Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Edzna Garcia"'
Autor:
Zoran Radić, Palmer Taylor, Valery V. Fokin, Limin Zhang, Suzana Berend, Gabriel Amitai, K. Barry Sharpless, Edzna Garcia, Rakesh K. Sit, Zrinka Kovarik
Publikováno v:
Chemico-Biological Interactions. 203:67-71
A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. N-substituted 2-hydroxyiminoacet
Autor:
Zrinka Kovarik, Trevor J. Dale, Božica Radić, Gabriel Amitai, Dariush Ajami, Julius Rebek, Suzana Berend, Zoran Radić, Edzna Garcia, Limin Zhang, Palmer Taylor, Carol E. Green, Brendan M. Duggan
Publikováno v:
Biochemical Journal. 450:231-242
In the present paper we show a comprehensive in vitro , ex vivo and in vivo study on hydrolytic detoxification of nerve agent and pesticide OPs (organophosphates) catalysed by purified hBChE (human butyrylcholinesterase) in combination with novel non
Autor:
Gabriel Amitai, K. Barry Sharpless, Tuba Tüylü Küçükkılınç, Palmer Taylor, Valery V. Fokin, Jaroslaw Kalisiak, Edzna Garcia, Zoran Radić, Zrinka Kovarik, Rory L. Cochran, Kwok-Yiu Ho, Limin Zhang
Publikováno v:
Journal of Biological Chemistry. 286:29718-29724
The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Exposure to OPs can lead to serious cardiovascular complications, respiratory compromise, and death. Current therapy to combat
Autor:
Zoran Radić, Anne Marie Valle, Rory L. Cochran, Gabi Amitai, Tuba Tüylü Küçükkılınç, Palmer Taylor, Edzna Garcia, Jaroslaw Kalisiak
Publikováno v:
Chemico-Biological Interactions. 187:238-240
Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have been recently considered for t
Autor:
Zoran Radić, Palmer Taylor, Gabriel Amitai, K. Barry Sharpless, Rakesh K. Sit, Limin Zhang, Suzana Berend, Edzna Garcia, Valery Fokin, Zrinka Kovarik
Publikováno v:
The FASEB Journal. 26
Autor:
Rakesh K. Sit, Zoran Radić, Božica Radić, Suzana Berend, Edzna Garcia, Gabriel Amitai, K. Barry Sharpless, Carol E. Green, Limin Zhang, Palmer Taylor, Zrinka Kovarik, Valery V. Fokin
We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd658f00be38d81b0e7bc5d70dfe200d
https://europepmc.org/articles/PMC3320928/
https://europepmc.org/articles/PMC3320928/
Autor:
Gabriel Amitai, K. Barry Sharpless, Rakesh K. Sit, Zoran Radić, Edzna Garcia, Maja Katalinić, Palmer Taylor, Limin Zhang, Valery V. Fokin, Valeria Gerardi, Zrinka Kovarik
Publikováno v:
The Journal of biological chemistry. 286(22)
We describe here the synthesis and activity of a new series of oxime reactivators of cholinesterases (ChEs) that contain tertiary amine or imidazole protonatable functional groups. Equilibration between the neutral and protonated species at physiolog