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of 2
pro vyhledávání: '"Eeva Vieras"'
Autor:
Janne J. Mäkinen, Yeonoh Shin, Eeva Vieras, Pasi Virta, Mikko Metsä-Ketelä, Katsuhiko S. Murakami, Georgiy A. Belogurov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
RNA and DNA polymerases need to discriminate efficiently against closely related nucleotide triphosphate substrates. Here, the authors show that a conserved Arg residue is the major determinant of selectivity against deoxyribonucleoside substrates by
Externí odkaz:
https://doaj.org/article/1a267789452f415e8760bfc2fe901636
Autor:
Janne J, Mäkinen, Yeonoh, Shin, Eeva, Vieras, Pasi, Virta, Mikko, Metsä-Ketelä, Katsuhiko S, Murakami, Georgiy A, Belogurov
Publikováno v:
Nature Communications
RNA polymerases (RNAPs) synthesize RNA from NTPs, whereas DNA polymerases synthesize DNA from 2′dNTPs. DNA polymerases select against NTPs by using steric gates to exclude the 2′OH, but RNAPs have to employ alternative selection strategies. In si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70293d3644c6e8d17d3d9460be2961a2
https://pubmed.ncbi.nlm.nih.gov/33542236
https://pubmed.ncbi.nlm.nih.gov/33542236