Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Efrat Ozeri-Galai"'
Autor:
Verena Passerini, Efrat Ozeri-Galai, Mirjam S. de Pagter, Neysan Donnelly, Sarah Schmalbrock, Wigard P. Kloosterman, Batsheva Kerem, Zuzana Storchová
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
One of the hallmarks of cancer cells is aneuploidy, however the molecular effects are poorly understood. Here the authors show that trisomic and tetrasomic cells display increased genomic instability and reduced levels of the helicase MCM2-7.
Externí odkaz:
https://doaj.org/article/e73b828e409d4bfbb86d27e03daef072
Autor:
Yifat S. Oren, Ofra Avizur-Barchad, Efrat Ozeri-Galai, Renana Elgrabli, Meital R. Schirelman, Tehilla Blinder, Chava D. Stampfer, Merav Ordan, Onofrio Laselva, Malena Cohen-Cymberknoh, Eitan Kerem, Christine E Bear, Batsheva Kerem
Publikováno v:
Journal of Cystic Fibrosis. 21:630-636
Antisense oligonucleotide- based drugs for splicing modulation were recently approved for various genetic diseases with unmet need. Here we aimed to generate skipping over exon 23 of the CFTR transcript, to eliminate the W1282X nonsense mutation and
Autor:
Efrat Ozeri-Galai, Lital Friedman, null Ofra-Barchad-Avitzur, Matthew R Markovetz, William Boone, Kaitlyn R Rouillard, Chava D Stampfer, Yifat S Oren, David B Hill, Batsheva Kerem, Gili Hart
The last years have shown enormous advancement in the therapeutic potential of RNA-related treatments, specifically for antisense oligonucleotide (ASO)-based drugs, leading to increased numbers of ASO regulatory approvals. In this study we focus on S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0633060cb2f46556fe1d306a533247ba
https://doi.org/10.1101/2023.01.09.23284328
https://doi.org/10.1101/2023.01.09.23284328
Autor:
Ofra Barchad-Avitzur, Yifat S. Oren, Liran Carmel, Venkateshwar Mutyam, Steve D. Wilton, Eric J. Sorscher, Isabelle Sermet-Gaudelus, A. Hatton, Efrat Ozeri-Galai, Steven M. Rowe, Yao Li, Batsheva Kerem, Joel Reiter, A. Golec, Eitan Kerem, Chen Leibson, Michal Irony-Tur Sinai, Jeong S. Hong
Publikováno v:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Background Antisense oligonucleotide (ASO)-based drugs for splicing modulation were recently approved for various genetic diseases with unmet need. Here we aimed to develop an ASO-based splicing modulation therapy for Cystic Fibrosis (CF) patients ca
Autor:
M. Schirelman, O. Avizur-Barchad, T. Fogel, C. Bear, O. Laselva, R. Elgrabli, Batsheva Kerem, Efrat Ozeri-Galai, M. Ordan, Yifat S. Oren, Eitan Kerem
Publikováno v:
Journal of Cystic Fibrosis. 20:S286-S287
Autor:
Jeong S. Hong, Steve D. Wilton, Batsheva Kerem, Steven M. Rowe, Efrat Ozeri-Galai, Joel Reiter, Eitan Kerem, Yuanyuan Li, M. Irony-Tur Sinai, A. Hatton, Yifat S. Oren, Eric J. Sorscher, Isabelle Sermet-Gaudelus, Venkateshwar Mutyam, A. Golec, O. Barchad-Avitzur
Antisense oligonucleotide (ASO)-based drugs for splicing modulation were recently been approved for various genetic diseases with unmet need. Here we aimed to develop an ASO-based splicing modulation therapy for Cystic Fibrosis (CF) patients carrying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8e15a38ea3b35ae2503e7b00fb62da4
https://doi.org/10.1101/2021.02.14.431123
https://doi.org/10.1101/2021.02.14.431123
Autor:
A. Golec, Yifat S. Oren, O. Avizur-Barchad, Eitan Kerem, Efrat Ozeri-Galai, M. Wilschanski, A. Hatton, Isabelle Sermet-Gaudelus, N. Stanleigh, M. Irony-Tur Sinai, Batsheva Kerem
Publikováno v:
Journal of Cystic Fibrosis. 20:S49
Publikováno v:
Cellular and Molecular Life Sciences. 71:4495-4506
Common fragile sites (CFSs) are regions within the normal chromosomal structure that were characterized as hotspots for genomic instability in cancer almost 30 years ago. In recent years, many efforts have been made to understand the basis of CFS fra
Publikováno v:
Oncogene. 27:2109-2117
Common fragile sites are specific genomic loci that form constrictions and gaps on metaphase chromosomes under conditions that slow, but do not arrest, DNA replication. These sites have been shown to have a role in various chromosomal rearrangements
Publikováno v:
Trends in genetics : TIG. 28(6)
Common fragile sites (CFSs) were characterized almost 30 years ago as sites undergoing genomic instability in cancer. Recently, in vitro studies have found that oncogene-induced replication stress leads to CFS instability. In vivo, CFSs were found to