Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Eeva-Christine Brockmann"'
Autor:
Nayanendu Saha, Sang Gyu Lee, Eeva-Christine Brockmann, M. Jason de la Cruz, Yehuda Goldgur, Rachelle P. Mendoza, Elisa de Stanchina, Tanzy M. Love, Josh Marvald, Yan Xu, Kai Xu, Juha P. Himanen, Urpo Lamminmäki, Darren Veach, Dimitar B. Nikolov
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117605- (2024)
ADAM17 sheds EGFR/erbB ligands and triggers oncogenic pathways that lead to the progression of solid tumors. We targeted the ADAM17 disintegrin and cysteine rich domain region (D+C) to generate a panel of single-chain antibody fragments (scFvs) that
Externí odkaz:
https://doaj.org/article/84264756775b4efcb4e2b8cf8b67bcb8
Autor:
Ida Alanko, Rebecca Sandberg, Eeva‐Christine Brockmann, Carla J. C. deHaas, Jos A. G. vanStrijp, Urpo Lamminmäki, Outi M. H. Salo‐Ahen
Publikováno v:
MicrobiologyOpen, Vol 12, Iss 4, Pp n/a-n/a (2023)
Abstract Staphylococcus aureus produces numerous virulence factors that manipulate the immune system, helping the bacteria avoid phagocytosis. In this study, we are investigating three immune evasion molecules called the staphylococcal superantigen
Externí odkaz:
https://doaj.org/article/6fdee959588f4c3087aa0871c5a809ad
Autor:
Eero Hietanen, Lav Tripathi, Eeva-Christine Brockmann, Pirjo Merilahti, Urpo Lamminmäki, Petri Susi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Human parechoviruses (PeVs) are common viruses that are associated with a variety of diseases from mild gastrointestinal and respiratory symptoms to severe central nervous system infections. Until now there has not been antibodies for visual
Externí odkaz:
https://doaj.org/article/6ce76c23cef349b9a3ce4462053803bb
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100362- (2020)
Externí odkaz:
https://doaj.org/article/1f5c3460f80f463981930358ade1275b
Autor:
Tuomas Huovinen, Eeva-Christine Brockmann, Sultana Akter, Susan Perez-Gamarra, Jani Ylä-Pelto, Yuan Liu, Urpo Lamminmäki
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31817 (2012)
Primer extension mutagenesis is a popular tool to create libraries for in vitro evolution experiments. Here we describe a further improvement of the method described by T.A. Kunkel using uracil-containing single-stranded DNA as the template for the p
Externí odkaz:
https://doaj.org/article/64e23d5e584145e49fec1df0ac7a6f01
Autor:
Kamran Khan, Tuomas Huovinen, Eeva-Christine Brockmann, Urpo Lamminmäki, Heidi Hannula, Mikko Pyykkö
Publikováno v:
New Biotechnology. 60:173-182
Loop length variation in the complementary determining regions (CDRs) 1 and 2 encoded in germline variable antibody genes provides structural diversity in naïve antibody libraries. In synthetic single framework libraries the parental CDR-1 and CDR-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75b2a25a1568b04136ebd2ac2acf581
https://doi.org/10.1016/j.nbt.2020.09.002
https://doi.org/10.1016/j.nbt.2020.09.002
Publikováno v:
Calcified Tissue International
Osteocalcin is a bone-specific protein which contains three glutamic acid residues (Glu) that undergo post-translational gamma-carboxylation. Uncarboxylated osteocalcin (ucOC) may participate in the regulation of glucose metabolism, thus measurement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b103d5e28d4332d340b1f080d53f28
http://europepmc.org/articles/PMC7593320
http://europepmc.org/articles/PMC7593320
Publikováno v:
Bone Reports, Vol 13, Iss, Pp 100362-(2020)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d8a87abc0e63587cf14e9717d70d07
https://doi.org/10.1016/j.bonr.2020.100362
https://doi.org/10.1016/j.bonr.2020.100362
Autor:
Markus Vehniäinen, Markku Syrjänpää, Tuomas Huovinen, Eeva Christine Brockmann, Urpo Lamminmäki, Qi Wang, Hanna Sanmark, Alex Azhayev
Publikováno v:
Protein Engineering, Design and Selection. 26(10):683-693
In directed evolution experiments, a single randomization scheme of an antibody gene does not provide optimal diversity for recognition of all sizes of antigens. In this study, we have expanded the recognition potential of our universal library, term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2433a59849b3c76858f11309a74342e2
http://juuli.fi/Record/0040044913
http://juuli.fi/Record/0040044913
Autor:
Janita Lövgren, Nina Sirkka, Matti Jauhiainen, Priyanka Negi, Eeva-Christine Brockmann, Jari Metso, Paivi Malmi, Kim Pettersson, Tuomas Huovinen, Urpo Lamminmäki
Publikováno v:
Clinical biochemistry. 49(6)
Objective In epidemiological studies plasma high density lipoprotein cholesterol (HDL-C) levels are found to correlate inversely with atherosclerotic cardiovascular events. HDL consists of different subpopulations and they vary in their anti-atheroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e13d4f03627729fe9397763a3e99be
https://pubmed.ncbi.nlm.nih.gov/26656638
https://pubmed.ncbi.nlm.nih.gov/26656638