Predicting biomolecular function from 3D dynamics : sequence-sensitive coarse-grained elastic network model coupled to machine learning

Autor: Mailhot, Olivier

La dynamique structurelle des biomolécules est intimement liée à leur fonction, mais très coûteuse à étudier expériementalement. Pour cette raison, de nombreuses méthodologies computationnelles ont été développées afin de simuler la dyna

Externí odkaz: http://hdl.handle.net/1866/28572
https://orcid.org/0000-0002-7533-4561

Suboptimal Global Transcriptional Response Increases the Harmful Effects of Loss-of-Function Mutations

Autor: Dorottya Kalapis, Patrick Kemmeren, Karola Almási, Juan F. Poyatos, Csaba Pál, Richard A. Notebaart, Balázs Papp, Zoltán Bódi, Bálint Kintses, Zoltán Farkas, Djordje Bajić, Andreea Daraba, Frank C. P. Holstege, Károly Kovács

Publikováno v: Molecular Biology and Evolution
Molecular Biology and Evolution, 38(3), 1137-1150
Molecular Biology and Evolution 38 (2020) 3

The fitness impact of loss-of-function mutations is generally assumed to reflect the loss of specific molecular functions associated with the perturbed gene. Here, we propose that rewiring of the transcriptome upon deleterious gene inactivation is fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be60b9965a4d0a2aa0bd2baf5af36ea
http://europepmc.org/articles/PMC7947755

Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling

Autor: Panagiotis Katsonis, Jonathan Gallion, Michel Bouvier, Amanda Koire, Olivier Lichtarge, Anne-Marie Schoenegge

Publikováno v: Human Mutation

Computational prediction yields efficient and scalable initial assessments of how variants of unknown significance may affect human health. However, when discrepancies between these predictions and direct experimental measurements of functional impac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506cb336b0e9986f93f087beeab46de0
https://doi.org/10.1002/humu.23193

Overestimation of the adaptive substitution rate in fluctuating populations

Autor: Maeva Mollion, Benoit Nabholz, Nicolas Galtier, Thomas Bataillon, Marjolaine Rousselle

Publikováno v: Rousselle, M, Mollion, M, Nabholz, B, Bataillon, T & Galtier, N 2018, ' Overestimation of the adaptive substitution rate in fluctuating populations ', Biology Letters, vol. 14, no. 5, 20180055 . https://doi.org/10.1098/rsbl.2018.0055
Biology Letters
Biology Letters, Royal Society, The, 2018, 14 (5), ⟨10.1098/rsbl.2018.0055⟩

Estimating the proportion of adaptive substitutions (α) is of primary importance to uncover the determinants of adaptation in comparative genomic studies. Several methods have been proposed to estimateαfrom patterns polymorphism and divergence in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9078748ad93180a6376554116b07de3e
https://pure.au.dk/portal/da/publications/overestimation-of-the-adaptive-substitution-rate-in-fluctuating-populations(fb964688-0a2f-4861-85c2-14f2b02dcf30).html

Evaluating the effect of mutations and ligand binding on transthyretin homotetramer dynamics

Autor: Gustavo Parisi, Giuseppe Zanotti, Sebastian Fernandez-Alberti, Tadeo E. Saldaño

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181019 (2017)

Native transthyretin (TTR) homotetramer dissociation is the first step of the fibrils formation process in amyloid disease. A large number of specific point mutations that destabilize TTR quaternary structure have shown pro-amyloidogenic effects. Bes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3dabe6078c221993b74a9b9ffdbe68
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181019