Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction.

Autor: Wood GK; Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Sargent BF; Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK., Ahmad ZU; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Tharmaratnam K; Department of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, UK., Dunai C; Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Egbe FN; Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Martin NH; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Facer B; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Pendered SL; Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Rogers HC; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Hübel C; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; National Centre for Register-based Research, Aarhus Business and Social Sciences, Aarhus University, Aarhus, Denmark.; Department of Pediatric Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., van Wamelen DJ; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Parkinson's Foundation Center of Excellence, King's College Hospital, London, UK.; Department of Neurology; Centre of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands., Bethlehem RAI; Department of Psychology, University of Cambridge, Cambridge, UK., Giunchiglia V; Department of Brain Sciences, Imperial College London, London, UK., Hellyer PJ; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Trender W; Department of Brain Sciences, Imperial College London, London, UK., Kalsi G; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Needham E; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Easton A; Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Encephalitis International, Malton, UK., Jackson TA; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Cunningham C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Upthegrove R; Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK., Pollak TA; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; South London and Maudsley NHS Foundation Trust, London, UK., Hotopf M; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Solomon T; Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; The Pandemic Institute, University of Liverpool, Liverpool, UK.; Department of Neurology, Walton Centre Foundation Trust, Liverpool, UK., Pett SL; MRC Clinical Trials Unit, UCL, London, UK.; Institute of Clinical Trials and Methodology, UCL, London, UK.; Institute for Global Health, UCL, London, UK., Shaw PJ; Division of Neuroscience, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.; Sheffield Institute for Translational Neuroscience, NIHR Biomedical Research Centre, University of Sheffield, Sheffield, UK., Wood N; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, UCL, London, UK.; UCL Genetics Institute, Division of Biosciences, UCL, London, UK., Harrison NA; Cardiff University Brain Research Imaging Centre, School of Medicine, Cardiff University, Cardiff, UK., Miller KL; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK., Jezzard P; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK., Williams G; Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Duff EP; UK Dementia Research Institute, Department of Brain Sciences, Imperial College London, London, UK., Williams S; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Zelaya F; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; NIHR Maudsley Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust, London, UK., Smith SM; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK., Keller S; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Broome M; Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.; Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK., Kingston N; NIHR Bioresource, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Haematology, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Husain M; Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Department of Experimental Psychology, University of Oxford, Oxford, UK., Vincent A; Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford, UK., Bradley J; NIHR Bioresource, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Chinnery P; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Menon DK; Section of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Cambridge, UK., Aggleton JP; School of Psychology, Cardiff University, Cardiff, UK., Nicholson TR; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; South London and Maudsley NHS Foundation Trust, London, UK.; Neuropsychiatry Research and Education Group, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Taylor JP; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.; Old Age Psychiatry, Tyne and Wear NHS Trust, Newcastle, UK., David AS; Department of Psychiatry, Institute of Mental Health, UCL, London, UK., Carson A; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Bullmore E; Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Department of Psychiatry, Institute of Behavioural and Clinical Neuroscience, University of Cambridge, Cambridge, UK., Breen G; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; NIHR Maudsley Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust, London, UK., Hampshire A; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Michael BD; Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. benmic@liverpool.ac.uk.; NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. benmic@liverpool.ac.uk.; Department of Neurology, Walton Centre Foundation Trust, Liverpool, UK. benmic@liverpool.ac.uk., Paddick SM; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.; Department of Old Age Psychiatry, Gateshead Health NHS Foundation Trust, Gateshead, UK.; Millenium Institute for Care Research (MICARE), Santiago, Chile., Leek EC; Department of Psychology, Institute of Population Health, Institute of Life and Human Sciences, University of Liverpool, Liverpool, UK.; School of Psychology, University of Southampton, Southampton, UK.

Publikováno v: Nature medicine [Nat Med] 2024 Sep 23. Date of Electronic Publication: 2024 Sep 23.

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.

