Výsledky vyhledávání - "Eeva, Sommer"

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Autor: Eeva Sommer, Dario R. Alessi, Barry R. Davies, Darren Cross, Sylvie Guichard, Hannah Dry

Publikováno v: Biochemical Journal. 452:499-508

The majority of human cancers harbour mutations promoting activation of the Akt protein kinase, and Akt inhibitors are being evaluated in clinical trials. An important question concerns the understanding of the innate mechanisms that confer resistanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6f9cdd02b445a137e64a9f423bfc8a
https://doi.org/10.1042/bj20130342

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The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth

Autor: Ruzica Bago, Claire Crafter, Pau Castel, Eeva Sommer, José Baselga, Natalia Shpiro, Dario R. Alessi, Fiona P. Bailey, Patrick A. Eyers, Darren Cross

Publikováno v: The EMBO Journal
EMBO JOURNAL

We explore mechanisms that enable cancer cells to tolerate PI3K or Akt inhibitors. Prolonged treatment of breast cancer cells with PI3K or Akt inhibitors leads to increased expression and activation of a kinase termed SGK3 that is related to Akt. Und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3392caacfd1f3426baa077a6be0197a6
https://pubmed.ncbi.nlm.nih.gov/27481935

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PRR5L degradation promotes MTORC2-mediated PKCδ phosphorylation and cell migration downstream of Gα12

Autor: Chen Wang, Dario R. Alessi, Eeva Sommer, Melvin I. Simon, Dianqing Wu, Jiyong Wang, Stefan Offermanns, Tohru Kozasa, Xiaoqing Gan, Srinivasa M. Srinivasula

Publikováno v: Nature cell biology

Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates AGC protein kinases including protein kinase C (PKC) and regulates cellular functions such as cell migration. However, its regulation remains poorly understood. Here we show that lysopho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41ad46a8c75ee88c24915562e9ba901
http://europepmc.org/articles/PMC3389271

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Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Autor: Ayaz Najafov, M. Phillip DeYoung, Jeffrey M. Axten, Eeva Sommer, Dario R. Alessi

Publikováno v: Biochemical Journal. 433:357-369

PDK1 (3-phosphoinositide-dependent protein kinase 1) activates a group of protein kinases belonging to the AGC [PKA (protein kinase A)/PKG (protein kinase G)/PKC (protein kinase C)]-kinase family that play important roles in mediating diverse biologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f573355176a536f84d7369e02900230
https://doi.org/10.1042/bj20101732

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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Autor: Ruzica, Bago, Nazma, Malik, Michael J, Munson, Alan R, Prescott, Paul, Davies, Eeva, Sommer, Natalia, Shpiro, Richard, Ward, Darren, Cross, Ian G, Ganley, Dario R, Alessi

Publikováno v: Biochemical Journal

The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e482468dace2fe9575967a237a98adb3
https://pubmed.ncbi.nlm.nih.gov/25177796

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Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

Autor: Eeva Sommer, Laura R. Pearce, Kei Sakamoto, Stephan Wullschleger, Dario R. Alessi

Publikováno v: The Biochemical journal. 436(1)

The mTOR (mammalian target of rapamycin) protein kinase is an important regulator of cell growth and is a key target for therapeutic intervention in cancer. Two complexes of mTOR have been identified: complex 1 (mTORC1), consisting of mTOR, Raptor (r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5911a4c63edc440603be8f36980e5cc0
https://pubmed.ncbi.nlm.nih.gov/21413931

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Abstract A04: Characterization of VPS34-IN1, a specific inhibitor of Vps34 reveals that the phosphatidylinositol 3-phosphate binding SGK3 protein kinase is regulated by class III PI-3 kinase

Autor: Michael J. Munson, Paul Davies, Alan R. Prescott, Ruzica Bago, Eeva Sommer, Nazma Malik, Ian G. Ganley, Dario R. Alessi, Shpiro Natalia

Publikováno v: Molecular Cancer Therapeutics. 14:A04-A04

The Vps34 Class III phosphoinositide 3-kinase (PI3K) phosphorylates phosphatidylinositol (PtdIns) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1979160c446fff1b3b5d5ff1d247430
https://doi.org/10.1158/1538-8514.pi3k14-a04

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