Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Effie Apostolou"'
Autor:
Vianne R. Gao, Rui Yang, Arnav Das, Renhe Luo, Hanzhi Luo, Dylan R. McNally, Ioannis Karagiannidis, Martin A. Rivas, Zhong-Min Wang, Darko Barisic, Alireza Karbalayghareh, Wilfred Wong, Yingqian A. Zhan, Christopher R. Chin, William S. Noble, Jeff A. Bilmes, Effie Apostolou, Michael G. Kharas, Wendy Béguelin, Aaron D. Viny, Danwei Huangfu, Alexander Y. Rudensky, Ari M. Melnick, Christina S. Leslie
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Identifying cell-type-specific 3D chromatin interactions between regulatory elements can help decipher gene regulation and interpret disease-associated non-coding variants. However, achieving this resolution with current 3D genomics technolo
Externí odkaz:
https://doaj.org/article/9058f5eecd4a4599ae65bc3feace0303
Autor:
Samuel Joseph Kaplan, Wilfred Wong, Jielin Yan, Julian Pulecio, Hyein S. Cho, Qianzi Li, Jiahui Zhao, Jayanti Leslie-Iyer, Jonathan Kazakov, Dylan Murphy, Renhe Luo, Kushal K. Dey, Effie Apostolou, Christina S. Leslie, Danwei Huangfu
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114640- (2024)
Summary: Functional enhancer annotation is critical for understanding tissue-specific transcriptional regulation and prioritizing disease-associated non-coding variants. However, unbiased enhancer discovery in disease-relevant contexts remains challe
Externí odkaz:
https://doaj.org/article/18884ea54402465ca393dbb1bcd2118f
Autor:
Priscillia Lhoumaud, Gunjan Sethia, Franco Izzo, Theodore Sakellaropoulos, Valentina Snetkova, Simon Vidal, Sana Badri, Macintosh Cornwell, Dafne Campigli Di Giammartino, Kyu-Tae Kim, Effie Apostolou, Matthias Stadtfeld, Dan Avi Landau, Jane Skok
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Activation of regulatory elements is thought to be inversely correlated with DNA methylation levels. However, it is difficult to determine whether DNA methylation is compatible with chromatin accessibility or transcription factor (TF) bindin
Externí odkaz:
https://doaj.org/article/05d80c0806d0468d85038fa65c963014
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Proper lymphopoiesis and immune responses depend on the spatiotemporal control of multiple processes, including gene expression, DNA recombination and cell fate decisions. High-order 3D chromatin organization is increasingly appreciated as an importa
Externí odkaz:
https://doaj.org/article/7ef15880b6c34ca8b7ceffac26a2b27c
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3597-3604.e3 (2020)
Summary: Cultured pluripotent cells accumulate detrimental chromatin alterations, including DNA methylation changes at imprinted genes known as loss of imprinting (LOI). Although the occurrence of LOI is considered a stochastic phenomenon, here we do
Externí odkaz:
https://doaj.org/article/ebf7ded8496b47599c3fd739255493c8
Autor:
Ting Zhou, Tae Wan Kim, Chi Nok Chong, Lei Tan, Sadaf Amin, Zohreh Sadat Badieyan, Suranjit Mukherjee, Zaniar Ghazizadeh, Hui Zeng, Min Guo, Miguel Crespo, Tuo Zhang, Reyn Kenyon, Christopher L. Robinson, Effie Apostolou, Hui Wang, Jenny Zhaoying Xiang, Todd Evans, Lorenz Studer, Shuibing Chen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and t
Externí odkaz:
https://doaj.org/article/73d56573bdd642718c8b15d27f8152fb
Autor:
Bhishma Amlani, Yiyuan Liu, Taotao Chen, Ly-Sha Ee, Peter Lopez, Adriana Heguy, Effie Apostolou, Sang Yong Kim, Matthias Stadtfeld
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 876-884 (2018)
The ability of induced pluripotent stem cells (iPSCs) to differentiate into all adult cell types makes them attractive for research and regenerative medicine; however, it remains unknown when and how this capacity is established. We characterized the
Externí odkaz:
https://doaj.org/article/a4cfb01762b445a2beda7344a568f3a4
Autor:
Yiyuan Liu, Bobbie Pelham-Webb, Dafne Campigli Di Giammartino, Jiexi Li, Daleum Kim, Katsuhiro Kita, Nestor Saiz, Vidur Garg, Ashley Doane, Paraskevi Giannakakou, Anna-Katerina Hadjantonakis, Olivier Elemento, Effie Apostolou
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1283-1293 (2017)
During mitosis, transcription is halted and many chromatin features are lost, posing a challenge for the continuity of cell identity, particularly in fast cycling stem cells, which constantly balance self-renewal with differentiation. Here we show th
Externí odkaz:
https://doaj.org/article/a34a1a992bc64ae499cff97a102695a3
Autor:
Marti Borkent, Brian D. Bennett, Brad Lackford, Ori Bar-Nur, Justin Brumbaugh, Li Wang, Ying Du, David C. Fargo, Effie Apostolou, Sihem Cheloufi, Nimet Maherali, Stephen J. Elledge, Guang Hu, Konrad Hochedlinger
Publikováno v:
Stem Cell Reports, Vol 6, Iss 5, Pp 704-716 (2016)
The generation of induced pluripotent stem cells (iPSCs) from differentiated cells following forced expression of OCT4, KLF4, SOX2, and C-MYC (OKSM) is slow and inefficient, suggesting that transcription factors have to overcome somatic barriers that
Externí odkaz:
https://doaj.org/article/b11125427b77433898ca63a05cc6349a
Autor:
Partha Pratim Das, David A. Hendrix, Effie Apostolou, Alice H. Buchner, Matthew C. Canver, Semir Beyaz, Damir Ljuboja, Rachael Kuintzle, Woojin Kim, Rahul Karnik, Zhen Shao, Huafeng Xie, Jian Xu, Alejandro De Los Angeles, Yingying Zhang, Junho Choe, Don Leong Jia Jun, Xiaohua Shen, Richard I. Gregory, George Q. Daley, Alexander Meissner, Manolis Kellis, Konrad Hochedlinger, Jonghwan Kim, Stuart H. Orkin
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1456-1470 (2015)
Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from
Externí odkaz:
https://doaj.org/article/1df7a215a1ef40d9b878abbe95055043