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pro vyhledávání: '"Efrat Deleon"'
Zinc–desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa
Autor:
Eyal Banin, Michal Lederman, Eduard Berenshtein, Itay Chowers, Mordechai Chevion, Ruslana Alper-Pinus, Ruth Yaul, Efrat Deleon, Alexey Obolensky, Baruch Bulvik
Publikováno v:
Free Radical Biology and Medicine. 51:1482-1491
Iron-associated oxidative injury plays a role in retinal degeneration such as age-related macular degeneration and retinitis pigmentosa. The metallo-complex zinc-desferrioxamine (Zn/DFO) may ameliorate such injury by chelation of labile iron in combi
Publikováno v:
Investigative ophthalmologyvisual science. 50(3)
PURPOSE. Altered iron metabolism was implicated in retinal and macular degeneration. This study was designed to further elucidate iron homeostasis during the course of retinal degeneration in mice. METHODS. Retinal mRNA and protein expression of tran