Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Edze R. Westra"'
Autor:
Ellinor O. Alseth, Rafael Custodio, Sarah A. Sundius, Rachel A. Kuske, Sam P. Brown, Edze R. Westra
Publikováno v:
PLoS Biology, Vol 22, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/770319cfee3b433c9f762b746380b0b6
Publikováno v:
MethodsX, Vol 10, Iss , Pp 101941- (2023)
Bacteria have a broad array of defence mechanisms to fight bacteria-specific viruses (bacteriophages, phages) and other invading mobile genetic elements. Among those mechanisms, the ‘CRISPR-Cas’ (Clustered Regularly Interspaced Short Palindromic
Externí odkaz:
https://doaj.org/article/757e9f7dc9ff43dd9f4d319591514b79
Autor:
Bridget N. J. Watson, Reuben B. Vercoe, George P. C. Salmond, Edze R. Westra, Raymond H. J Staals, Peter C. Fineran
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Bacteria use CRISPR-Cas systems to protect themselves against viral infections. Here, Watson et al. show that a type I CRISPR-Cas system can induce abortive viral infection, where infected cells do not survive but viral propagation is decreased, thus
Externí odkaz:
https://doaj.org/article/b996789f39844bb4b36543b9bbb48b95
Autor:
David Walker-Sünderhauf, Uli Klümper, Elizabeth Pursey, Edze R. Westra, William H. Gaze, Stineke van Houte
Publikováno v:
Microbiology. 169
Antimicrobial resistance (AMR) genes are widely disseminated on plasmids. Therefore, interventions aimed at blocking plasmid uptake and transfer may curb the spread of AMR. Previous studies have used CRISPR-Cas-based technology to remove plasmids enc
Organisms have evolved a range of constitutive (always active) and inducible (elicited by parasites) defence mechanisms, but we have limited understanding of what drives the evolution of these orthogonal defence strategies. Bacteria and their phages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d9100c536207f86e43c44b409760b4c
https://doi.org/10.1101/2023.04.14.536855
https://doi.org/10.1101/2023.04.14.536855
Autor:
Alice Maestri, Elizabeth Pursey, Charlotte Chong, Benoit J. Pons, Sylvain Gandon, Rafael Custodio, Matthew Chisnall, Anita Grasso, Steve Paterson, Kate Baker, Stineke van Houte, Anne Chevallereau, Edze R. Westra
SummaryThe constant arms race between bacteria and their phages has resulted in a large diversity of bacterial defence systems1,2, with many bacteria carrying several systems3,4. In response, phages often carry counter-defence genes5–9. If and how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::514aa8aa488cd498082bddf4b20eedb9
https://doi.org/10.1101/2023.03.30.534895
https://doi.org/10.1101/2023.03.30.534895
Publikováno v:
Nature Reviews Microbiology. 20:49-62
We commonly acknowledge that bacterial viruses (phages) shape the composition and evolution of bacterial communities in nature and therefore have important roles in ecosystem functioning. This view stems from studies in the 1990s to the first decade
Autor:
Anne Chevallereau, Edze R. Westra
Publikováno v:
Current biology : CB. 32(17)
A new study reports that phage-inducible chromosomal islands (PICIs) are hotspots of defence systems against phages, other PICIs and plasmids. This discovery highlights how competition between mobile genetic elements shapes bacterial defence gene rep
It is becoming increasingly clear that antibiotics can both positively and negatively impact the infectivity of bacteriophages (phage), but the underlying mechanisms often remain unclear. Here we demonstrate that antibiotics that target the protein t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ea1293342cfe6e4964f8540581b2b5
https://doi.org/10.1101/2022.09.07.506948
https://doi.org/10.1101/2022.09.07.506948
SummaryBackgroundE. coli is a highly diverse species that generates a huge global burden of antimicrobial-resistant infections. Although it is one of the most well-studied model organisms, we lack a synthesis of the genomic distribution of antimicrob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3cb6c673a4996ada6e6726317237169
https://doi.org/10.1101/2022.08.05.22278465
https://doi.org/10.1101/2022.08.05.22278465