Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Efrat Lev-Lehman"'
Autor:
Michael F Wangler, Claudia Gonzaga-Jauregui, Tomasz Gambin, Samantha Penney, Timothy Moss, Atul Chopra, Frank J Probst, Fan Xia, Yaping Yang, Steven Werlin, Ieva Eglite, Liene Kornejeva, Carlos A Bacino, Dustin Baldridge, Jeff Neul, Efrat Lev Lehman, Austin Larson, Joke Beuten, Donna M Muzny, Shalini Jhangiani, Baylor-Hopkins Center for Mendelian Genomics, Richard A Gibbs, James R Lupski, Arthur Beaudet
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004258 (2014)
Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) is a rare disorder of enteric smooth muscle function affecting the intestine and bladder. Patients with this severe phenotype are dependent on total parenteral nutrition and urinary ca
Externí odkaz:
https://doaj.org/article/5e906b4e11814a4b99a07d1ad5eeb99e
Autor:
Fan Xia, Ieva Eglite, Michael F. Wangler, Frank J. Probst, Claudia Gonzaga-Jauregui, James R. Lupski, Austin Larson, Carlos A. Bacino, Timothy J. Moss, Dustin Baldridge, Arthur L. Beaudet, Efrat Lev Lehman, Jeffrey L. Neul, Yaping Yang, Joke Beuten, Richard A. Gibbs, Shalini N. Jhangiani, Tomasz Gambin, Samantha Penney, Donna M. Muzny, Steven L. Werlin, Liene Kornejeva, Atul R. Chopra
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004258 (2014)
PLoS Genetics
PLoS Genetics
Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) is a rare disorder of enteric smooth muscle function affecting the intestine and bladder. Patients with this severe phenotype are dependent on total parenteral nutrition and urinary ca
Publikováno v:
Journal of Human Genetics. 46:0362-0366
Most neuronal nicotinic acetylcholine receptors are heteropentamers, composed of alpha and beta subunits. Mice lacking the alpha3 subunit and mice lacking both the beta2 and beta4 subunits, but not mice lacking the beta2 or beta4 subunits alone, have
Autor:
Hermona Soreq, Ilana Ariel, Eran Meshorer, Ron S. Broide, Efrat Lev-Lehman, Shlomo Seidman, Tamah Evron
Publikováno v:
Journal of Molecular Neuroscience. 14:093-106
Environmental, congenital, and acquired immunological insults perturbing neuromuscular junction (NMJ) activity may induce a variety of debilitating neuromuscular pathologies. However, the molecular elements linking NMJ dysfunction to long-term myopat
Autor:
Efrat Lev-Lehman, David M. Lonard, Carolyn L. Smith, Ming-Jer Tsai, Bert W. O'Malley, Zafar Nawaz, Sophia Y. Tsai
Publikováno v:
Molecular and Cellular Biology. 19:1182-1189
In this study, we found that the E6-associated protein (E6-AP/UBE3A) directly interacts with and coactivates the transcriptional activity of the human progesterone receptor (PR) in a hormone-dependent manner. E6-AP also coactivates the hormone-depend
Autor:
Alon Friedman, Efrat Lev-Lehman, Rachel Beeri, Hermona Soreq, Moshe Shani, Sivan Henis, Rina Timberg, Christian R. Andres
Publikováno v:
Proceedings of the National Academy of Sciences. 94:8173-8178
To explore the possibility that overproduction of neuronal acetylcholinesterase (AChE) confers changes in both cholinergic and morphogenic intercellular interactions, we studied developmental responses to neuronal AChE overexpression in motoneurons a
Publikováno v:
Blood. 89:3644-3653
Acetylcholinesterase (AChE) is expressed in murine megakaryocytes (MK), where its antisense inhibition suppresses differentiation, yet was never detected in human MK. Here, we report that AChE is produced in normal human bone marrow MK and in cell li
Publikováno v:
Cellular and Molecular Neurobiology. 14:459-473
1. To investigate the possibility that cholinesterase inhibitors may cause adverse hematopoietic effects, we employed antisense oligodeoxynucleotides selectively inhibiting butyrylcholinesterase gene expression (AS-BCHE). Complementary sense (S) olig
Autor:
Hermona Soreq, Efrat Lev-Lehman, Ahmed El-Tamer, Israel Hanin, Avraham Yaron, Dalia Ginzberg, Mirta Grifman
Publikováno v:
Brain Research. 661:75-82
To study the mechanisms underlying cholinotoxic brain damage, we examined ethylcholine aziridinium (AF64A) effects on cholinesterase genes. In vitro, AF64A hardly affected cholinesterase activities yet inhibited transcription of the G,C-rich AChE DNA
Autor:
Y Lipidot-Lifson, Shlomo Seidman, Judy Lieman-Hurwitz, Dalia Ginzberg, Catherine A. Prody, Hermona Soreq, Efrat Lev-Lehman, Lewis F. Neville, Averell Gnatt, Revital Ben-Aziz
Publikováno v:
Proceedings of the National Academy of Sciences. 87:9688-9692
To study the primary structure of human acetylcholinesterase (AcChoEase; EC 3.1.1.7) and its gene expression and amplification, cDNA libraries from human tissues expressing oocyte-translatable AcChoEase mRNA were constructed and screened with labeled