Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Efthymia Papalexi"'
Autor:
Ross L. Levine, Rong Fan, Franziska Michor, Thomas Radimerski, Masato Murakami, Julie Teruya-Feldstein, Jacqueline Bromberg, Jordan S. Fridman, Vincent Romanet, Jonathan J. Chen, Sachie Marubayashi, Raajit Rampal, Omar Abdel-Wahab, Efthymia Papalexi, Anna Sophia McKenney, Neha Bhagwat, Todd Hricik, Lennart Bastian, Matthew Keller, Markus Riester, Priya Koppikar, Minsuk Kwak, Maria Kleppe
Supplementary Figure 1. Pro-inflammatory cytokines are elevated in MF mice and reversed with JAK inhibitor treatment. Supplementary Figure 2. Principal component analysis of MF cells. Supplementary Figure 3. Single cell analysis of immunophenotypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0739c902c6e921c3e4e3ab17e50ad9dd
https://doi.org/10.1158/2159-8290.22530627
https://doi.org/10.1158/2159-8290.22530627
Autor:
Hans-Hermann Wessels, Alejandro Méndez-Mancilla, Yuhan Hao, Efthymia Papalexi, William M. Mauck, Lu Lu, John A. Morris, Eleni P. Mimitou, Peter Smibert, Neville E. Sanjana, Rahul Satija
Publikováno v:
Nat Methods
Pooled CRISPR screens coupled with single-cell RNA-sequencing have enabled systematic interrogation of gene function and regulatory networks. Here, we introduce Cas13 RNA Perturb-seq (CaRPool-seq), which leverages the RNA-targeting CRISPR-Cas13d syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e962349f11d3f94d4a40ce1a09c64d
https://europepmc.org/articles/PMC10030154/
https://europepmc.org/articles/PMC10030154/
Autor:
Vuong Tran, Efthymia Papalexi, Sarah Schroeder, Grace Kim, Ajay Sapre, Joey Pangallo, Alex Sova, Peter Matulich, Lauren Kenyon, Zeynep Sayar, Ryan Koehler, Daniel Diaz, Archita Gadkari, Kamy Howitz, Maria Nigos, Charles M. Roco, Alexander B. Rosenberg
Single cell RNA sequencing (scRNA-seq) has become a core tool for researchers to understand biology. As scRNA-seq has become more ubiquitous, many applications demand higher scalability and sensitivity. Split-pool combinatorial barcoding makes it pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68b5256d8f4d4ac6ee5d5d0061be7637
https://doi.org/10.1101/2022.08.27.505512
https://doi.org/10.1101/2022.08.27.505512
Autor:
Mayu Hata, Tse Shun Huang, Leif S. Ludwig, Caleb A. Lareau, Wendy Luo, Aviv Regev, James B. Wing, Yusuke Takeshima, Shimon Sakaguchi, Efthymia Papalexi, Peter Smibert, Rahul Satija, Pratiksha I. Thakore, Yuhan Hao, Kristopher L. Nazor, Bertrand Z. Yeung, Kelvin Y. Chen, Vijay G. Sankaran, Andre Luiz Zorzetto-Fernandes, Tatsuya Kibayashi, Eleni P. Mimitou
Publikováno v:
Nature Biotechnology. 39:1246-1258
Recent technological advances have enabled massively parallel chromatin profiling with scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we present ATAC with select antigen profiling by sequencing (ASAP-seq), a t
Autor:
Etienne Coyaud, Rahul Satija, Michelle Chan-Seng-Yue, John E. Dick, Héléna Boutzen, Alex Murison, Shin ichiro Takayanagi, Kerstin B. Kaufmann, Laura García-Prat, Andy G.X. Zeng, Kristele Pan, Olga I. Gan, Estelle M.N. Laurent, Sasan Zandi, Stephanie Z. Xie, Brian Raught, Jessica McLeod, Efthymia Papalexi
Publikováno v:
Nature Immunology
Nature Immunology, 2021, Nature Immunology, 22, pp.723-734. ⟨10.1038/s41590-021-00925-1⟩
Nature Immunology, 2021, Nature Immunology, 22, pp.723-734. ⟨10.1038/s41590-021-00925-1⟩
Continuous supply of immune cells throughout life relies on the delicate balance in the hematopoietic stem cell (HSC) pool between long-term maintenance and meeting the demands of both normal blood production and unexpected stress conditions. Here we
Autor:
Rahul Satija, William M. Mauck, Bernadette Bracken, Andrew Butler, Efthymia Papalexi, Eleni P. Mimitou, Yuhan Hao, Hans-Hermann Wessels, Samantha D. Foster, Bertrand Z. Yeung, Peter Smibert
Publikováno v:
Nature genetics
The expression of inhibitory immune checkpoint molecules, such as programmed death-ligand (PD-L)1, is frequently observed in human cancers and can lead to the suppression of T cell-mediated immune responses. Here, we apply expanded CRISPR-compatible
Autor:
Efthymia Papalexi, Grace Kim, Bryan Hariadi, Sarah Schroeder, Peter Matulich, Vuong Tran, Daniel Diaz, Charles Roco, Alexander Rosenberg
Publikováno v:
Cancer Research. 83:248-248
T cells are able to recognize and eliminate a wide variety of immunologic threats while maintaining self-tolerance. Pathogen recognition and clearance is ensured by a process called V(D)J recombination, during which a T cell obtains a unique set of V
Autor:
Grace Kim, Efthymia Papalexi, Peter Matulich, Ryan Koehler, Sarah Schroeder, Vuong Tran, Charles Roco, Alexander Rosenberg
Publikováno v:
Cancer Research. 83:226-226
In the thirteen years since its inception, single-cell RNA-sequencing (scRNA-seq) has rapidly spread across multiple fields of research, leading to many new discoveries. As technologies have matured, the number of cells that can be processed in a sin
Autor:
Marlon Stoeckius, Shiwei Zheng, Stephanie Hao, Rahul Satija, Lamar M. Fleming, Maddie Jane Lee, Eleni P. Mimitou, Raphael Gottardo, Erica Andersen-Nissen, Jaison Jain, Peter Smibert, Juliana M. McElrath, Andrew Butler, Avi Srivastava, Catherine A. Blish, William M. Mauck, Yuhan Hao, Aaron J. Wilk, Bertrand Z. Yeung, Michael Zager, Efthymia Papalexi, Paul Hoffman, Angela J. Rogers, Charlotte A. Darby, Tim Stuart
Publikováno v:
Cell
Summary The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can define cellular states based on multimodal data. Here, we introduce “weighted-neare
Autor:
Eleni P, Mimitou, Caleb A, Lareau, Kelvin Y, Chen, Andre L, Zorzetto-Fernandes, Yuhan, Hao, Yusuke, Takeshima, Wendy, Luo, Tse-Shun, Huang, Bertrand Z, Yeung, Efthymia, Papalexi, Pratiksha I, Thakore, Tatsuya, Kibayashi, James Badger, Wing, Mayu, Hata, Rahul, Satija, Kristopher L, Nazor, Shimon, Sakaguchi, Leif S, Ludwig, Vijay G, Sankaran, Aviv, Regev, Peter, Smibert
Publikováno v:
Nature biotechnology. 39(10)
Recent technological advances have enabled massively parallel chromatin profiling with scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we present ATAC with select antigen profiling by sequencing (ASAP-seq), a t