Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Effie, Tozzo"'
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/f66848966f31402490e0db0d4c7d5d6e
Autor:
Daniel Treacy, Isabelle Le Mercier, Sunny Sun, Dongmei Xiao, Laura Isacco, Emilie Artru, Scott Steelman, Alex Wolf, Morag Stewart, Effie Tozzo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/5f0863480d284cb490088f463e8fcd2b
Autor:
Dongmei Xiao, Sunny Sun, Morag Stewart, Isabelle Le Mercier, J Bradley, Emilie Artru, Laura Isacco, Alex Wolf, Effie Tozzo, Scott Steelman, Daniel J. Treacy
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundT cell responses are tightly regulated and require a constant balance of signals during the different stages of their activation, expansion, and differentiation. As a result of chronic antigen exposure, T cells become exhausted in solid tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a9b3105b675db1e637262c262b2d92
https://doaj.org/article/5f0863480d284cb490088f463e8fcd2b
https://doaj.org/article/5f0863480d284cb490088f463e8fcd2b
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126642 (2015)
Hyperinsulinemic-euglycemic clamps are considered the "gold standard" for assessing whole body insulin sensitivity. When used in combination with tracer dilution techniques and physiological insulin concentrations, insulin sensitization can be dissec
Externí odkaz:
https://doaj.org/article/b9cb24e16ca74f84ba18993fe907540a
Autor:
Ross Fredenburg, Matthew M. Goddeeris, Jennifer K Truong, Effie Tozzo, Dominique Stickens, Robert W. Shine, Eric L. Bell, Peter Dwyer, Lyndsay Olson
Publikováno v:
Mitochondrion. 46:51-58
Duchenne muscular dystrophy (DMD) is a recessive, fatal X-linked disease that is characterized by progressive skeletal muscle wasting due to the absence of dystrophin, which is an a essential protein that bridges the inner cytoskeleton and extra-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c48a8f8c9081cb3f6797bc8e3393b4c
https://doi.org/10.1016/j.mito.2018.02.006
https://doi.org/10.1016/j.mito.2018.02.006
Autor:
Bharat Lagu, Eric L. Bell, Effie Tozzo, Nirbhay Kumar Tiwari, Andrew Basinski, Arthur F. Kluge, Matthew M. Goddeeris, Ramesh S. Senaiar, Narasimha Rao Krishnamurthy, Ross Fredenburg, Sunil Kumar Panigrahi, Michael A. Patane, Mahaboobi Jaleel, Taisuke Takahashi, Peter Dwyer
Publikováno v:
ACS Medicinal Chemistry Letters. 9:935-940
The X-ray structure of the previously reported PPARδ modulator 1 bound to the ligand binding domain (LBD) revealed that the amide moiety in 1 exists in the thermodynamically disfavored cis-amide orientation. Isosteric replacement of the cis-amide wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0663921ac4e0f062d40544f2aece30db
https://doi.org/10.1021/acsmedchemlett.8b00287
https://doi.org/10.1021/acsmedchemlett.8b00287
Autor:
Ross Fredenburg, Matthew M. Goddeeris, Shekar Chellur, Ramesh S. Senaiar, Bharat Lagu, Mahaboobi Jaleel, Michael A. Patane, Nirbhay Kumar Tiwari, D. Ravi Krishna Babu, Arthur F. Kluge, Taisuke Takahashi, Effie Tozzo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:533-536
Compound 1 regulates significantly fewer genes than the PPARδ modulator, GW501516. Both compounds are efficacious in a thermal injury model of muscle regeneration. The restricted gene profile of 1 relative to GW501516 suggests that 1 may be pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80494cd1dc0ce8e0d6d599fa2dca230c
https://doi.org/10.1016/j.bmcl.2017.11.006
https://doi.org/10.1016/j.bmcl.2017.11.006
Autor:
Michael Malamas, Morag Stewart, Anthony Monti, Youli Xia, Sarah Lin, Mauricio Cortes, Effie Tozzo, Sunny Sun, Orna Lynch, Sriram Krishnamoorthy, Scott Steelman
Publikováno v:
Blood. 138:2022-2022
Induction of fetal hemoglobin (HbF) to treat sickle cell disease (SCD) and beta-thalassemia has been validated as a clinical strategy to ameliorate these diseases. However, despite advances in cell and gene therapy to treat SCD, current approaches st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59e666b73e1df2e25216c8d489d6f9d
https://doi.org/10.1182/blood-2021-152728
https://doi.org/10.1182/blood-2021-152728
Autor:
Mahaboobi Jaleel, Matthew M. Goddeeris, Ramesh S. Senaiar, Peter Dwyer, Eric L. Bell, Sunil Kumar Panigrahi, Ross Fredenburg, Bharat Lagu, Narasimha Rao Krishnamurthy, Andrew Basinski, Michael A. Patane, Nirbhay Kumar Tiwari, Taisuke Takahashi, Effie Tozzo, Arthur F. Kluge
[Image: see text] The X-ray structure of the previously reported PPARδ modulator 1 bound to the ligand binding domain (LBD) revealed that the amide moiety in 1 exists in the thermodynamically disfavored cis-amide orientation. Isosteric replacement o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6579f783424d3bdf0cdce8fc284c2809
https://europepmc.org/articles/PMC6580794/
https://europepmc.org/articles/PMC6580794/
Autor:
Effie Tozzo, Eric S. Muise, Yejun Tan, Sandra C. Souza, Karni Schlessinger, John R. Thompson, Liangsu Wang, Franklin Liu, Kevin Liu, Wenyu Li
Publikováno v:
Obesity. 23:1818-1829
Objective Identify a gene expression signature in white adipose tissue (WAT) that reports on WAT browning and is associated with a healthy phenotype. Methods RNA from several different adipose depots across three species were analyzed by whole transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd620e8fe9ecc10d1f32a9804cf20a2e
https://doi.org/10.1002/oby.21153
https://doi.org/10.1002/oby.21153