Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ee Sin, Chen"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The detection of cancer-driving mutations is important for understanding cancer pathology and therapeutics development. Prediction tools have been created to streamline the computation process. However, most tools available have heterogeneou
Externí odkaz:
https://doaj.org/article/90b54d1762c04004b27a8eb2dea346a9
Autor:
Kim Kiat Lim, Ee Sin Chen
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103076- (2024)
Summary: Conventional colony-forming unit assay to measure cell viability is laborious and results in large experimental variability, which prohibits accurate quantification of microbial viability. Here, we present a microscopy-based protocol for the
Externí odkaz:
https://doaj.org/article/aa5180c065584208aef8c84a0c130a6d
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-20 (2022)
Abstract The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylation mark is essential for proper transcription, recombination, and DNA damage response. Loss- and gain-of-function muta
Externí odkaz:
https://doaj.org/article/1a37bd7da96549a9b3ff57e883da97f1
Autor:
Ulysses Tsz-Fung Lam, Thi Thuy Trang Nguyen, Raechell Raechell, Jay Yang, Harry Singer, Ee Sin Chen
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2829 (2023)
Edge effect denotes better growth of microbial organisms situated at the edge of the solid agar media. Although the precise reason underlying edge effect is unresolved, it is generally attributed to greater nutrient availability with less competing n
Externí odkaz:
https://doaj.org/article/818ce6701fa243039489ec4e4d0cd12c
Publikováno v:
BMC Medical Genomics, Vol 13, Iss S10, Pp 1-9 (2020)
Abstract Background Understanding the mechanisms underlying the malignant progression of cancer cells is crucial for early diagnosis and therapeutic treatment for cancer. Mutational heterogeneity of breast cancer suggests that about a dozen of cancer
Externí odkaz:
https://doaj.org/article/db7b52f138ef4e07822295066c1a4f82
Autor:
Siti Nurulnabila A. Rahaman, Jastina Mat Yusop, Zeti-Azura Mohamed-Hussein, Wan Mohd Aizat, Kok Lian Ho, Aik-Hong Teh, Jitka Waterman, Boon Keat Tan, Hwei Ling Tan, Adelicia Yongling Li, Ee Sin Chen, Chyan Leong Ng
Publikováno v:
PeerJ, Vol 6, p e5377 (2018)
Proteins of the DUF866 superfamily are exclusively found in eukaryotic cells. A member of the DUF866 superfamily, C1ORF123, is a human protein found in the open reading frame 123 of chromosome 1. The physiological role of C1ORF123 is yet to be determ
Externí odkaz:
https://doaj.org/article/bc1def684c2f4b02b705ee3ca6ffa74c
Autor:
Ee Sin Chen
Publikováno v:
FEMS yeast research.
Fission yeast Schizosaccharomyces pombe (S. pombe) is renowned as a powerful genetic model for deciphering cellular and molecular biological phenomena, including cell division, chromosomal events, stress responses, and human carcinogenesis. Tradition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd60db6f89003b1c85e7c900f672cf81
https://pubmed.ncbi.nlm.nih.gov/36574952
https://pubmed.ncbi.nlm.nih.gov/36574952
Autor:
Hwei Ling Tan, EE SIN CHEN
Publikováno v:
Genes; Volume 13; Issue 10; Pages: 1697
Precise chromosome segregation is essential for maintaining genomic stability, and its proper execution centers on the centromere, a chromosomal locus that mounts the kinetochore complex to mediate attachment of chromosomes to the spindle microtubule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84560f61a233e173ca502841a85f1d8
https://pubmed.ncbi.nlm.nih.gov/36292582
https://pubmed.ncbi.nlm.nih.gov/36292582
Publikováno v:
Epigeneticschromatin. 15(1)
The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylation mark is essential for proper transcription, recombination, and DNA damage response. Loss- and gain-of-function mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f611315238f952e7875965efeb6f7fa6
https://pubmed.ncbi.nlm.nih.gov/35581654
https://pubmed.ncbi.nlm.nih.gov/35581654
Autor:
Ee Sin Chen, Bingbing Ren
Publikováno v:
Current Genetics. 65:829-836
Constitutive heterochromatin packages long stretches of repetitive DNA sequences at the centromere and telomere, and ensures genomic integrity at these loci by preventing aberrant recombination and transcription. The chromatin scaffold of heterochrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15db1bb54f43a7438b2a8dcd1f82bba
https://doi.org/10.1007/s00294-019-00962-2
https://doi.org/10.1007/s00294-019-00962-2