Výsledky vyhledávání - "Efrosyni Themistou"

Functionalization of polymeric nanoparticles with targeting VNAR ligands using vinyl sulfone conjugation

Autor: Adam Leach, Marie Finnegan, Mariana S. Machado, Laura Ferguson, John Steven, Peter Smyth, Andrew Porter, Caroline Barelle, Efrosyni Themistou, Christopher J. Scott

Publikováno v: Leach, A, Finnegan, M, Machado, M S, Ferguson, L, Steven, J, Smyth, P, Porter, A, Barelle, C, Themistou, E & Scott, C J 2023, ' Functionalization of polymeric nanoparticles with targeting VNAR ligands using vinyl sulfone conjugation ', Journal of Materials Chemistry B, vol. 11, no. 19, pp. 4181-4190 . https://doi.org/10.1039/d2tb01985j

Actively targeted drug loaded nanoparticles represent an exciting new form of therapeutics for cancer and other diseases. These formulations are complex and in order to realize their ultimate potential, optimization of their preparation is required.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a35620288f7505084b19f6c10d1a34e
https://pure.qub.ac.uk/en/publications/d0b7c6a1-c5cc-4418-990e-a6ecd289934e

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Wholly Biobased, Highly Stretchable, Hydrophobic, and Self-healing Thermoplastic Elastomer

Autor: Yeyen Nurhamiyah, Marie Finnegan, Amalina Amir, Biqiong Chen, Mohan Edirisinghe, Efrosyni Themistou

Publikováno v: Nurhamiyah, Y, Amir, A, Finnegan, M, Themistou, E, Edirisinghe, M & Chen, B 2021, ' Wholly Biobased, Highly Stretchable, Hydrophobic, and Self-healing Thermoplastic Elastomer ', ACS Applied Materials and Interfaces, vol. 13, no. 5, pp. 6720-6730 . https://doi.org/10.1021/acsami.0c23155

Renewable polymers with excellent stretchability and self-healing ability are interesting for a wide range of applications. A novel type of wholly biobased, self-healing, polyamide-based thermoplastic elastomer was synthesized using a fatty dimer aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0659b0854f87a50989c46551983e9a69
https://doi.org/10.1021/acsami.0c23155

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Evaluation of the In Vitro Cytotoxicity and Modulation of the Inflammatory Response by the Bioresorbable Polymers Poly(D,L-lactide-co-glycolide) and Poly(L-lactide-co-glycolide)

Autor: Louise Carson, Lucy Geddes, James F Burrows, Fraser Buchanan, Efrosyni Themistou

Publikováno v: Geddes, L, Themistou, E, Burrows, J F, Buchanan, F J & Carson, L 2021, ' Evaluation of the In Vitro Cytotoxicity and Modulation of the Inflammatory Response by the Bioresorbable Polymers Poly(D,L-lactide-co-glycolide) and Poly(L-lactide-co-glycolide) ', Acta Biomaterialia, vol. 134, pp. 261-275 . https://doi.org/10.1016/j.actbio.2021.07.049

Bioresorbable polymers composed of poly(D,L-lactide-co-glycolide) (PDLLGA) and poly(L-lactide-co-glycolide) (PLLGA) have become increasingly popular for the preparation of bone substitute constructs. However, there are reports of a delayed inflammato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81820c7f7364d0674c77eae045415524
https://pure.qub.ac.uk/en/publications/48a06711-b56f-4fc5-b402-e7914261a80b

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Novel Biobased Polyamide Thermoplastic Elastomer with Medium Hardness

Autor: Yeyen Nurhamiyah, Biqiong Chen, Efrosyni Themistou, Gavin Irvine

Publikováno v: Nurhamiyah, Y, Irvine, G, Themistou, E & Chen, B 2021, ' Novel Biobased Polyamide Thermoplastic Elastomer with Medium Hardness ', Macromolecular Chemistry and Physics, vol. 222, no. 21, 2100218 . https://doi.org/10.1002/macp.202100218

Thermoplastic elastomers (TPEs) are useful in various engineering and healthcare applications. A new fully biobased polyamide TPE (PA36,9) with medium hardness is reported. The elastomer is synthesized using a fatty dimer amine and azelaic acid, via

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26495c66d0b57576944fda41f1a0935f
https://pure.qub.ac.uk/en/publications/46090231-a6d2-469b-9247-11b3d87ff06e

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Targeting triple-negative breast cancer cells using Dengue virus-mimicking pH-responsive framboidal triblock copolymer vesicles

Autor: Efrosyni Themistou, Pierre Chambon, Oleksandr O. Mykhaylyk, Irene Canton, Charlotte J. Mable, Steven P. Armes, Burcin Ustbas Gul

Publikováno v: Mable, C J, Canton, I, Mykhaylyk, O O, Ustbas Gul, B, Chambon, P, Themistou, E & Armes, S P 2019, ' Targeting triple-negative breast cancer cells using Dengue virus-mimicking pH-responsive framboidal triblock copolymer vesicles ', Chemical Science, vol. 10, no. 18, pp. 4811-4821 . https://doi.org/10.1039/C8SC05589K

It is well-known that the Dengue fever virus undergoes a distinct morphological transition from topologically smooth particles to ‘bumpy’ particle on increasing the temperature from that of the mosquito carrier (28 °C) to that of the human host

