Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Efstratios Stratikos"'
Autor:
Galateia Georgaki, Anastasia Mpakali, Myrto Trakada, Athanasios Papakyriakou, Efstratios Stratikos
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionER aminopeptidase 1 (ERAP1) is a polymorphic intracellular aminopeptidase with key roles in antigen presentation and adaptive immune responses. ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displa
Externí odkaz:
https://doaj.org/article/4249348d25da41e481a3ab41c6ab36f9
Autor:
Christina Gkolfinopoulou, Angeliki Bourtsala, Daphne Georgiadou, Anastasia-Georgia Dedemadi, Efstratios Stratikos, Angeliki Chroni
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 5, Pp 100543- (2024)
AapoA-I, the main protein of high-density lipoprotein, plays a key role in the biogenesis and atheroprotective properties of high-density lipoprotein. We showed previously that a naturally occurring apoA-I mutation, L178P, induces major defects in pr
Externí odkaz:
https://doaj.org/article/aec6b27fa1f8471fa3edc75205f9a380
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The endoplasmic-reticulum aminopeptidase ERAP1 processes peptides for antigen presentation. Here, the authors assess ERAP1 conformational states in solution, providing insight into the molecular mechanisms of ERAP1 substrate-length dependent catalyti
Externí odkaz:
https://doaj.org/article/746dd492c81545edb8b75082e4fb3cbb
Autor:
George Mavridis, Anastasia Mpakali, Jerome Zoidakis, Manousos Makridakis, Antonia Vlahou, Eleni Kaloumenou, Angeliki Ziotopoulou, Dimitris Georgiadis, Athanasios Papakyriakou, Efstratios Stratikos
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Processing of N-terminally elongated antigenic peptide precursors by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key step in antigen presentation and the adaptive immune response. Although ERAP1 can efficiently process long peptides
Externí odkaz:
https://doaj.org/article/9bcf23927a2540dbb515f338c76f8451
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/65e11a991e6b4da29fb667ce72edfda0
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses. Although th
Externí odkaz:
https://doaj.org/article/7ea0205a0a92451ab34c0a6de1cb6427
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2339-2348 (2018)
Lipoprotein glomerulopathy (LPG) is a rare renal disease, characterized by lipoprotein thrombi in glomerular capillaries. A series of apoE mutations have been associated with LPG development. We previously showed that three mutants based on apoE3 seq
Externí odkaz:
https://doaj.org/article/90c5607b17a64bd0bfa4d9e6e7aa4710
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/1a1c25b6e0be4085a9103209112bd582
Autor:
Wouter J. Venema, Sanne Hiddingh, Joke H. de Boer, Frans H. J. Claas, Arend Mulder, Anneke I. den Hollander, Efstratios Stratikos, Siranush Sarkizova, Lars T. van der Veken, George M. C. Janssen, Peter A. van Veelen, Jonas J. W. Kuiper
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-positive individuals. Genetic association studies linked ERAP2 with BU, an aminopeptidase which trims peptides before their presentation by HLA class I at the ce
Externí odkaz:
https://doaj.org/article/96774bd91fe94255b5f0907aab6bb0ce
Autor:
Kimberly Seamon, Lesia O. Kurlak, Michelle Warthan, Efstratios Stratikos, Jerome F. Strauss, Hiten D. Mistry, Eun D. Lee
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta. They are involved in processes regulating blood pressure, angioge
Externí odkaz:
https://doaj.org/article/c435f091b8e04e4bbe440f07876f3f4a