Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Efraín Polo-Cuadrado"'
Unexpected discovery: 'A new 3,3′-bipyrazolo[3,4-b]pyridine scaffold and its comprehensive analysis'
Autor:
Efraín Polo-Cuadrado, Karoll Ferrer, Jesús Sánchez-Márquez, Andrés Charris-Molina, Yeray A. Rodríguez-Núñez, Luis Espinoza-Catalán, Margarita Gutiérrez
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32573- (2024)
In this study, a novel 3,3′-bipyrazolo [3,4-b]pyridine-type structure was synthesized from 5-acetylamino-3-methyl-1-phenylpyrazole using the Vilsmeier-Haack reaction as a key step. The spectroscopic properties and structural elucidation of the comp
Externí odkaz:
https://doaj.org/article/577ecfbb28914c37be3ce32cfdbb44bc
Autor:
Efraín Polo-Cuadrado, Karen Acosta-Quiroga, Cristian Rojas-Peña, Yeray A. Rodriguez-Nuñez, Yorley Duarte, Iván Brito, Jonathan Cisterna, Margarita Gutiérrez
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 2, Pp 103540- (2022)
In an attempt to rationalize the search for new potential anti-inflammatory compounds on the COX-2 enzyme, we carried out an in silico protocol that successfully combines the prediction of physicochemical and pharmacokinetic properties, molecular doc
Externí odkaz:
https://doaj.org/article/952489a82d76454395357642e8a66aa5
Autor:
Cristian Valdés, Oscar Valdés, Daniel Bustos, Diana Abril, Gustavo Cabrera-Barjas, Alfredo Pereira, Jorge Villaseñor, Efraín Polo-Cuadrado, Gustavo Carreño, Esteban F. Durán-Lara, Adolfo Marican
Publikováno v:
Polymers, Vol 13, Iss 22, p 3993 (2021)
Pesticides are used worldwide to increase crop yields in agriculture. However, their toxicity and accumulation capacity can make them toxic to the environment, animals and humans. In the case of workers chronically exposed to these substances, they m
Externí odkaz:
https://doaj.org/article/ca13f1b9dc1c4e8ea78e1f2825c79468
Autor:
Efraín Polo-Cuadrado, Karoll Ferrer, Edison Osorio, Iván Brito, Jonathan Cisterna, Luis Espinoza, Joel B. Alderete, Margarita Gutiérrez
Publikováno v:
RSC Advances. 13:5197-5207
A single crystal of a piperonal chalcone derivative was obtained, fully characterized, and crystallized by a slow evaporation technique.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df264af6d9c622fdd292d9096095f2bd
https://doi.org/10.1039/d2ra08101f
https://doi.org/10.1039/d2ra08101f
Autor:
Efraín Polo-Cuadrado, Cristian Rojas-Peña, Karen Acosta-Quiroga, Lorena Camargo-Ayala, Iván Brito, Jonathan Cisterna, Félix Moncada, Jorge Trilleras, Yeray A. Rodríguez-Núñez, Margarita Gutierrez
Publikováno v:
RSC advances. 12(51)
Pyrazole-fused phenanthroline compounds were obtained through several synthetic routes. NMR, HRMS, and IR techniques were used to characterize and confirm the chemical structures. Crystal structures were obtained from compounds 3a, 5b, 5j, 5k, and 5n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d1d3bf80d4752ac5440316534dc7c5
https://pubmed.ncbi.nlm.nih.gov/36425206
https://pubmed.ncbi.nlm.nih.gov/36425206
Autor:
Karen Acosta-Quiroga, Cristian Rojas-Peña, Efraín Polo-Cuadrado, Iván Brito, Yeray A. Rodriguez-Nuñez, Yorley Duarte, Jonathan Cisterna, Margarita Gutiérrez
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 2, Pp 103540-(2022)
In an attempt to rationalize the search for new potential anti-inflammatory compounds on the COX-2 enzyme, we carried out an in silico protocol that successfully combines the prediction of physicochemical and pharmacokinetic properties, molecular doc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1521019af43792713e6350ec68671933
http://www.sciencedirect.com/science/article/pii/S1878535221005554
http://www.sciencedirect.com/science/article/pii/S1878535221005554
Autor:
Lorena Camargo-Ayala, Efraín Polo-Cuadrado, Edison Osorio, Jorge Soto-Delgado, Yorley Duarte, Luis Prent-Peñaloza, Margarita Gutiérrez
Publikováno v:
Journal of Molecular Structure. 1264:133307
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f27134e71efc4acceb3b29b80307c83a
https://doi.org/10.1016/j.molstruc.2022.133307
https://doi.org/10.1016/j.molstruc.2022.133307
Autor:
Efraín Polo-Cuadrado, Karoll Ferrer, Oscar Forero-Doria, Alejandro Morales-Bayuelo, Iván Brito, Jonathan Cisterna, Luis Espinoza, Jesús Sánchez-Márquez, Margarita Gutiérrez
Publikováno v:
Journal of Molecular Structure. 1260:132826
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98a70e0c91ab3c800c86f5fea1983f44
https://doi.org/10.1016/j.molstruc.2022.132826
https://doi.org/10.1016/j.molstruc.2022.132826
Autor:
Margarita Gutiérrez, Karen Acosta-Quiroga, Luz Stella Nerio, Efraín Polo-Cuadrado, Cristian Rojas-Peña
Publikováno v:
RSC advances. 11(36)
In recent years, spiro compounds have attracted significant interest in medicinal chemistry due to their numerous biological activities attributed primarily to their versatility and structural similarity to important pharmacophore centers. Currently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6084d7d3ac5078211c0a936b2e04cd3
https://pubmed.ncbi.nlm.nih.gov/35480788
https://pubmed.ncbi.nlm.nih.gov/35480788
Autor:
Iván Brito, Margarita Gutiérrez, Efraín Polo-Cuadrado, Edison Osorio, Luis Prent-Peñaloza, Lorena Camargo-Ayala, Wendy González, Jonathan Cisterna
Publikováno v:
Journal of Molecular Structure. 1248:131544
In this study, we reported for the first time the crystalline and molecular structure of the compound N-(naphthalen-1-yl) -2- (piperidin-1-yl) acetamide. The synthesis of the compound was carried out by amidation using a coupling reagent (N, N'-diiso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf8bac6f7b5a4b472a6824dfd8aff54b
https://doi.org/10.1016/j.molstruc.2021.131544
https://doi.org/10.1016/j.molstruc.2021.131544