Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Efstathia Thymiakou"'
Autor:
Claire E Kelly, Efstathia Thymiakou, James E Dixon, Shinya Tanaka, Jonathan Godwin, Vasso Episkopou
Publikováno v:
PLoS Biology, Vol 11, Iss 4, p e1001538 (2013)
Little is known about extrinsic signals required for the advancement of motor neuron (MN) axons, which extend over long distances in the periphery to form precise connections with target muscles. Here we present that Rnf165 (Arkadia-like; Arkadia2; A
Externí odkaz:
https://doaj.org/article/d86372d95194484b910d4fc6211e5831
Autor:
Nicholas Redshaw, Carme Camps, Vikas Sharma, Mehdi Motallebipour, Marcela Guzman-Ayala, Spyros Oikonomopoulos, Efstathia Thymiakou, Jiannis Ragoussis, Vasso Episkopou
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55186 (2013)
The Transforming Growth Factor-β (TGF-β) signaling pathway is one of the major pathways essential for normal embryonic development and tissue homeostasis, with anti-tumor but also pro-metastatic properties in cancer. This pathway directly regulates
Externí odkaz:
https://doaj.org/article/0a2eba45ff01472ab54a4c533d4d69f3
Publikováno v:
Metabolism. 139:155371
Hnf4a gene ablation in mouse liver causes hepatic steatosis, perturbs HDL structure and function and affects many pathways and genes related to glucose metabolism. Our aim here was to investigate the role of liver HNF4A in glucose homeostasis.Serum a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a54d95668390d9ed92484f41553f6e0
https://doi.org/10.1016/j.metabol.2022.155371
https://doi.org/10.1016/j.metabol.2022.155371
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1867:159108
Ablation of the gene encoding the nuclear receptor Hepatocyte Nuclear Factor 4a (Hnf4a) in the liver strongly affects HDL concentration, structure and functionality but the role of this receptor in the intestine, the second organ contributing to seru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73821658974ddc4ab1531c35c70e0128
https://doi.org/10.1016/j.bbalip.2021.159108
https://doi.org/10.1016/j.bbalip.2021.159108
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1867:159060
The inverse association between plasma HDL cholesterol (HDL-C) levels and risk for cardiovascular disease (CVD) has been demonstrated by numerous epidemiological studies. However, efforts to reduce CVD risk by pharmaceutically manipulating HDL-C leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f5118a962f52b38911e8827ef66be5
https://doi.org/10.1016/j.bbalip.2021.159060
https://doi.org/10.1016/j.bbalip.2021.159060
Publikováno v:
Metabolism. 110:154307
Background Aberrant concentration, structure and functionality of High Density Lipoprotein (HDL) are associated with many prevalent diseases, including cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). Mice with liver-specific abl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7fab43f535bf782ec376824b817034
https://doi.org/10.1016/j.metabol.2020.154307
https://doi.org/10.1016/j.metabol.2020.154307
Publikováno v:
Biochimica et biophysica acta. Gene regulatory mechanisms. 1860(8)
Lipoprotein lipase (LPL) catalyzes the hydrolysis of triglycerides from triglyceride-rich lipoproteins such as VLDL and chylomicrons in the circulation. Mutations in LPL or its activator apolipoprotein C-II cause hypertriglyceridemia in humans and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1997cd1a1ddf411f51ad00486538559c
https://pubmed.ncbi.nlm.nih.gov/28576574
https://pubmed.ncbi.nlm.nih.gov/28576574
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1839:526-536
ATP binding cassette transporter A1 (ABCA1) plays a key role in the biogenesis of HDL by promoting the efflux of cellular cholesterol and phospholipids to lipid free apoA-I. Mutations in the ABCA1 gene cause Tangier disease which is characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e25ad26b3bc1795954b9a2555137c8
https://doi.org/10.1016/j.bbagrm.2014.04.021
https://doi.org/10.1016/j.bbagrm.2014.04.021
Autor:
Thomas L. Carroll, SiDe Li, Martin J. Walsh, Nikolay Popov, Francesca Aguilo, Ambrosius P. Snijders, Nadine Martin, Gordon Peters, Jesús Gil, Selina Raguz, Gopuraja Dharmalingam, Ana O'Loghlen, Bernd B. Zeisig, Efstathia Thymiakou, Vasso Episkopou, Chi Wai Eric So
Publikováno v:
The EMBO Journal. 32:982-995
The INK4/ARF locus regulates senescence and is frequently altered in cancer. In normal cells, the INK4/ARF locus is found silenced by Polycomb repressive complexes (PRCs). Which are the mechanisms responsible for the recruitment of PRCs to INK4/ARF a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b6b12b4eb11c4c040a1590b6d7d4d5e
https://doi.org/10.1038/emboj.2013.37
https://doi.org/10.1038/emboj.2013.37
Autor:
Jesper Schou, Efstathia Thymiakou, Børge G. Nordestgaard, Anne Tybjærg-Hansen, Peer Grande, Dimitris Kardassis, Gorm B. Jensen, Ruth Frikke-Schmidt
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32:506-515
Objective— ATP binding cassette transporter G1 (ABCG1) facilitates cholesterol efflux from macrophages to mature high-density lipoprotein particles. Whether genetic variation in ABCG1 affects risk of atherosclerosis in humans remains to be determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a4d2b00c69b9d3694511f327889782
https://doi.org/10.1161/atvbaha.111.234872
https://doi.org/10.1161/atvbaha.111.234872