Zobrazeno 1 - 10 of 309 pro vyhledávání: '"Eero, Castrén"'
1
Akademický článek
Brain Plasticity Modulator p75 Neurotrophin Receptor in Human Urine after Different Acute Brain Injuries—A Prospective Cohort Study
Autor: Santtu Hellström, Antti Sajanti, Abhinav Srinath, Carolyn Bennett, Romuald Girard, Ying Cao, Janek Frantzén, Fredrika Koskimäki, Johannes Falter, Seán B. Lyne, Tomi Rantamäki, Riikka Takala, Jussi P. Posti, Susanna Roine, Jukka Puolitaival, Miro Jänkälä, Sulo Kolehmainen, Melissa Rahi, Jaakko Rinne, Eero Castrén, Janne Koskimäki
Publikováno v: Biomedicines, Vol 12, Iss 1, p 112 (2024)
Acute brain injuries (ABIs) pose a substantial global burden, demanding effective prognostic indicators for outcomes. This study explores the potential of urinary p75 neurotrophin receptor (p75NTR) concentration as a prognostic biomarker, particularl
Externí odkaz: https://doaj.org/article/a83bd9a89d19490d8305c43d8fda22de
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2
Akademický článek
BDNF receptor TrkB as the mediator of the antidepressant drug action
Autor: Plinio Casarotto, Juzoh Umemori, Eero Castrén
Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)
Brain-derived neurotrophic factor (BDNF) signaling through its receptor TrkB has for a long time been recognized as a critical mediator of the antidepressant drug action, but BDNF signaling has been considered to be activated indirectly through the a
Externí odkaz: https://doaj.org/article/64104453e6dd4360be2d161f431c1618
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3
Akademický článek
Reduced evoked activity and cortical oscillations are correlated with anisometric amblyopia and impairment of visual acuity
Autor: Hanna Julku, Santeri Rouhinen, Henri J. Huttunen, Laura Lindberg, Johanna Liinamaa, Ville Saarela, Elina Karvonen, Sigrid Booms, Jyrki P. Mäkelä, Hannu Uusitalo, Eero Castrén, J. Matias Palva, Satu Palva
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Amblyopia is a developmental disorder associated with abnormal visual experience during early childhood commonly arising from strabismus and/or anisometropia and leading to dysfunctions in visual cortex and to various visual deficits. The di
Externí odkaz: https://doaj.org/article/39e07a83bf9a4b2bac09d66a3de96769
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4
Akademický článek
Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro
Autor: Senem Merve Fred, Suvi Kuivanen, Hasan Ugurlu, Plinio Cabrera Casarotto, Lev Levanov, Kalle Saksela, Olli Vapalahti, Eero Castrén
Publikováno v: Frontiers in Pharmacology, Vol 12 (2022)
Repurposing of currently available drugs is a valuable strategy to tackle the consequences of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on SARS-CoV-2 in cell culture models as well as in clinical practice.
Externí odkaz: https://doaj.org/article/0cd2d56649b04388869f8e290921e48b
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5
Akademický článek
Perineuronal Net Receptor PTPσ Regulates Retention of Memories
Autor: Angelina Lesnikova, Plinio Casarotto, Rafael Moliner, Senem Merve Fred, Caroline Biojone, Eero Castrén
Publikováno v: Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods of intensive learning, usually in late childhood, and they help in lon
Externí odkaz: https://doaj.org/article/03f5fb0774d44aa4a2294dc29547f850
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7
Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants
Autor: Elias Jetsonen, Giuliano Didio, Frederike Winkel, Maria Llach Pou, Chloe Boj, Laura Kuczynski-Noyau, Vootele Võikar, Ramon Guirado, Tomi Taira, Sari E. Lauri, Eero Castrén, Juzoh Umemori
Publikováno v: Neuropsychopharmacology. 48:1021-1030
SummaryCritical period-like plasticity (iPlasticity) can be reinstated in the adult brain by several interventions, including drugs and optogenetic modifications. We have demonstrated that a combination of iPlasticity with optimal training improves b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33705389cbe4934056f26e8f7650eb3e
https://doi.org/10.1038/s41386-023-01562-y
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8
Akademický článek
Depletion of TrkB Receptors From Adult Serotonergic Neurons Increases Brain Serotonin Levels, Enhances Energy Metabolism and Impairs Learning and Memory
Autor: Madhusmita P. Sahu, Yago Pazos-Boubeta, Anna Steinzeig, Katja Kaurinkoski, Michela Palmisano, Olgierd Borowecki, Timo Petteri Piepponen, Eero Castrén
Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)
Neurotrophin brain-derived neurotrophic factor (BDNF) and neurotransmitter serotonin (5-HT) regulate each other and have been implicated in several neuronal mechanisms, including neuroplasticity. We have investigated the effects of BDNF on serotonerg
Externí odkaz: https://doaj.org/article/2e04428e57ba411096daf434288f7bde
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10
Akademický článek
Facilitation of TRKB Activation by the Angiotensin II Receptor Type-2 (AT2R) Agonist C21
Autor: Liina Laukkanen, Cassiano R. A. F. Diniz, Sebastien Foulquier, Jos Prickaerts, Eero Castrén, Plinio C. Casarotto
Publikováno v: Pharmaceuticals, Vol 14, Iss 8, p 773 (2021)
Blockers of angiotensin II type 1 receptor (AT1R) exert antidepressant-like effects by indirectly facilitating the activation of the angiotensin II type 2 receptor (AT2R), which leads to increased surface expression and transactivation of tropomyosin
Externí odkaz: https://doaj.org/article/5e6b24cbe89043e590485d050b52c80c
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