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a1878d89b41edfbab0428699d64dbf
https://doi.org/10.1039/c8sc05589k

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A comparison of the increased temperature accelerated degradation of Poly(d,l-lactide-co-glycolide) and Poly(l-lactide-co-glycolide)

Autor: Efrosyni Themistou, Lucy Geddes, Louise Carson, Fraser Buchanan

Publikováno v: Geddes, L, Carson, L, Themistou, E & Buchanan, F 2020, ' A comparison of the increased temperature accelerated degradation of Poly(d,l-lactide-co-glycolide) and Poly(l-lactide-co-glycolide) ', Polymer Testing, vol. 91, 106853 . https://doi.org/10.1016/j.polymertesting.2020.106853

Bioresorbable polymers composed of Poly(lactide), Poly(glycolide) and their related copolymers have become increasingly popular for the preparation of bone substitute constructs. In vitro tests assessing the degradative changes in physicochemical, me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb7f755f581de859a6e9c1ac9a4a8f6
https://pure.qub.ac.uk/en/publications/a-comparison-of-the-increased-temperature-accelerated-degradation-of-polydllactidecoglycolide-and-polyllactidecoglycolide(22ea809f-0fa1-4fd5-ae34-6d3b4a60678f).html

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Star polymers with acid-labile diacetal-based cores synthesized by aqueous RAFT polymerization for intracellular DNA delivery

Autor: Mona Semsarilar, Peter Smyth, Aidan P. McCann, Michael C. Johnston, William J. McDaid, Christopher J. Scott, Thomas J. Gibson, Efrosyni Themistou

Publikováno v: Polymer Chemistry
Polymer Chemistry, Royal Society of Chemistry-RSC, 2020, 11 (2), pp.344-357. ⟨10.1039/c9py00573k⟩
Gibson, T J, Smyth, P, Semsarilar, M, McCann, A P, McDaid, W J, Johnston, M C, Scott, C J & Themistou, E 2019, ' Star polymers with acid-labile diacetal-based cores synthesized by aqueous RAFT polymerization for intracellular DNA delivery ', Polymer Chemistry, vol. 11, no. 2, pp. 344-357 . https://doi.org/10.1039/c9py00573k

International audience; The application of DNA-based therapeutics holds much potential, but it is limited by the ability to successfully deliver and transfect target cells. Here, acid-labile diacetal-based star polymers were synthesized by a facile '

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a97d70f0860651163a344587889053
https://hal.archives-ouvertes.fr/hal-03005850

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Development of amphiphilic block copolymers as silica optical fiber overlayers for BSA protein detection

Autor: Afroditi Petropoulou, Stergios Pispas, Efrosyni Themistou, Christos Riziotis, Thomas J. Gibson

Publikováno v: Petropoulou, A, Gibson, T J, Themistou, E, Pispas, S & Riziotis, C 2018, ' Development of amphiphilic block copolymers as silica optical fiber overlayers for BSA protein detection ', Materials Chemistry and Physics, vol. 216, pp. 421-428 . https://doi.org/10.1016/j.matchemphys.2018.06.027

Novel amphiphilic block copolymers having both hydrophobic poly(methyl methacrylate) (PMMA) and hydrophilic poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) blocks have been designed and synthesized for efficient protein detection in photonic-base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0a0dadcb5b4961a6a6923d54e6554d
https://doi.org/10.1016/j.matchemphys.2018.06.027

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Low temperature gamma sterilization of a bioresorbable polymer, PLGA

Autor: Eoin Cunningham, Efrosyni Themistou, Fraser Buchanan, Lisa Davison

Publikováno v: Davison, L, Themistou, E, Buchanan, F & Cunningham, E 2017, ' Low Temperature Gamma Sterilisation of a Bioresorbable Polymer, PLGA ', Radiation Physics and Chemistry, pp. 1-9 . https://doi.org/10.1016/j.radphyschem.2017.09.009

Medical devices destined for insertion into the body must be sterilised before implantation to prevent infection or other complications. Emerging biomaterials, for example bioresorbable polymers, can experience changes in their properties due to stan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f05411825c60349fa65e69da476b68
https://doi.org/10.1016/j.radphyschem.2017.09.009

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Electrosprayed cysteine-functionalized degradable amphiphilic block copolymer microparticles for low pH-triggered drug delivery

Autor: Marie Finnegan, Efrosyni Themistou, Gerard Mallon, Adam Leach

Publikováno v: Finnegan, M, Mallon, G, Leach, A & Themistou, E 2019, ' Electrosprayed cysteine-functionalized degradable amphiphilic block copolymer microparticles for low pH-triggered drug delivery ', Polymer Chemistry, vol. 10, pp. 5814-5820 . https://doi.org/10.1039/c9py01221d

Thiol-functionalized polymeric microparticles have attracted interest as mucoadhesive drug delivery formulations. However, new approaches are needed to optimize the preparation of these systems for patient use. Here, N-hydroxysuccinimide (NHS)-functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00c5ebbc066ce6e1da17e97b1fd314e
https://pure.qub.ac.uk/en/publications/electrosprayed-cysteinefunctionalized-degradable-amphiphilic-block-copolymer-microparticles-for-low-phtriggered-drug-delivery(48573380-85f0-4270-a430-f82a0e4db65f).html

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