Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Efrain Cepeda-Prado"'
Autor:
Jessica Giacomoni, Mette Habekost, Efrain Cepeda-Prado, Bengt Mattsson, Daniella Rylander Ottosson, Malin Parmar, Janko Kajtez
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102041- (2023)
Summary: Tissue clearing is commonly used for whole-brain imaging but seldom used for brain slices. Here, we present a simple protocol to slice, immunostain, and clear sections of adult rat brains for subsequent high-resolution confocal imaging. The
Externí odkaz:
https://doaj.org/article/c0dfa2b7e4f14de895dbe51742d920da
Autor:
Tal Nuriel, Sergio L. Angulo, Usman Khan, Archana Ashok, Qiuying Chen, Helen Y. Figueroa, Sheina Emrani, Li Liu, Mathieu Herman, Geoffrey Barrett, Valerie Savage, Luna Buitrago, Efrain Cepeda-Prado, Christine Fung, Eliana Goldberg, Steven S. Gross, S. Abid Hussaini, Herman Moreno, Scott A. Small, Karen E. Duff
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The APOE4 allele is the leading risk factor for late-onset Alzheimer’s disease, but how it might contribute to the disease is not clear. Here the authors show that a mouse expressing the human APOE4 allele displays hyperactivity in the entorhinal c
Externí odkaz:
https://doaj.org/article/91098ce8e7d943429a161e6bc0ddcf3e
Autor:
Isaac Canals, Andrea Comella-Bolla, Efrain Cepeda-Prado, Natalia Avaliani, James A Crowe, Leal Oburoglu, Andreas Bruzelius, Naomi King, María A Pajares, Dolores Pérez-Sala, Andreas Heuer, Daniella Rylander Ottosson, Jordi Soriano, Henrik Ahlenius
31p.-7 fig. 1 graph. abst.
Frontotemporal dementia is the second most prevalent type of early-onset dementia and up to 40% of cases are familial forms. One of the genes mutated in patients is CHMP2B, which encodes a protein found in a complex im
Frontotemporal dementia is the second most prevalent type of early-onset dementia and up to 40% of cases are familial forms. One of the genes mutated in patients is CHMP2B, which encodes a protein found in a complex im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c4a4db415b4276375c5db268ebe720
http://hdl.handle.net/10261/309652
http://hdl.handle.net/10261/309652
Autor:
Nika Gvazava, Sabine Konings, Efrain Cepeda-Prado, Valeriia Skoryk, Chimezie H. Umeano, Jiao Dong, Iran A.N. Silva, Daniella Rylander Ottosson, Nicholas D. Leigh, Darcy E. Wagner, Oxana Klementieva
Label-free chemical and structural imaging of complex living tissue and biological systems is the holy grail of biomedical research and clinical diagnostics. The current analysis techniques are time-consuming and/or require extensive sample preparati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c7add6ff45a8c5fd521364cce75f273
https://doi.org/10.1101/2023.01.05.522847
https://doi.org/10.1101/2023.01.05.522847
Autor:
Elke Edelmann, Efrain Cepeda-Prado, Swantje Beythien, Gloria D. Quiceno, Volkmar Lessmann, Babak Khodaie
Publikováno v:
Cerebral Cortex. 32:1682-1703
High-frequency stimulation induced long-term potentiation (LTP), or low frequency stimulation induced LTD are considered as cellular models of memory formation. Interestingly, spike timing-dependent plasticity (STDP) can induce equally robust timing-
Autor:
Herman Moreno, Mark G. Stewart, William W. Lytton, Samuel A. Neymotin, Li Liu, Sergio Angulo, Efrain Cepeda-Prado, Rena Orman, Scott A. Small, Luna Buitrago, D. Stefanov, Karen Duff
Publikováno v:
Neurobiology of Disease, Vol 108, Iss, Pp 261-276 (2017)
The entorhinal cortex (EC) is affected early in Alzheimer's disease, an illness defined by a co-occurrence of tau and amyloid-related pathologies. How the co-occurrence of these pathologies in the EC affects the hippocampal circuit remains unknown. H
Autor:
Luna Buitrago, Sheina Emrani, Karen Duff, Steven S. Gross, Mathieu Herman, Eliana Goldberg, Valerie Savage, Herman Moreno, Usman A. Khan, Scott A. Small, Christine Fung, Helen Y. Figueroa, Efrain Cepeda-Prado, Tal Nuriel, Archana Ashok, Geoffrey Barrett, Sergio Angulo, S. Abid Hussaini, Li Liu, Qiuying Chen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications
The ε4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason APOE4 is associated with increased AD risk remains a source of debate. Neuronal hyperactivity is an early phe
Autor:
Petra Lichtenecker, Efrain Cepeda-Prado, Martin Franck, Elke Edelmann, Volkmar Leßmann, Tanja Brigadski
Publikováno v:
Neuron. 86:1041-1054
SummaryTiming-dependent LTP (t-LTP) is a physiologically relevant type of synaptic plasticity that results from repeated sequential firing of action potentials (APs) in pre- and postsynaptic neurons. t-LTP can be observed in vivo and is proposed to b
Coexistence of Multiple Types of Synaptic Plasticity in Individual Hippocampal CA1 Pyramidal Neurons
Publikováno v:
Frontiers in Synaptic Neuroscience
Understanding learning and memory mechanisms is an important goal in neuroscience. To gain insights into the underlying cellular mechanisms for memory formation, synaptic plasticity processes are studied with various techniques in different brain reg
Autor:
Susanna Popp, Jorge Rodríguez, Diana Dow-Edwards, Liliana B. Menalled, Scott A Small, Dimitre Stefanov, Efrain Cepeda-Prado, Herman Moreno, Usman A. Khan
Publikováno v:
The Journal of Neuroscience. 32:6456-6467
A hallmark feature of Huntington's disease pathology is the atrophy of brain regions including, but not limited to, the striatum. Though MRI studies have identified structural CNS changes in several Huntington's disease (HD) mouse models, the functio