Autor: Michael BD; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK. benmic@liverpool.ac.uk.; NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool, Liverpool, L69 7BE, UK. benmic@liverpool.ac.uk.; The Walton Centre NHS Foundation Trust, Liverpool, L9 7BB, UK. benmic@liverpool.ac.uk., Dunai C; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.; NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool, Liverpool, L69 7BE, UK., Needham EJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Tharmaratnam K; Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, L69 3GF, UK., Williams R; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.; Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA., Huang Y; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK., Boardman SA; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK., Clark JJ; University of Liverpool, Liverpool, L69 7BE, UK.; Department of Microbiology, Icahn School of Medicine, Mount Sinai, NY, 10029, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VARPP), Icahn School of Medicine, Mount Sinai, NY, 10029, USA., Sharma P; Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L3 5RF, UK., Subramaniam K; Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L3 5RF, UK., Wood GK; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK., Collie C; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK., Digby R; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Ren A; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Norton E; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Leibowitz M; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Ebrahimi S; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Fower A; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK., Fox H; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK., Tato E; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; NIHR Maudsley Biomedical Research Centre, King's College London, London, SE5 8AF, UK., Ellul MA; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.; The Walton Centre NHS Foundation Trust, Liverpool, L9 7BB, UK., Sunderland G; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK., Held M; Centre for Cell Imaging, Liverpool Shared Research Facilities, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, L69 7ZB, UK., Hetherington C; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK., Egbe FN; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK., Palmos A; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; NIHR Maudsley Biomedical Research Centre, King's College London, London, SE5 8AF, UK., Stirrups K; NIHR BioResource, Cambridge University Hospitals NHS Foundation, Cambridge, CB2 0QQ, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0QQ, UK., Grundmann A; Clinical Neurosciences, Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, SO17 1BF, UK.; Department of Neurology, Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, UK., Chiollaz AC; Département de médecine interne des spécialités (DEMED), University of Geneva, Geneva, CH-1211, Switzerland., Sanchez JC; Département de médecine interne des spécialités (DEMED), University of Geneva, Geneva, CH-1211, Switzerland., Stewart JP; Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L3 5RF, UK., Griffiths M; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK., Solomon T; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.; NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool, Liverpool, L69 7BE, UK.; The Walton Centre NHS Foundation Trust, Liverpool, L9 7BB, UK.; The Pandemic Institute, Liverpool, L7 3FA, UK., Breen G; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.; NIHR Maudsley Biomedical Research Centre, King's College London, London, SE5 8AF, UK., Coles AJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Kingston N; NIHR BioResource, Cambridge University Hospitals NHS Foundation, Cambridge, CB2 0QQ, UK.; University of Cambridge, Cambridge, CB2 0QQ, UK., Bradley JR; NIHR BioResource, Cambridge University Hospitals NHS Foundation, Cambridge, CB2 0QQ, UK.; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Chinnery PF; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.; NIHR BioResource, Cambridge University Hospitals NHS Foundation, Cambridge, CB2 0QQ, UK., Cavanagh J; Centre for Immunology, School of Infection & Immunity, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Irani SR; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.; Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA., Vincent A; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK., Baillie JK; Roslin Institute, University of Edinburgh, Edinburgh, EH25 9RG, UK.; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, EH10 5HF, UK., Openshaw PJ; National Heart and Lung Institute, Imperial College London, London, SW7 2BX, UK.; Imperial College Healthcare NHS Trust, London, W2 1NY, UK., Semple MG; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.; NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool, Liverpool, L69 7BE, UK.; Respiratory Unit, Alder Hey Children's Hospital NHS Foundation Trust, Liverpool, L14 5AB, UK., Taams LS; Centre for Inflammation Biology and Cancer Immunology, King's College London, London, SE1 9RT, UK., Menon DK; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 22; Vol. 14 (1), pp. 8487. Date of Electronic Publication: 2023 Dec 22.