Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Eesha Jamil"'
Autor:
Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar, Marc Symons
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-17 (2021)
Abstract Background Glioblastoma is the most common primary brain tumor and remains uniformly fatal, highlighting the dire need for developing effective therapeutics. Significant intra- and inter-tumor heterogeneity and inadequate delivery of therape
Externí odkaz:
https://doaj.org/article/c1a6ee476fc8474f99b9f1bb007fbe07
Autor:
Himanshu Brahmbhatt, Eesha Jamil, Camila Gonzalez, Steven Gao, Jennifer A. MacDiarmid, Jann N. Sarkaria, Muhammad Babar Khan, Marc Symons, Nhan L. Tran, Rosamaria Ruggieri, Nancy Mugridge, John A. Boockvar
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-17 (2021)
Molecular Medicine
Molecular Medicine
Background Glioblastoma is the most common primary brain tumor and remains uniformly fatal, highlighting the dire need for developing effective therapeutics. Significant intra- and inter-tumor heterogeneity and inadequate delivery of therapeutics acr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f44f66ba1afdee5518a6befb57c4c84
https://doi.org/10.1186/s10020-021-00293-4
https://doi.org/10.1186/s10020-021-00293-4
Autor:
Khan, Muhammad Babar, Ruggieri, Rosamaria, Eesha Jamil, Tran, Nhan L., Gonzalez, Camila, Mugridge, Nancy, Gao, Steven, MacDiarmid, Jennifer, Himanshu Brahmbhatt, Sarkaria, Jann N., Boockvar, John, Symons, Marc
Additional file 2: Table S2. List of miRNAs which regulate glioblastoma driver pathways. miRPATH v 3.0 was used to explore miRNAs which regulate driver pathways in glioma as described in KEGG database. miRNA–gene interactions cataloged in Tarbase v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63eb8b18e197fc280f46b10c23baf523
Autor:
Khan, Muhammad Babar, Ruggieri, Rosamaria, Eesha Jamil, Tran, Nhan L., Gonzalez, Camila, Mugridge, Nancy, Gao, Steven, MacDiarmid, Jennifer, Himanshu Brahmbhatt, Sarkaria, Jann N., Boockvar, John, Symons, Marc
Additional file 1: Table S1. List of genes predicted to be regulated by miR-34a in glioblastoma driver pathways. miRPATH v.3 was used to identify genes in the KEGG glioma pathway which are predicted to be regulated by miR-34a. miRNA-gene interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea5e0eeabbb5d63b7efda5c6db5acca
Autor:
Khan, Muhammad Babar, Ruggieri, Rosamaria, Eesha Jamil, Tran, Nhan L., Gonzalez, Camila, Mugridge, Nancy, Gao, Steven, MacDiarmid, Jennifer, Himanshu Brahmbhatt, Sarkaria, Jann N., Boockvar, John, Symons, Marc
Additional file 3: Table S3. miR-34a down-regulates multiple therapeutic resistance genes. GBM6, GBM118 and GBM126 primary cultures were transfected with 30 nM miR-34a or 30 nM miR-C. Total RNA was extracted 48 h post transfection and RT2 Profiler™
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c084762c8944beb346891d1e74611bf7
Autor:
Khan, Muhammad Babar, Ruggieri, Rosamaria, Eesha Jamil, Tran, Nhan L., Gonzalez, Camila, Mugridge, Nancy, Gao, Steven, MacDiarmid, Jennifer, Himanshu Brahmbhatt, Sarkaria, Jann N., Boockvar, John, Symons, Marc
Additional file 6: Figure S3. miR-34a downregulates multiple therapeutic resistance genes. A. Transfection with miR-34a significantly increases miR-34a expression in glioblastoma primary cultures. GBM6, GBM118 and GBM126 cells were transfected with 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5d7a592b4c7ed984ead93fc9ba4983
Autor:
Khan, Muhammad Babar, Ruggieri, Rosamaria, Eesha Jamil, Tran, Nhan L., Gonzalez, Camila, Mugridge, Nancy, Gao, Steven, MacDiarmid, Jennifer, Himanshu Brahmbhatt, Sarkaria, Jann N., Boockvar, John, Symons, Marc
Additional file 4: Figure S1. miR-34a modulates the expression of multiple signaling elements in glioma. The glioma pathway from KEGG (hsa05214) with miR-34a targets is illustrated. Yellow boxes represent genes whose expression has been reported to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d95ce429885ce190ec893a1cd687e51
Autor:
Khan, Muhammad Babar, Ruggieri, Rosamaria, Eesha Jamil, Tran, Nhan L., Gonzalez, Camila, Mugridge, Nancy, Gao, Steven, MacDiarmid, Jennifer, Himanshu Brahmbhatt, Sarkaria, Jann N., Boockvar, John, Symons, Marc
Additional file 8: Figure S5. Glioblastoma cultures have different baseline expression of therapeutic resistance gens. Total RNA was extracted from GBM6, GBM118 and GBM126 primary cultures and RT2 Profiler™ PCR Array from Qiagen was used to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376fd03ed3682cd0635b31b82b3309e4
Autor:
Khan, Muhammad Babar, Ruggieri, Rosamaria, Eesha Jamil, Tran, Nhan L., Gonzalez, Camila, Mugridge, Nancy, Gao, Steven, MacDiarmid, Jennifer, Himanshu Brahmbhatt, Sarkaria, Jann N., Boockvar, John, Symons, Marc
Additional file 7: Figure S4. High expression of miR-34a down-regulated therapeutic resistance genes is associated with worse survival. Kaplan-Meir curves for overall survival in 585 glioblastoma patients from TCGA dataset for the validated resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd73639225393326745d3f314ec9df6e