Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ege Devries"'
Publikováno v:
Europe PubMed Central
Cancer Chemotherapy and Pharmacology, 51(2), 167-173. SPRINGER
Cancer Chemotherapy and Pharmacology, 51(2), 167-173. SPRINGER
Purpose: The influence of liver metastases on the pharmacokinetics of 5-fluorouracil (5-FU) and its metabolite 5,6-dihydrofluorouracil (DHFU) was studied in patients with liver metastases from gastrointestinal cancer (n = 16) and compared with a cont
Publikováno v:
Anti-Cancer Drugs. 8:413-418
Fostriecin is a novel antitumor antibiotic. In vitro studies showed that fostriecin inhibits DNA topoisomerase II (Topo II) catalytic activity, protein phosphatases involved with cell-cycle control and histone phosphatases. The relative contribution
Publikováno v:
British Journal of Cancer
British Jounal of Cancer, 76(11), 1480-1483. Nature Publishing Group
British Jounal of Cancer, 76(11), 1480-1483. Nature Publishing Group
Etoposide phosphate is a water-soluble prodrug of etoposide. It was expected that this prodrug could be used to overcome the solubility limitations and erratic bioavailability of oral etoposide. To investigate the possibility of prodrug conversion to
Autor:
J. A. Gietema, J. Boonstra, Ege Devries, Wta Vandergraaf, Nh Mulder, A. Cats, Dt Sleijfer, Gj Veldhuis, Phb Willemse, Dra Uges, Hj Guchelaar
Publikováno v:
British Journal of Cancer
In phase I studies, lobaplatin showed activity in ovarian cancer patients pretreated with platinum. A phase II trial with lobaplatin was performed in patients with refractory or relapsed ovarian cancer to define activity and pharmacokinetics. Twenty-
Publikováno v:
International Journal of Cancer. 61:722-726
Hyperthermia treatment (greater than or equal to 43 degrees C) has been shown to be able to (partially) reverse acquired cDDP resistance. However, such heat treatment is difficult to achieve in the clinic. Short pre-treatment at a high temperature (>
Publikováno v:
Anti-Cancer Drugs. 6:34-39
BW502U83, an arylmethylaminopropanediol (AMAP), showed to be partially cross-resistant in a P-glycoprotein-positive and in a P-glycoprotein-negative, doxorubicin-resistant cell line, while no cross-resistance was noticed in a cisplatin-resistant cell
Publikováno v:
Genes, Chromosomes and Cancer. 10:66-70
A malignant fibrous histiocytoma (MFH) of bone arising in the fibula of a 21-year-old woman is described. Clinical, radiologic, and histologic findings demonstrated rapid tumor progression. Chromosomal analysis of the biopsy specimen showed great kar
Autor:
Nh Mulder, Hj Guchelaar, Ege Devries, Edo Vellenga, Mt Esselink, Dra Uges, C. J. L. M. Meijer
Publikováno v:
Pharmaceutical Research. 11:1265-1269
The importance of the ultrafilterable platinum (fPt) fraction of cisplatin (CDDP) and carboplatin (CBDCA) for cytotoxicity and myelotoxicity was studied in vitro. By incubating CDDP or CBDCA with fetal calf serum (PCS) various fractions of fPt were p
Publikováno v:
International journal of oncology, 3(1), 47-51. SPANDIDOS PUBL LTD
The biotransformation activity of the mono-oxygenase enzyme, 7-ethoxycoumarin-O-deethylase (EOD), was investigated in the upper digestive tract of colon cancer patients, and compared with patients with and without neoplasia. The three groups studied
Publikováno v:
Anti-Cancer Drugs. 4:51-55
A phase I trial with continuous intravenous infusion of lobaplatin (D-19466; 1,2-diamminomethyl-cyclobutane-platinum (II)-lactate) for 72 h was performed to determine the maximum tolerated dose (MTD). Each patient received a single dose level, the to