Validation of the prognostic value of CD3 and CD8 cell densities analogous to the Immunoscore® by stage and location of colorectal cancer: an independent patient cohort study

Autor: Elizabeth Alwers, Jakob N Kather, Matthias Kloor, Alexander Brobeil, Katrin E Tagscherer, Wilfried Roth, Amelie Echle, Efrat L Amitay, Jenny Chang‐Claude, Hermann Brenner, Michael Hoffmeister

Publikováno v: The Journal of Pathology: Clinical Research, Vol 9, Iss 2, Pp 129-136 (2023)

Abstract In addition to the traditional staging system in colorectal cancer (CRC), the Immunoscore® has been proposed to characterize the level of immune infiltration in tumor tissue and as a potential prognostic marker. The aim of this study was to

Externí odkaz: https://doaj.org/article/4c9e90af24084aecaf17e369708cd7af

Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

Autor: Syed H. Zaidi, Tabitha A. Harrison, Amanda I. Phipps, Robert Steinfelder, Quang M. Trinh, Conghui Qu, Barbara L. Banbury, Peter Georgeson, Catherine S. Grasso, Marios Giannakis, Jeremy B. Adams, Elizabeth Alwers, Efrat L. Amitay, Richard T. Barfield, Sonja I. Berndt, Ivan Borozan, Hermann Brenner, Stefanie Brezina, Daniel D. Buchanan, Yin Cao, Andrew T. Chan, Jenny Chang-Claude, Charles M. Connolly, David A. Drew, Alton Brad Farris, Jane C. Figueiredo, Amy J. French, Charles S. Fuchs, Levi A. Garraway, Steve Gruber, Mark A. Guinter, Stanley R. Hamilton, Sophia Harlid, Lawrence E. Heisler, Akihisa Hidaka, John L. Hopper, Wen-Yi Huang, Jeroen R. Huyghe, Mark A. Jenkins, Paul M. Krzyzanowski, Mathieu Lemire, Yi Lin, Xuemei Luo, Elaine R. Mardis, John D. McPherson, Jessica K. Miller, Victor Moreno, Xinmeng Jasmine Mu, Reiko Nishihara, Nickolas Papadopoulos, Danielle Pasternack, Michael J. Quist, Adilya Rafikova, Emma E. G. Reid, Eve Shinbrot, Brian H. Shirts, Lincoln D. Stein, Cherie D. Teney, Lee Timms, Caroline Y. Um, Bethany Van Guelpen, Megan Van Tassel, Xiaolong Wang, David A. Wheeler, Christina K. Yung, Li Hsu, Shuji Ogino, Andrea Gsur, Polly A. Newcomb, Steven Gallinger, Michael Hoffmeister, Peter T. Campbell, Stephen N. Thibodeau, Wei Sun, Thomas J. Hudson, Ulrike Peters

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutation

Externí odkaz: https://doaj.org/article/a09dab8e99d844a6a6258b23214b612c

Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases

Autor: Tomotaka Ugai, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Naohiko Akimoto, Sonja Berndt, Hermann Brenner, Daniel D. Buchanan, Jenny Chang-Claude, Kenji Fujiyoshi, Steven J. Gallinger, Marc J. Gunter, Akihisa Hidaka, Michael Hoffmeister, Li Hsu, Mark A. Jenkins, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Rish K. Pai, Lori C. Sakoda, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Michael O. Woods, Syed H. Zaidi, John D. Potter, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Amanda I. Phipps, Ulrike Peters, Shuji Ogino

Publikováno v: American Journal of Gastroenterology. 118:712-726

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::554ec7f9678fdf5f495786b31a9d685e
https://doi.org/10.14309/ajg.0000000000002171

The Bidirectional Association of Chronic Kidney Disease, Type 2 Diabetes, Atherosclerotic Cardiovascular Disease, and Heart Failure: The Cardio–Renal–Metabolic Syndrome

Autor: Gregory A. Nichols, Efrat L. Amitay, Satabdi Chatterjee, Dominik Steubl

Publikováno v: Metabolic Syndrome and Related Disorders.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b540ee4c287f00b0cdbbfb531d0cf84f
https://doi.org/10.1089/met.2023.0006

Data from Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies

Autor: Ulrike Peters, Peter T. Campbell, Daniel D. Buchanan, Li Hsu, Wei Sun, Michael Hoffmeister, Stephen N. Thibodeau, Bethany Van Guelpen, Michael O. Woods, Xiaoliang Wang, Caroline Y. Um, Robert S. Steinfelder, Martha L. Slattery, John D. Potter, Patrick S. Parfrey, Mireia Obón-Santacana, Shuji Ogino, Reiko Nishihara, Polly A. Newcomb, Victor Moreno, Yi Lin, Mark A. Jenkins, Heather Hampel, Sophia Harlid, Mark A. Guinter, Marc J. Gunter, Steven Gallinger, Andrew T. Chan, Ivan Borozan, Sonja I. Berndt, Efrat L. Amitay, Amanda E. Toland, Syed H. Zaidi, Jane C. Figueiredo, Amanda I. Phipps, Mingyang Song, Marios Giannakis, Richard Barfield, Lori C. Sakoda, Yin Cao, Tabitha A. Harrison, Akihisa Hidaka

Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all epidemiologic studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a5a91cc8f58c76b6b865e9f73fe0ed
https://doi.org/10.1158/0008-5472.c.6512209