Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Autor: Jo Vandesompele, Peter Nürnberg, Shantanu Banerji, Lukas C. Heukamp, Stefanie Heynck, Matthias Fischer, Daniel Rauh, Sylvie Lantuejoul, Ingelore Baessmann, Holger Moch, Matthew Meyerson, Reinhard Büttner, Kwon-Sik Park, Ines Wilkening, Steinar Solberg, Stefan A. Haas, Egber Smit, Dennis Plenker, Zoe Wainer, Prudence A. Russell, Ilona Dahmen, William Pao, Erik Thunnissen, C. Ligorio, Bram De Wilde, Paul K. Brindle, Diana Böhm, Vito Michele Fazio, Vincenzo Di Cerbo, Benjamin Solomon, Stefania Damiani, Walburga Engel-Riedel, Erich Stoelben, Corinna Ludwig, Hannie Sietsma, Daniëlle A M Heideman, Jürgen Wolf, Thomas Muley, Elisabeth Brambilla, Ruping Sun, Wim Timens, Jay Shendure, Laura Pasqualucci, Kristian Cibulskis, Julien Sage, Gavin M. Wright, Mirjam Koker, Pierre Validire, Danila Seidel, Johannes M. Heuckmann, Harry J.M. Groen, Christian Becker, Philippe Lorimier, Peter J.F. Snijders, Sven Perner, Michael Brockmann, Xin Lu, Franziska Gabler, Scott L. Carter, Marius Lund-Iversen, Lucia Anna Muscarella, Jörg Sänger, Benjamin Besse, Hans Ulrich Schildhaus, Frauke Leenders, John K. Field, Odd Terje Brustugun, Christian Brambilla, Philipp A. Schnabel, Sascha Ansén, Christian Grütter, Michael Hallek, Gad Getz, Yuan Chen, Roopika Menon, Roman K. Thomas, Joachim H. Clement, Janine Altmüller, Martin L. Sos, Hans Hoffmann, Peter M. Schneider, Julie George, Christian Müller, Iver Petersen, Federico Cappuzzo, Lawryn H. Kasper, Robert Schneider, Martin Peifer, Lynnette Fernandez-Cuesta, Jean-Charles Soria, Alex Soltermann, Thomas Zander, Walter Weder

Publikováno v: Nature Genetics
Nature Genetics, 44(10), 1104-1110. Nature Publishing Group
Peifer, M, Fernandez-Cuesta, L, Sos, M L, George, J, Seidel, D, Kasper, L H, Plenker, D, Leenders, F, Sun, R, Zander, T, Menon, R, Koker, M, Dahmen, I, Muller, C, Di Cerbo, V, Schildhaus, H U, Altmuller, J, Baessmann, I, Becker, C, de Wilde, B, Vandesompele, J, Bohm, D, Ansen, S, Gabler, F, Wilkening, I, Heynck, S, Heuckmann, J M, Lu, X, Carter, S L, Cibulskis, K, Banerji, S, Getz, G, Park, K S, Rauh, D, Grutter, C, Fischer, M, Pasqualucci, L, Wright, G, Wainer, Z, Russell, P, Petersen, I, Chen, Y, Stoelben, E, Ludwig, C, Schnabel, P, Hoffmann, H, Muley, T, Brockmann, M, Engel-Riedel, W, Muscarella, L A, Fazio, V M, Groen, H, Timens, W, Sietsma, H, Thunnissen, F B J M, Smit, E F, Heideman, D A M, Snijders, P J F, Cappuzzo, F, Ligorio, C, Damiani, S, Field, J, Solberg, S, Brustugun, O T, Lund-Iversen, M, Sanger, J, Clement, J H, Soltermann, A, Moch, H, Weder, W, Solomon, B, Soria, J C, Validire, P, Besse, B, Brambilla, E, Brambilla, C, Lantuejoul, S, Lorimier, P, Schneider, P M, Hallek, M, Pao, W, Meyerson, M, Sage, J, Shendure, J, Schneider, R, Buttner, R, Wolf, J, Nurnberg, P, Perner, S, Heukamp, L C, Brindle, P K, de Haas, S & Thomas, R K 2012, ' Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer ', Nature Genetics, vol. 44, no. 10, pp. 1104-1110 . https://doi.org/10.1038/ng.2396
Nature Genetics, 44(10), 1104-+. Nature Publishing Group
Nature Genetics; Vol 44

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis(1-3). We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4 +/- 1 protein-changing mutations per million bas

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https://doi.org/10.1038/ng.2396