Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Efrat Shavit‐Stein"'
Autor:
Valery Golderman, Shany Guly Gofrit, Yanina Ivashko-Pachima, Illana Gozes, Joab Chapman, Efrat Shavit-Stein
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33329- (2024)
The cell surface protease-activated receptor 1 (PAR1) is overexpressed in glioblastoma multiforme (GBM). We studied the function and structure of intracellular microtubule (MT) and PAR1 in a tubulin-mediated process. We found that exposure to thrombi
Externí odkaz:
https://doaj.org/article/c7d00b6de06646ca9df866eb20e72615
Autor:
Amir Dori, Michael Arad, Yishay Wasserstrum, Arthur Pollak, Vera Nikitin, Merav Ben‐David, Jana Shamash, Ayelet Hashachar Nahum, Efrat Shavit‐Stein, Liran Domachevsky, Rafael Kuperstein, Dan Dominissini, Natalia Shelestovich, Menachem Sadeh, Elon Pras, Lior Greenbaum
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 4, Pp 553-567 (2023)
Abstract Objective Amyloidosis due to the transthyretin Ser77Tyr mutation (ATTRS77Y) is a rare autosomal‐dominant disorder, characterized by carpal‐tunnel syndrome, poly‐ and autonomic‐neuropathy, and cardiomyopathy. However, related symptoms
Externí odkaz:
https://doaj.org/article/68c41e30acf44131b822b27749f5984e
Autor:
Valery Golderman, Marina Ben-Shimon, Nicola Maggio, Amir Dori, Shany Guly Gofrit, Shani Berkowitz, Lamis Qassim, Avital Artan-Furman, Talya Zeimer, Joab Chapman, Efrat Shavit-Stein
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract Background Inflammation and coagulation are linked and pathogenic in neuroinflammatory diseases. Protease-activated receptor 1 (PAR1) can be activated both by thrombin, inducing increased inflammation, and activated protein C (aPC), inducing
Externí odkaz:
https://doaj.org/article/4c1a170703a24d97a16202238f8b022f
Autor:
Dor Freidin, Meirav Har-Even, Vardit Rubovitch, Kathleen E. Murray, Nicola Maggio, Efrat Shavit-Stein, Lee Keidan, Bruce A. Citron, Chaim G. Pick
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1481 (2023)
Traumatic brain injury (TBI) is considered the most common neurological disorder among people under the age of 50. In modern combat zones, a combination of TBI and organophosphates (OP) can cause both fatal and long-term effects on the brain. We util
Externí odkaz:
https://doaj.org/article/1ac25c05aa2142b6bc123f6b7814e692
Autor:
Alexandra Gerasimov, Valery Golderman, Shany Guly Gofrit, Shay Anat Aharoni, Daniela Noa Zohar, Ze’ev Itsekson-Hayosh, Tsviya Fay-Karmon, Sharon Hassin-Baer, Joab Chapman, Nicola Maggio, Efrat Shavit-Stein
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 10, Pp 2086-2092 (2021)
Inflammation and coagulation are tightly interconnected in the pathophysiology of neuronal diseases. Thrombin, a pro-coagulant serine protease is associated with neurodegeneration and its indirect inhibitor, activated protein C (aPC), is considered n
Externí odkaz:
https://doaj.org/article/f8010ee07e7645e4ba682a2c255e20a0
Autor:
Efrat Shavit-Stein, Shani Berkowitz, Tal Davidy, Uri Fennig, Shani Guly Gofrit, Amir Dori, Nicola Maggio
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
BackgroundStatus epilepticus (SE) leads to memory impairment following a seizure, attributed to long-term potentiation (LTP) reduction. Thrombin, a coagulation factor that activates protease-activated receptor 1 (PAR1) is involved in cognitive impair
Externí odkaz:
https://doaj.org/article/11df81da0d7c42498a14415184dca4a3
Autor:
Rivka Goldis, Batia Kaplan, Olga (Lesya) Kukuy, Michael Arad, Hila Magen, Efrat Shavit-Stein, Amir Dori, Avi Livneh
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4655 (2023)
Amyloidosis refers to a clinically heterogeneous group of disorders characterized by the extracellular deposition of amyloid proteins in various tissues of the body. To date, 42 different amyloid proteins that originate from normal precursor proteins
Externí odkaz:
https://doaj.org/article/bdfa4ce0253e4ce2b17f7299e364cc98
Autor:
Valery Golderman, Zehavit Goldberg, Shany Guly Gofrit, Amir Dori, Nicola Maggio, Joab Chapman, Ifat Sher, Ygal Rotenstreich, Efrat Shavit-Stein
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2021 (2023)
Diabetic encephalopathy (DE) is an inflammation-associated diabetes mellitus (DM) complication. Inflammation and coagulation are linked and are both potentially modulated by inhibiting the thrombin cellular protease-activated receptor 1 (PAR1). Our a
Externí odkaz:
https://doaj.org/article/8ceb1322924842e0a54e9f48e3ae45d4
Autor:
Shani Berkowitz, Shany Guly Gofrit, Shay Anat Aharoni, Valery Golderman, Lamis Qassim, Zehavit Goldberg, Amir Dori, Nicola Maggio, Joab Chapman, Efrat Shavit-Stein
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10472 (2022)
Background. Due to the interactions between neuroinflammation and coagulation, the neural effects of lipopolysaccharide (LPS)-induced inflammation (1 mg/kg, intraperitoneal (IP), n = 20) and treatment with the anti-thrombotic enoxaparin (1 mg/kg, IP,
Externí odkaz:
https://doaj.org/article/d083dc606b7c4cd6b8b779866275f6f0
Autor:
Shany G Gofrit, Efrat Shavit-Stein
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 12, Pp 2043-2053 (2019)
The neuro-glial interface extends far beyond mechanical support alone and includes interactions throu-gh coagulation cascade proteins. Here, we systematically review the evidence indicating that synaptic and node of Ranvier glia cell components modul
Externí odkaz:
https://doaj.org/article/dd4d4f2b50f740328dcda822d8677eba