Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Ee Sin"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The detection of cancer-driving mutations is important for understanding cancer pathology and therapeutics development. Prediction tools have been created to streamline the computation process. However, most tools available have heterogeneou
Externí odkaz:
https://doaj.org/article/90b54d1762c04004b27a8eb2dea346a9
Autor:
Kim Kiat Lim, Ee Sin Chen
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103076- (2024)
Summary: Conventional colony-forming unit assay to measure cell viability is laborious and results in large experimental variability, which prohibits accurate quantification of microbial viability. Here, we present a microscopy-based protocol for the
Externí odkaz:
https://doaj.org/article/aa5180c065584208aef8c84a0c130a6d
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-20 (2022)
Abstract The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylation mark is essential for proper transcription, recombination, and DNA damage response. Loss- and gain-of-function muta
Externí odkaz:
https://doaj.org/article/1a37bd7da96549a9b3ff57e883da97f1
Autor:
Ulysses Tsz-Fung Lam, Thi Thuy Trang Nguyen, Raechell Raechell, Jay Yang, Harry Singer, Ee Sin Chen
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2829 (2023)
Edge effect denotes better growth of microbial organisms situated at the edge of the solid agar media. Although the precise reason underlying edge effect is unresolved, it is generally attributed to greater nutrient availability with less competing n
Externí odkaz:
https://doaj.org/article/818ce6701fa243039489ec4e4d0cd12c
Autor:
Kim Kiat Lim, Nathaniel Zhi Hao Koh, Yi Bing Zeng, Jun Kai Chuan, Raechell Raechell, Ee Sin Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10687 (2023)
5-Fluorouracil (5-FU) is a conventional chemotherapeutic drug widely used in clinics worldwide, but development of resistance that compromises responsiveness remains a major hurdle to its efficacy. The mechanism underlying 5-FU resistance is conventi
Externí odkaz:
https://doaj.org/article/e1d20f9a112a45819bb949437d036feb
Publikováno v:
BMC Medical Genomics, Vol 13, Iss S10, Pp 1-9 (2020)
Abstract Background Understanding the mechanisms underlying the malignant progression of cancer cells is crucial for early diagnosis and therapeutic treatment for cancer. Mutational heterogeneity of breast cancer suggests that about a dozen of cancer
Externí odkaz:
https://doaj.org/article/db7b52f138ef4e07822295066c1a4f82
Autor:
Kim Kiat Lim, Hwei Yee Teo, Yuan Yee Tan, Yi Bing Zeng, Ulysses Tsz Fung Lam, Mahesh Choolani, Ee Sin Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 639 (2021)
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate metabolic pathway, and its loss of function through polymorphisms is often associated with human conditions, including cancer, congenital heart disease, and Down syndrome. MTHF
Externí odkaz:
https://doaj.org/article/f040bb4ec7eb4cfe9987d89581ce912f
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6175 (2020)
Centromere integrity underlies an essential framework for precise chromosome segregation and epigenetic inheritance. Although centromeric DNA sequences vary among different organisms, all eukaryotic centromeres comprise a centromere-specific histone
Externí odkaz:
https://doaj.org/article/9dc129af99904cc8b5d6892c4003b5b4
Autor:
Siti Nurulnabila A. Rahaman, Jastina Mat Yusop, Zeti-Azura Mohamed-Hussein, Wan Mohd Aizat, Kok Lian Ho, Aik-Hong Teh, Jitka Waterman, Boon Keat Tan, Hwei Ling Tan, Adelicia Yongling Li, Ee Sin Chen, Chyan Leong Ng
Publikováno v:
PeerJ, Vol 6, p e5377 (2018)
Proteins of the DUF866 superfamily are exclusively found in eukaryotic cells. A member of the DUF866 superfamily, C1ORF123, is a human protein found in the open reading frame 123 of chromosome 1. The physiological role of C1ORF123 is yet to be determ
Externí odkaz:
https://doaj.org/article/bc1def684c2f4b02b705ee3ca6ffa74c
Autor:
Zoey Tay, Ru Jun Eng, Kenichi Sajiki, Kim Kiat Lim, Ming Yi Tang, Mitsuhiro Yanagida, Ee Sin Chen
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55041 (2013)
Doxorubicin is an anthracycline antibiotic that is among one of the most commonly used chemotherapeutic agents in the clinical setting. The usage of doxorubicin is faced with many problems including severe side effects and chemoresistance. To overcom
Externí odkaz:
https://doaj.org/article/a69922088536450aafc248adcf8dc987