Long-read RNA-seq atlas of novel microglia isoforms elucidates disease-associated genetic regulation of splicing.

Autor: Humphrey J; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brophy E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kosoy R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Zeng B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Coccia E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mattei D; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ravi A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Efthymiou AG; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Navarro E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Biochemistry and Molecular Biology, Faculty of Medicine (Universidad Complutense de Madrid), Madrid, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Madrid, Spain., Muller BZ; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Snijders GJ; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Allan A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Münch A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kitata RB; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Kleopoulos SP; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Argyriou S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Shao Z; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Francoeur N; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tsai CF; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Gritsenko MA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Monroe ME; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Paurus VL; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Weitz KK; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Shi T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Sebra R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Liu T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., de Witte LD; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Goate AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Haroutunian V; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mental Illness Research Education, and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA., Hoffman GE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Fullard JF; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Roussos P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.; Mental Illness Research Education, and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA., Raj T; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Dec 01. Date of Electronic Publication: 2023 Dec 01.

Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs.

Autor: Ramdhani S; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Navarro E; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Udine E; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Efthymiou AG; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Schilder BM; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Parks M; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Goate A; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Raj T; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2020 Feb 03; Vol. 16 (2), pp. e1008549. Date of Electronic Publication: 2020 Feb 03 (Print Publication: 2020).

Induced Pluripotent Stem Cell Models to Enable In Vitro Models for Screening in the Central Nervous System.

Autor: Hunsberger JG; 1 Wake Forest Institute for Regenerative Medicine , Winston-Salem, North Carolina., Efthymiou AG; 2 Uniformed Services University of the Health Sciences , Bethesda, Maryland., Malik N; 3 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH) , Bethesda, Maryland., Behl M; 4 National Toxicology Program, National Institute of Environmental Health Sciences , Research Triangle Park, North Carolina., Mead IL; 1 Wake Forest Institute for Regenerative Medicine , Winston-Salem, North Carolina., Zeng X; 5 Buck Institute for Age Research , Novato, California., Simeonov A; 6 National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) , Rockville, Maryland., Rao M; 7 New York Stem Cell Foundation , New York, New York.

Publikováno v: Stem cells and development [Stem Cells Dev] 2015 Aug 15; Vol. 24 (16), pp. 1852-64. Date of Electronic Publication: 2015 Apr 20.

Compounds with species and cell type specific toxicity identified in a 2000 compound drug screen of neural stem cells and rat mixed cortical neurons.

Autor: Malik N; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, United States. Electronic address: malikn@mail.nih.gov., Efthymiou AG; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, United States., Mather K; National Institute of Neurological Disorders and Stroke, National Institutes of Health, United States., Chester N; National Institute of Neurological Disorders and Stroke, National Institutes of Health, United States., Wang X; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, United States., Nath A; National Institute of Neurological Disorders and Stroke, National Institutes of Health, United States., Rao MS; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, United States; National Institute of Health Center for Regenerative Medicine, National Institutes of Health, United States., Steiner JP; National Institute of Neurological Disorders and Stroke, National Institutes of Health, United States.

Publikováno v: Neurotoxicology [Neurotoxicology] 2014 Dec; Vol. 45, pp. 192-200. Date of Electronic Publication: 2014 Oct 22.

Comparison of the gene expression profiles of human fetal cortical astrocytes with pluripotent stem cell derived neural stem cells identifies human astrocyte markers and signaling pathways and transcription factors active in human astrocytes.

Autor: Malik N; National Institutes of Health, NIAMS, Bethesda, Maryland, United States of America., Wang X; National Institutes of Health, NIAMS, Bethesda, Maryland, United States of America., Shah S; National Institutes of Health, NIAMS, Bethesda, Maryland, United States of America., Efthymiou AG; National Institutes of Health, NIAMS, Bethesda, Maryland, United States of America., Yan B; Hong Kong Baptist University, Department of Biology, Hong Kong., Heman-Ackah S; National Institutes of Health, NIAMS, Bethesda, Maryland, United States of America., Zhan M; The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, Texas, United States of America., Rao M; National Institutes of Health, NIAMS, Bethesda, Maryland, United States of America; National Institutes of Health, NIH Center for Regenerative Medicine, Bethesda, Maryland, United States of America.

Publikováno v: PloS one [PLoS One] 2014 May 21; Vol. 9 (5), pp. e96139. Date of Electronic Publication: 2014 May 21 (Print Publication: 2014).