Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Edze R. Westra"'
Autor:
Ellinor O Alseth, Rafael Custodio, Sarah A Sundius, Rachel A Kuske, Sam P Brown, Edze R Westra
Publikováno v:
PLoS Biology, Vol 22, Iss 4, p e3002346 (2024)
Where there are bacteria, there will be bacteriophages. These viruses are known to be important players in shaping the wider microbial community in which they are embedded, with potential implications for human health. On the other hand, bacteria pos
Externí odkaz:
https://doaj.org/article/003838e7653649019da704f1365eedf2
Publikováno v:
MethodsX, Vol 10, Iss , Pp 101941- (2023)
Bacteria have a broad array of defence mechanisms to fight bacteria-specific viruses (bacteriophages, phages) and other invading mobile genetic elements. Among those mechanisms, the ‘CRISPR-Cas’ (Clustered Regularly Interspaced Short Palindromic
Externí odkaz:
https://doaj.org/article/757e9f7dc9ff43dd9f4d319591514b79
Autor:
Bridget N. J. Watson, Reuben B. Vercoe, George P. C. Salmond, Edze R. Westra, Raymond H. J Staals, Peter C. Fineran
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Bacteria use CRISPR-Cas systems to protect themselves against viral infections. Here, Watson et al. show that a type I CRISPR-Cas system can induce abortive viral infection, where infected cells do not survive but viral propagation is decreased, thus
Externí odkaz:
https://doaj.org/article/b996789f39844bb4b36543b9bbb48b95
Autor:
Erin L Attrill, Rory Claydon, Urszula Łapińska, Mario Recker, Sean Meaden, Aidan T Brown, Edze R Westra, Sarah V Harding, Stefano Pagliara
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001406 (2021)
Bacteriophages represent an avenue to overcome the current antibiotic resistance crisis, but evolution of genetic resistance to phages remains a concern. In vitro, bacteria evolve genetic resistance, preventing phage adsorption or degrading phage DNA
Externí odkaz:
https://doaj.org/article/a10eff5e12c94ff8a153cfc15a290d0a
Autor:
David Walker-Sünderhauf, Uli Klümper, Elizabeth Pursey, Edze R. Westra, William H. Gaze, Stineke van Houte
Publikováno v:
Microbiology. 169
Antimicrobial resistance (AMR) genes are widely disseminated on plasmids. Therefore, interventions aimed at blocking plasmid uptake and transfer may curb the spread of AMR. Previous studies have used CRISPR-Cas-based technology to remove plasmids enc
Organisms have evolved a range of constitutive (always active) and inducible (elicited by parasites) defence mechanisms, but we have limited understanding of what drives the evolution of these orthogonal defence strategies. Bacteria and their phages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d9100c536207f86e43c44b409760b4c
https://doi.org/10.1101/2023.04.14.536855
https://doi.org/10.1101/2023.04.14.536855
Autor:
Alice Maestri, Elizabeth Pursey, Charlotte Chong, Benoit J. Pons, Sylvain Gandon, Rafael Custodio, Matthew Chisnall, Anita Grasso, Steve Paterson, Kate Baker, Stineke van Houte, Anne Chevallereau, Edze R. Westra
SummaryThe constant arms race between bacteria and their phages has resulted in a large diversity of bacterial defence systems1,2, with many bacteria carrying several systems3,4. In response, phages often carry counter-defence genes5–9. If and how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::514aa8aa488cd498082bddf4b20eedb9
https://doi.org/10.1101/2023.03.30.534895
https://doi.org/10.1101/2023.03.30.534895
Autor:
Hélène Chabas, Sébastien Lion, Antoine Nicot, Sean Meaden, Stineke van Houte, Sylvain Moineau, Lindi M Wahl, Edze R Westra, Sylvain Gandon
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2006738 (2018)
The emergence and re-emergence of pathogens remains a major public health concern. Unfortunately, when and where pathogens will (re-)emerge is notoriously difficult to predict, as the erratic nature of those events is reinforced by the stochastic nat
Externí odkaz:
https://doaj.org/article/54a86ab65d064ce1a8cf60aa3525630f
Publikováno v:
PLoS Pathogens, Vol 14, Iss 6, p e1006990 (2018)
Externí odkaz:
https://doaj.org/article/b98a6967c8ae4c9ab5d879854443148d
Publikováno v:
Nature Reviews Microbiology. 20:49-62
We commonly acknowledge that bacterial viruses (phages) shape the composition and evolution of bacterial communities in nature and therefore have important roles in ecosystem functioning. This view stems from studies in the 1990s to the first decade