Local delivery of hrBMP4 as an anticancer therapy in patients with recurrent glioblastoma: a first-in-human phase 1 dose escalation trial

Autor: Eelke M. Bos, Elena Binda, Iris S.C. Verploegh, Eva Wembacher, Daphna Hoefnagel, Rutger K. Balvers, Anne L. Korporaal, Andrea Conidi, Esther A. H. Warnert, Nadia Trivieri, Alberto Visioli, Paola Zaccarini, Laura Caiola, Rogier van Wijck, Peter van der Spek, Danny Huylebroeck, Sieger Leenstra, Martine L.M. Lamfers, Zvi Ram, Manfred Westphal, David Noske, Federico Legnani, Francesco DiMeco, Angelo Luigi Vescovi, Clemens M.F. Dirven

Publikováno v: Molecular Cancer, Vol 22, Iss 1, Pp 1-9 (2023)

Abstract Background This Phase 1 study evaluates the intra- and peritumoral administration by convection enhanced delivery (CED) of human recombinant Bone Morphogenetic Protein 4 (hrBMP4) – an inhibitory regulator of cancer stem cells (CSCs) – in

Externí odkaz: https://doaj.org/article/b6e88963f885415e8d912afbaecd0fc3

A Large Skull Defect Due to Gorham-Stout Disease: Case Report and Literature Review on Pathogenesis, Diagnosis, and Treatment

Autor: Catherine E. de Keyser, Michael S. Saltzherr, Eelke M. Bos, M. Carola Zillikens

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

A 24-year old man was referred to the Erasmus MC Bone Center because of an asymptomatic increasing skull defect of the left parietal bone. The defect was first noticed at the age of six, and gradually increased over the years. His medical history was

Externí odkaz: https://doaj.org/article/26bebd5f248e444fa1b6648bf8d5dec5

Impact of maximal extent of resection on postoperative deficits, patient functioning, and survival within clinically important glioblastoma subgroups

Autor: Jasper K W Gerritsen, Rosa H Zwarthoed, John L Kilgallon, Noah Lee Nawabi, Georges Versyck, Charissa A C Jessurun, Koen P Pruijn, Fleur L Fisher, Emma Larivière, Lien Solie, Rania A Mekary, Djaina D Satoer, Joost W Schouten, Eelke M Bos, Alfred Kloet, Rishi Nandoe Tewarie, Timothy R Smith, Clemens M F Dirven, Steven De Vleeschouwer, Arnaud J P E Vincent, Marike L D Broekman

Publikováno v: Neuro-Oncology, 25(5), 958-972. Oxford University Press

Background The impact of extent of resection (EOR), residual tumor volume (RTV), and gross-total resection (GTR) in glioblastoma subgroups is currently unknown. This study aimed to analyze their impact on patient subgroups in relation to neurological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec25831e12aca7c499d758d268990fa5
https://doi.org/10.1093/neuonc/noac255

The prevalence and severity of fatigue in meningioma patients and its association with patient-, tumor- and treatment-related factors

Autor: Kwong T Quach, Linda Dirven, Aliede M Vingerhoed, Jeroen de Bresser, Ruben Dammers, Eelke M Bos, Wouter A Moojen, Wilco C Peul, Martin J B Taphoorn, Amir H Zamanipoor Najafabadi, Wouter R van Furth

Publikováno v: Quach, K T, Dirven, L, Vingerhoed, A M, de Bresser, J, Dammers, R, Bos, E M, Moojen, W A, Peul, W C, Taphoorn, M J B, Zamanipoor Najafabadi, A H & van Furth, W R 2023, ' The prevalence and severity of fatigue in meningioma patients and its association with patient-, tumor-and treatment-related factors ', Neuro-oncology advances, vol. 5, no. 1, vdad056 . https://doi.org/10.1093/noajnl/vdad056

Background Fatigue is a commonly reported and severe symptom in primary brain tumor patients, but the exact occurrence in meningioma patients is unknown. This study aimed to determine the frequency and severity of fatigue in meningioma patients as we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7786fbb4391ac588f39ff06f21345447
https://doi.org/10.1093/noajnl/vdad056

Pro-Differentiation Anticancer Therapy Using Local Delivery of hrBMP4 in Patients with Recurrent Glioblastoma: A First-in-Human Phase 1 Dose Escalation Trial

Autor: Eelke M. Bos, Elena Binda, Iris S.C. Verploegh, Eva Wembacher-Schroeder, Daphna Hoefnagel, Rutger K. Balvers, Anne L. Korporaal, Andrea Conidi, Esther A.H. Warnert, Nadia Trivieri, Alberto Visioli, Paola Zaccarini, Laura Caiola, Rogier van Wijck, Peter J. van der Spek, Danny Huylebroeck, Sieger Leenstra, Martine L.M. Lamgers, Zvi Ram, Manfred Westphal, David Noske, Federico Legnani, Francesco DiMeco, Luigi Angelo Vescovi, Clemens M.F. Dirven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20cc81180e860d84eac98e1a092b5982
https://doi.org/10.2139/ssrn.4357994