Výsledky vyhledávání - "Efrat Halbfinger"

Akademický článek

BL-7010 demonstrates specific binding to gliadin and reduces gluten-associated pathology in a chronic mouse model of gliadin sensitivity.

Autor: Justin L McCarville, Yotam Nisemblat, Heather J Galipeau, Jennifer Jury, Rinat Tabakman, Ad Cohen, Esmira Naftali, Bela Neiman, Efrat Halbfinger, Joseph A Murray, Arivarasu N Anbazhagan, Pradeep K Dudeja, Alexander Varvak, Jean-Christophe Leroux, Elena F Verdu

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e109972 (2014)

Celiac disease (CD) is an autoimmune disorder in individuals that carry DQ2 or DQ8 MHC class II haplotypes, triggered by the ingestion of gluten. There is no current treatment other than a gluten-free diet (GFD). We have previously shown that the BL-

Externí odkaz: https://doaj.org/article/7087f82fe61d4343ab2aa2478ca871df

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BL-7010 Demonstrates Specific Binding to Gliadin and Reduces Gluten-Associated Pathology in a Chronic Mouse Model of Gliadin Sensitivity

Autor: Pradeep K. Dudeja, Elena F. Verdu, Bela Neiman, Heather J. Galipeau, Joseph A. Murray, Alexander Varvak, Jean-Christophe Leroux, Esmira Naftali, Ad Cohen, Arivarasu Natarajan Anbazhagan, Efrat Halbfinger, Rinat Tabakman, Justin L. McCarville, Yotam Nisemblat, Jennifer Jury

Publikováno v: PLoS ONE, 9 (11)
PLoS ONE, Vol 9, Iss 11, p e109972 (2014)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b23c84cbe73cbab8d6141d0f8d159d
https://hdl.handle.net/20.500.11850/281618

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Novel modified adenosine 5′-triphosphate analogues pharmacologically characterized in human embryonic kidney 293 cells highly expressing rat brain P2Y1 receptor

Autor: Gregor Zündorf, Bilha Fischer, Efrat Halbfinger, Rainer Schäfer, Georg Reiser, Christian Vöhringer

Publikováno v: Biochemical Pharmacology. 61:1259-1269

Rat brain P2Y 1 (rP2Y 1 ) receptor-transfected human embryonic kidney cells (HEK 293) were recently shown to have enhanced reactivity to both ATP and ADP (Vohringer C, Schafer R, Reiser G. Biochem Pharmacol 2000;59:791–800). Here, we demonstrated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc5c10e5a00398cbfca3e1ae035227ca
https://doi.org/10.1016/s0006-2952(01)00593-7

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Molecular Recognition of Modified Adenine Nucleotides by the P2Y1-Receptor. 1. A Synthetic, Biochemical, and NMR Approach

Autor: Bilha Fischer, José L. Boyer, Georg Reiser, Dan Thomas Major, Kendall T. Harden, Marco Ritzmann, Efrat Halbfinger, Joachim J. Ubl

Publikováno v: Journal of Medicinal Chemistry. 42:5325-5337

The remarkably high potencies of 2-thioether-adenine nucleotides regarding the activation of the P2Y(1)-receptor (P2Y(1)-R) in turkey erythrocyte membranes represent some of the largest substitution-promoted increases in potencies over that of a natu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8fa1bd7d756d61cd8e28754075dfb4
https://doi.org/10.1021/jm990156d

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Molecular Recognition of Modified Adenine Nucleotides by the P2Y1-Receptor. 2. A Computational Approach

Autor: Bilha Fischer, Efrat Halbfinger, Dan Thomas Major

Publikováno v: Journal of Medicinal Chemistry. 42:5338-5347

The molecular recognition of C2- or C8-substituted ATP derivatives by the P2Y(1)-receptor (P2Y(1)-R) is analyzed using ab initio quantum mechanical calculations. Parameters that may determine ligand specificity toward P2Y(1)-R were examined on reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b27833a4dc14ed0a62af3fe6cb62858
https://doi.org/10.1021/jm9901576

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Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity

Autor: Avi Faier, Dana Yarden, Efrat Halbfinger, Yael Gabinet, Deborah E. Shalev, Oded Ovadia, Shmuel Hess, Zhimin Xiang, Tair Lapidot, Avi Swed, Yaniv Linde, Chaim Gilon, Carrie Haskell-Luevano, Amnon Hoffman, Eli Safrai, Federico P. Portillo, Ilan Winkler

Publikováno v: Journal of medicinal chemistry. 51(4)

The tetrapeptide sequence His-Phe-Arg-Trp, derived from melanocyte-stimulating hormone (alphaMSH) and its analogs, causes a decrease in food intake and elevates energy utilization upon binding to the melanocortin-4 receptor (MC4R). To utilize this se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f3838dbc50ba65b50cd863d6379339
https://pubmed.ncbi.nlm.nih.gov/18220330

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Inhibitors of NTPDase: Key Players in the Metabolism of Extracellular Purines

Autor: Fernand-Pierre Gendron, Bilha Fischer, Adrien R. Beaudoin, Efrat Halbfinger

Publikováno v: Purine and Pyrimidine Metabolism in Man X ISBN: 0306465159

This study described the potential of a new class of ATP analogues as NTPDase inhibitors. From previous studies, 8-BuS-ATP appears to be a specific and efficient NTPDase inhibitor.10–11 This novel inhibitor is a new tool to regulate NTPDase activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f9e7505c8ac7dc9c2089b4829b61c16
https://doi.org/10.1007/0-306-46843-3_24

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Photoaffinity labeling on magnetic microspheres (PALMm) methodology for topographic mapping: preparation of PALMm reagents and demonstration of biochemical relevance

Autor: Karine Gorochesky, Adrien R. Beaudoin, Larisa Sheihet, Bilha Fischer, Shlomo Margel, Sébastien A. Lévesque, Efrat Halbfinger

Publikováno v: Organicbiomolecular chemistry. 1(16)

Photoaffinity labeling (PAL) is a technique widely used for identifying the binding-site within proteins. Although the classic method is both versatile and powerful, it suffers significant disadvantages, such as the need to radiolabel the PAL ligand,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85aed820a12c17a54176fac6bbe6a43
https://pubmed.ncbi.nlm.nih.gov/12968331

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Novel inhibitors of nucleoside triphosphate diphosphohydrolases: chemical synthesis and biochemical and pharmacological characterizations

Autor: Pedro D'Orléans-Juste, Bilha Fischer, Fernand-Pierre Gendron, Adrien R. Beaudoin, Martine Duval, Efrat Halbfinger

Publikováno v: Journal of medicinal chemistry. 43(11)

To elucidate the physiological role played by nucleoside triphosphate diphosphohydrolase (NTPDase; EC 3.6.1.5), adenine nucleotide analogues, modified on the purine ring, have been synthesized and tested as potential inhibitors. Resistance of ATP ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269794ee245bd5edabed57273b953a0c
https://pubmed.ncbi.nlm.nih.gov/10841802

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