Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Efstathios S Gonos"'
Autor:
Vanessa Schoissengeier, Lina Maqboul, Daniela Weber, Tilman Grune, Alexander Bürkle, Maria Moreno-Villaneuva, Claudio Franceschi, Miriam Capri, Jürgen Bernhard, Olivier Toussaint, Florence Debacq-Chainiaux, Birgit Weinberger, Efstathios S. Gonos, Ewa Sikora, Martijn Dollé, Eugène Jansen, P. Eline Slagboom, Antti Hervonnen, Mikko Hurme, Nicolle Breusing, Jan Frank, Andrew C. Bulmer, Karl-Heinz Wagner
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110234- (2024)
Summary: Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite eff
Externí odkaz:
https://doaj.org/article/c552b2d7871143dc8639d53d930fb083
Autor:
Andreas Goutas, Zozo Outskouni, Ioanna Papathanasiou, Aphrodite Georgakopoulou, Georgios E. Karpetas, Efstathios S. Gonos, Varvara Trachana
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102701- (2023)
We and others have reported that senescence onset is accompanied by genomic instability that is evident by several defects, such as aneuploidy or erroneous mitosis features. Here, we report that these defects also appear in young cells upon oxidative
Externí odkaz:
https://doaj.org/article/53d4616103e44ae7a9509108b8c7ef32
Autor:
Patrizia D’Aquila, Robertina Giacconi, Marco Malavolta, Francesco Piacenza, Alexander Bürkle, María Moreno Villanueva, Martijn E. T. Dollé, Eugène Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Antti Hervonen, Mikko Hurme, P. Eline Slagboom, Christiane Schön, Jürgen Bernhardt, Nicolle Breusing, Giuseppe Passarino, Mauro Provinciali, Dina Bellizzi
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The presence of circulating microbiome in blood has been reported in both physiological and pathological conditions, although its origins, identities and function remain to be elucidated. This study aimed to investigate the presence of blood microbio
Externí odkaz:
https://doaj.org/article/4e861e7abb794ca3a368b39764b890dd
Autor:
Marianna Kapetanou, Tobias Nespital, Luke S. Tain, Andre Pahl, Linda Partridge, Efstathios S. Gonos
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Proteostasis collapses during aging resulting, among other things, in the accumulation of damaged and aggregated proteins. The proteasome is the main cellular proteolytic system and plays a fundamental role in the maintenance of protein homeostasis.
Externí odkaz:
https://doaj.org/article/4c518bf1230e4fd586c29f4f97b177ae
Autor:
Ilya Pinchuk, Daniela Weber, Bastian Kochlik, Wolfgang Stuetz, Olivier Toussaint, Florence Debacq-Chainiaux, Martijn E.T. Dollé, Eugène H.J.M. Jansen, Efstathios S. Gonos, Ewa Sikora, Nicolle Breusing, Daniela Gradinaru, Thilo Sindlinger, María Moreno-Villanueva, Alexander Bürkle, Tilman Grune, Dov Lichtenberg
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers
Externí odkaz:
https://doaj.org/article/ff70642965ad4536859d4f5bd6fdafe0
Autor:
Robertina Giacconi, Francesco Piacenza, Valentina Aversano, Michele Zampieri, Alexander Bürkle, María Moreno Villanueva, Martijn E. T. Dollé, Eugène Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Birgit Weinberger, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Wolfgang Stuetz, Pieternella Eline Slagboom, Jürgen Bernhardt, Maria Luisa Fernández-Sánchez, Mauro Provinciali, Marco Malavolta
Publikováno v:
Nutrients; Volume 15; Issue 9; Pages: 2182
An inadequate selenium (Se) status can accelerate the aging process, increasing the vulnerability to age-related diseases. The study aimed to investigate plasma Se and Se species in a large population, including 2200 older adults from the general pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3affc5316d837c192dbbe486e61b32
https://doi.org/10.3390/nu15092182
https://doi.org/10.3390/nu15092182
Autor:
Efstathios S. Gonos, David A. Boothman, Lukas H. Margaritis, Yonglong Zou, Issidora S. Papassideri, Vassilis G. Gorgoulis, Dimitris Kletsas, Marianna H. Antonelou, Magda Lourda, Ioannis P. Trougakos
Purpose: Secretory clusterin (sCLU)/apolipoprotein J is an extracellular chaperone that has been functionally implicated in DNA repair, cell cycle regulation, apoptotic cell death, and tumorigenesis. It exerts a prosurvival function against most ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b6d0d041bb5d63786358a4112eb2bd
https://doi.org/10.1158/1078-0432.c.6516922
https://doi.org/10.1158/1078-0432.c.6516922
Autor:
Efstathios S. Gonos, David A. Boothman, Lukas H. Margaritis, Yonglong Zou, Issidora S. Papassideri, Vassilis G. Gorgoulis, Dimitris Kletsas, Marianna H. Antonelou, Magda Lourda, Ioannis P. Trougakos
Supplementary Data from Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5f576c4bf43d89e21fc830914ca35b
https://doi.org/10.1158/1078-0432.22439461.v1
https://doi.org/10.1158/1078-0432.22439461.v1
Supplementary Figure from Silencing Expression of the Clusterin/Apolipoprotein J Gene in Human Cancer Cells Using Small Interfering RNA Induces Spontaneous Apoptosis, Reduced Growth Ability, and Cell Sensitization to Genotoxic and Oxidative Stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235b8cf22c6bc73d94d28735710efe4e
https://doi.org/10.1158/0008-5472.22363965
https://doi.org/10.1158/0008-5472.22363965
Clusterin/Apolipoprotein J (CLU) is a heterodimeric ubiquitously expressed secreted glycoprotein that is implicated in several physiological processes and is differentially expressed in many severe physiological disturbances, including tumor formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d3bb9ca5f2257b93aaef6936fb26dd
https://doi.org/10.1158/0008-5472.c.6493962
https://doi.org/10.1158/0008-5472.c.6493962