Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Autor: Antonio Dominguez-Meijide, Valeria Parrales, Eftychia Vasili, Florencia González-Lizárraga, Annekatrin König, Diana F. Lázaro, Annie Lannuzel, Stéphane Haik, Elaine Del Bel, Rosana Chehín, Rita Raisman-Vozari, Patrick P. Michel, Nicolas Bizat, Tiago Fleming Outeiro

Publikováno v: Neurobiology of Disease, Vol 151, Iss , Pp 105256- (2021)

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn). Doxycycline, a tetracyclic antibiotic shows neuroprotective effects, initially pro

Externí odkaz: https://doaj.org/article/552ebd9e8d364a10af46c4b3b62a5775

Pharmacological Modulators of Tau Aggregation and Spreading

Autor: Antonio Dominguez-Meijide, Eftychia Vasili, Tiago Fleming Outeiro

Publikováno v: Brain Sciences, Vol 10, Iss 11, p 858 (2020)

Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of tau can propagate from cell to cell and throughout the brain. This process is th

Externí odkaz: https://doaj.org/article/76085397be4b42a49d22868b518b4f23

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

Autor: Simona S. Ghanem, Nour K. Majbour, Nishant N. Vaikath, Mustafa T. Ardah, Daniel Erskine, Nanna Møller Jensen, Muneera Fayyad, Indulekha P. Sudhakaran, Eftychia Vasili, Katerina Melachroinou, Ilham Y. Abdi, Ilaria Poggiolini, Patricia Santos, Anton Dorn, Paolo Carloni, Kostas Vekrellis, Johannes Attems, Ian McKeith, Tiago F. Outeiro, Poul Henning Jensen, Omar M. A. El-Agnaf

Publikováno v: Ghanem, S S, Majbour, N K, Vaikath, N N, Ardah, M T, Erskine, D, Jensen, N M, Fayyad, M, Sudhakaran, I P, Vasili, E, Melachroinou, K, Abdi, I Y, Poggiolini, I, Santos, P, Dorn, A, Carloni, P, Vekrellis, K, Attems, J, McKeith, I, Outeiro, T F, Jensen, P H & El-Agnaf, O M A 2022, ' α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity ', PNAS (Proceedings of the National Academy of Sciences of the United States of America), vol. 119, no. 15, e2109617119 . https://doi.org/10.1073/pnas.2109617119
Proceedings of the National Academy of Sciences of the United States of America 119(15), e2109617119 (2022). doi:10.1073/pnas.2109617119

α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased in Lewy body disease, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). However, the pathogenic relevance of pS129–α-syn remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba55d29b3d2b2ef5284fe1134f6d0e19
https://doi.org/10.1073/pnas.2109617119

Alpha-synuclein levels modulate seeding and aggregation in cultured cells

Autor: Flores-León M, Kanellidi A, Al-Azzani M, Eftychia Vasili, Tiago F. Outeiro, Melki R, Stefanis L, Antonio Dominguez-Meijide

Background Parkinson's disease is a progressive neurodegenerative disorder characterized by the accumulation of misfolded alpha-synuclein in intraneuronal inclusions known as Lewy bodies and Lewy neurites. Multiple studies strongly implicate the leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73aa72e5bd217fa5206a4b71c4b4f4fb
https://doi.org/10.21203/rs.3.rs-666210/v1

The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains

Autor: Samuel Peña-Díaz, Jordi Pujols, Eftychia Vasili, Francisca Pinheiro, Jaime Santos, Zoe Manglano-Artuñedo, Tiago F. Outeiro, Salvador Ventura

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
The journal of biological chemistry 298(5), 101902 (2022). doi:10.1016/j.jbc.2022.101902

Altres ajuts: ICREA (ICREA-Academia 2015 and 2020); Fundació la Marató de TV3 (20144330) Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as the accumulation of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17817c7c08b0a1d4964f9661488d0571
https://doi.org/10.1016/j.jbc.2022.101902