Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ee Ling Teo"'
Autor:
Stéphanie Blanchard, Mohammed Khalid Pasha, Harish Kumar Mysore Nagaraj, Eric T. Sun, Changyong Hu, Anthony D. William, Chai Ping Lee, Anders Poulsen, Ramesh Jayaraman, Meredith Williams, Jeanette Marjorie Wood, Kee Chuan Goh, Kantharaj Ethirajulu, Angeline C.-H. Lee, Haishan Wang, Ee Ling Teo, Brian Dymock
Publikováno v:
Journal of Medicinal Chemistry. 55:169-196
Herein, we describe the design, synthesis, and SAR of a series of unique small molecule macrocycles that show spectrum selective kinase inhibition of CDKs, JAK2, and FLT3. The most promising leads were assessed in vitro for their inhibition of cancer
Autor:
Anders Poulsen, Kee Chuan Goh, Ee Ling Teo, Chee Pang Ng, Stéphanie Blanchard, Evelyn Tan, Wai Chung Ong, Kay Lin Goh, Weiping Deng, Angeline C.-H. Lee, Eric T. Sun, Anthony D. William, Noah Tu, Zahid Bonday
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2443-2447
A series of alkenyl indazoles were synthesized and evaluated in Aurora kinase enzyme assays. Several promising leads were optimized for selectivity towards Aurora B. Excellent binding affinity and good selectivity were achieved with optimized compoun
Publikováno v:
Catalysis Today. 97:263-270
Kinetic resolution of racemates with the help of enzymes has become a widely adopted method for the synthesis of chiral intermediates and compounds with biological activity. However, the inherent limitation to 50% yield of any one stereoisomer restri
Autor:
Ramesh Jayaraman, Mohammed Khalid Pasha, Angeline C.-H. Lee, Kee Chuan Goh, Eric T. Sun, Anthony D. William, Dizhong Chen, Meredith Williams, Siok Kun Goh, Jeanette Marjorie Wood, Kantharaj Ethirajulu, Stefan Hart, Wai Chung Ong, Evelyn Tan, Stéphanie Blanchard, Anders Poulsen, Ee Ling Teo, Brian Dymock, Harish Kumar Mysore Nagaraj
Publikováno v:
Journal of medicinal chemistry. 54(13)
Discovery of the activating mutation V617F in Janus Kinase 2 (JAK2(V617F)), a tyrosine kinase critically involved in receptor signaling, recently ignited interest in JAK2 inhibitor therapy as a treatment for myelofibrosis (MF). Herein, we describe th
Autor:
Kee Chuan Goh, Ramesh Jayaraman, Kantharaj Ethirajulu, Anders Poulsen, Kay Lin Goh, Mohammed Khalid Pasha, Angeline Lee, Wai Chung Ong, Harish Kumar Mysore Nagaraj, Brian W. Dymock, Jeanette Marjorie Wood, Ee Ling Teo, Stéphanie Blanchard, Eric T. Sun, Anthony D. William
Publikováno v:
Cancer Research. 71:3591-3591
Introduction: During our quest to find novel kinase inhibitor motifs for our protein kinase research projects we discovered a novel series of macrocyclic structures which possess unique but tunable kinase inhibitory profiles. Here we present the chem