Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Eero Mäntylä"'
Publikováno v:
The Breast Journal. 8:92-96
The object of this article is to review briefly the preclinical and clinical safety of some antiestrogens. Tamoxifen, toremifene, droloxifene, and idoxifene are polyphenylethylene antiestrogens, whereas the pure antiestrogen, ICI 182,780 or faslodex,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9145e8f286c46a2ded268ea8e11ee497
https://doi.org/10.1046/j.1524-4741.2002.08204.x
https://doi.org/10.1046/j.1524-4741.2002.08204.x
Autor:
Stefan Karlsson, Pirkko Hirsimäki, Y. Hirsimäki, Sakari Toikkanen, Eero Mäntylä, Annukka Kärki
Publikováno v:
Archives of Toxicology. 74:249-256
The hepatoproliferative and cytochrome P450 enzyme inducing effects of two antiestrogens, tamoxifen and toremifene, were compared in female Sprague-Dawley rats using immunohistochemical staining methods. Equimolar doses of the antiestrogens (tamoxife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d13d1c9372e3db026906150673dcec
https://doi.org/10.1007/s002040000116
https://doi.org/10.1007/s002040000116
Publikováno v:
Chemico-Biological Interactions. 113:145-159
Binding of diethylstilbestrol and four different triphenylethylene derivatives: tamoxifen, toremifene, clomiphene and triparanol to DNA in rat liver, was studied using the 32P-postlabelling method with HPLC-radioactivity detection. Three different mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95892ff3874e4baa7ed6040ff81a3473
https://doi.org/10.1016/s0009-2797(98)00023-4
https://doi.org/10.1016/s0009-2797(98)00023-4
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 356:297-302
The aim of the present study was to investigate antioxidativity of the triphenylethylene antiestrogen toremifene. Toremifene and its structural analogues were studied for their ability to inhibit chain reactions of lipid peroxidation and to act as sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a65482ec69aa23a1079c1f92d2ba9b
https://doi.org/10.1007/pl00005054
https://doi.org/10.1007/pl00005054
Publikováno v:
Clinical Biochemistry. 29:139-144
Objectives: The present study describes new methods for the measurement of oxidation products and antioxidant potential of low density lipoproteins (LDL). Design and methods: LDL is isolated by precipitation with buffered heparin. The assay for LDL o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380bd00f972409598dd789e4e5d9e549
https://doi.org/10.1016/0009-9120(95)02043-8
https://doi.org/10.1016/0009-9120(95)02043-8
Publikováno v:
Carcinogenesis. 15:863-868
The triphenylethylene drug tamoxifen is a hepatocarcinogen in rats, has genotoxic potential and may produce carcinoma of the endometrium in humans, while the structurally closely related toremifene has no carcinogenic or genotoxic potential. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5721d044ad71a63340f6ddc8d1ed3af2
https://doi.org/10.1093/carcin/15.5.863
https://doi.org/10.1093/carcin/15.5.863
The effect of toremifene on bone and uterine histology and on bone resorption in ovariectomised rats
Autor:
Eero Mäntylä, Stefan Karlsson, Lauri Kangas, Kirsti Nieminen, Seija Niemi, Lauri Nieminen, Y. Hirsimäki
Publikováno v:
Pharmacologytoxicology. 84(2)
The effect of the selective oestrogen receptor modulator, toremifene, to inhibit ovariectomy-induced bone loss was studied in rats. The oral doses were 0.3, 3.0 or 30 mg/kg/day for 2 months. 17beta-oestradiol (5 microg/kg/day, subcutaneously) was use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfdff8daada887788c807a585fa7981
https://pubmed.ncbi.nlm.nih.gov/10068150
https://pubmed.ncbi.nlm.nih.gov/10068150
DNA binding of tamoxifen and its analogues: identification of the tamoxifen-DNA adducts in rat liver
Publikováno v:
Toxicology letters.
DNA binding of tamoxifen and some structurally-related drugs (toremifene, clomiphene, triparanol and raloxifene) in rat liver was studied using the 32 P-postlabelling method. As only tamoxifen was shown to form high levels of DNA adducts, the identit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d15b760c4ce64aeb03263840e767db
https://pubmed.ncbi.nlm.nih.gov/10022295
https://pubmed.ncbi.nlm.nih.gov/10022295
Autor:
P. Millar, M. Mulhern, C. J. Perry, Stefan Karlsson, Eero Mäntylä, J. Handa, Lauri Kangas, P. Hirsimäki, Gary M. Williams, Lauri Nieminen, Y. Hirsimäki
Publikováno v:
Drug and chemical toxicology. 19(4)
The carcinogenic potential of the nonsteroidal triphenylethylene antiestrogen toremifene (Fareston) was evaluated in a standard 104-week rat dietary carcinogenicity study. The doses were 0, 0.12, 1.2, 5.0 and 12 mg/kg/day and the number of animals 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b7df62960aee5f38b61772dccb734c
https://pubmed.ncbi.nlm.nih.gov/8972233
https://pubmed.ncbi.nlm.nih.gov/8972233
Publikováno v:
Hormonal Carcinogenesis II ISBN: 9781461275060
Induction of preneoplastic and neoplastic changes by two antiestrogenic drugs was studied in female rats. Groups of female rats were treated with tamoxifen citrate (TAM) (11.3 or 45 mg/kg) or toremifene citrate (TOR) (3, 12, or 48 mg/kg) by daily ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b01b988dff67194d3eb7a6341a17ca54
https://doi.org/10.1007/978-1-4612-2332-0_62
https://doi.org/10.1007/978-1-4612-2332-0_62
