department of Respiratory Medicine, Amsterdam UMC, AMC, University of Amsterdam, Amsterdam, Netherlands., Geelhoed JJM; Department of Pulmonology Leiden University Medical Center, Leiden, Netherlands., van Glabbeek YLE; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Grotjohan HP; Department of Pulmonology, Isala Ziekenhuizen, Zwolle, Netherlands., Hagens LA; Department of Intensive Care, Amsterdam UMC, AMC, Amsterdam, Netherlands., Happe CM; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Hazes BD; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Heunks LMA; Department of Intensive Care, Amsterdam UMC, VUMC, Amsterdam, Netherlands., van den Heuvel M; Department of Pulmonology, Radboud UMC, Nijmegen, Netherlands., Hoefsloot W; Department of Pulmonology, Radboud UMC, Nijmegen, Netherlands., Hoek RJA; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Hoekstra R; Department of Pulmonology, Antonius Ziekenhuis, Sneek, Netherlands., Hofstee HMA; Department of Internal Medicine, Haaglanden Medisch Centrum, The Hague, Netherlands., Juffermans NP; Department of Intensive Care, Amsterdam UMC, AMC, Amsterdam, Netherlands; Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands., Kemper EM; Hospital Pharmacy, Amsterdam UMC, AMC, Amsterdam, Netherlands., Kos R; Department of Respiratory Medicine, Amsterdam UMC, AMC, University of Amsterdam, Amsterdam, Netherlands., Kunst PWA; Department of Pulmonology, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands., Lammers A; Department of Respiratory Medicine, Amsterdam UMC, AMC, University of Amsterdam, Amsterdam, Netherlands., van der Lee I; Department of Pulmonology, Spaarne Gasthuis, Haarlem, Netherlands., van der Lee EL; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Maitland-van der Zee AH; Department of Respiratory Medicine, Amsterdam UMC, AMC, University of Amsterdam, Amsterdam, Netherlands., Mau Asam PFM; Department of Respiratory Medicine, Amsterdam UMC, AMC, University of Amsterdam, Amsterdam, Netherlands., Mieras A; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Muller M; Department of Pulmonology, Catharina Ziekenhuis, Eindhoven, Netherlands., Neefjes ECW; Department of Pulmonology, Catharina Ziekenhuis, Eindhoven, Netherlands., Nossent EJ; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Oswald LMA; Department of Pulmonology, Sint Franciscus Ziekenhuis, Rotterdam, Netherlands., Overbeek MJ; Department of Pulmonology, Haaglanden Medisch Centrum, The Hague, Netherlands., Pamplona CC; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Paternotte N; Department of Pulmonology, Noordwest Ziekenhuisgroep, Alkmaar, Netherlands., Pronk N; Department of Pulmonology, Gelre Ziekenhuis, Apeldoorn, Netherlands., de Raaf MA; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., van Raaij BFM; Department of Pulmonology Leiden University Medical Center, Leiden, Netherlands., Reijrink M; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Schultz MJ; Department of Intensive Care, Amsterdam UMC, AMC, Amsterdam, Netherlands., Serpa Neto A; Department of Critical Care Medicine and Institute of Education and Research, Hospital Israelita Albert Einstein, São Paulo, Brazil., Slob EMA; Department of Respiratory Medicine, Amsterdam UMC, AMC, University of Amsterdam, Amsterdam, Netherlands., Smeenk FWJM; Department of Pulmonology, Catharina Ziekenhuis, Eindhoven, Netherlands., Smit MR; Department of Intensive Care, Amsterdam UMC, AMC, Amsterdam, Netherlands., Smits AJ; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Stalenhoef JE; Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands., Tuinman PR; Department of Intensive Care, Amsterdam UMC, VUMC, Amsterdam, Netherlands., Vanhove ALEM; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Wessels JN; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., van Wezenbeek JCC; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Vonk Noordegraaf A; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., de Man FS; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Bogaard HJ; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VUMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. Electronic address: hj.bogaard@amsterdamumc.nl.

Publikováno v: The Lancet. Respiratory medicine [Lancet Respir Med] 2021 Sep; Vol. 9 (9), pp. 957-968. Date of Electronic Publication: 2021 Jun 18.