Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Egīls Bisenieks"'
Autor:
Brigita Vigante, Martins Rucins, Aiva Plotniece, Karlis Pajuste, Iveta Luntena, Brigita Cekavicus, Egils Bisenieks, Rufus Smits, Gunars Duburs, Arkadij Sobolev
Publikováno v:
Molecules, Vol 20, Iss 11, Pp 20341-20354 (2015)
The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions. The use of TBD is crucial for
Externí odkaz:
https://doaj.org/article/0eee7127df4b4de8bf1e72700caf66ed
Autor:
Lidija Milkovic, Tea Vukovic, Neven Zarkovic, Franz Tatzber, Egils Bisenieks, Zenta Kalme, Imanta Bruvere, Zaiga Ogle, Janis Poikans, Astrida Velena, Gunars Duburs
Publikováno v:
Antioxidants, Vol 7, Iss 9, p 123 (2018)
Oxidative stress has been implicated in pathophysiology of different human stress- and age-associated disorders, including osteoporosis for which antioxidants could be considered as therapeutic remedies as was suggested recently. The 1,4-dihydropyrid
Externí odkaz:
https://doaj.org/article/f4a5a96db1f94324bb2f78d96f667102
Autor:
Jānis Poikāns, Dzintra Stoldere, Egīls Bisenieks, Jānis Uldriķis, Māra Stivriņa, N. V. Makarova, Janīna Briede, Gunārs Duburs
Publikováno v:
Cell Biochemistry and Function. 22:219-224
Analysis of the effect of several 1,4-DHP Ca(2+) channel antagonists on experimental and clinical diabetes shows that structurally similar Ca(2+) channel antagonists can exert opposite effects on Ca(2+) influx, glucose homeostasis and insulin secreti
Publikováno v:
ChemInform. 29
Autor:
O. Yu. Pankov, M. N. Karpova, G. Tsebers, G. Ya. Duburs, V. E. Klusha, S. K. Germane, Egīls Bisenieks
Publikováno v:
Bulletin of Experimental Biology and Medicine. 116:1119-1121
Autor:
Jānis Poikāns, N. V. Makarova, Daina Daija, Gunārs Duburs, Janīna Briede, Egīls Bisenieks, Jānis Uldriķis
Publikováno v:
Cell biochemistry and function. 17(2)
Ca antagonists of different classes (verapamil, nifedipine, nicardipinc, diltiazem) in a concentration of 10(-5) M and higher are known to suppress Ca2+ transport into the lymphocyte cytosol, changing a normal response of lymphocytes to mitogens and
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells
Autor:
Jonna Tenhunen, Tomáš Kučera, Marjo Huovinen, Jenni Küblbeck, Egils Bisenieks, Brigita Vigante, Zaiga Ogle, Gunars Duburs, Martin Doležal, Ruin Moaddel, Maija Lahtela-Kakkonen, Minna Rahnasto-Rilla
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 138, Iss , Pp 111452- (2021)
Sirtuin 6 (SIRT6), a member of sirtuin family (SIRT1-7), regulates a variety of cellular processes involved in aging, metabolism, and cancer. Dysregulation of SIRT6 is widely observed in different breast cancer subtypes; however, the role and functio
Externí odkaz:
https://doaj.org/article/64ca3b992d4f4bdf97a28889ed4cf5f8
Autor:
Elina Leonova, Karlis Shvirksts, Vitalijs Borisovs, Edgars Smelovs, Jelizaveta Sokolovska, Egils Bisenieks, Gunars Duburs, Mara Grube, Nikolajs Sjakste
Publikováno v:
PeerJ, Vol 8, p e10061 (2020)
1,4-dihydropyridines (1,4-DHP) possess important biochemical and pharmacological properties, including antimutagenic and DNA-binding activity. The latter activity was first described for water-soluble 1,4-DHP with carboxylic group in position 4, the
Externí odkaz:
https://doaj.org/article/7b490761239d4603adce39940a5769d7
Autor:
Egils Bisenieks, Janis Poikans, Aiva Plotniece, Eiva Bernotiene, Wei-Bor Tsai, Arkadij Sobolev
Publikováno v:
Molbank, Vol 2020, Iss 3, p M1148 (2020)
The development of the methods for amide bond formation is important for various uses in the laboratory and industrial applications. The compounds combined in their structures 1,4-dihydroisonicotinic acids and amino acids linked with an amide bond ca
Externí odkaz:
https://doaj.org/article/9682750f638449be970c9dbb74d13a0a
Autor:
Anatoly Mishnev, Egils Bisenieks, Ilona Mandrika, Ramona Petrovska, Zenta Kalme, Imanta Bruvere, Gunars Duburs
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 11, Pp 1577-1579 (2018)
In the title compound, C25H25NO5S, which exhibits metabolism-regulating activity, the 1,4-dihydropyridine ring adopts a flattened boat conformation while the cyclohexenone ring is in an envelope conformation. Molecules in the crystal are assembled in
Externí odkaz:
https://doaj.org/article/3935d33eb2f34602b859ed3ce3165738