PB1999: TOBACCO SMOKING IN MDS PATIENTS – ANALYSIS FROM THE MDS PALG REGISTRY

Autor: Rafal Machowicz, Karol Lis, Jagoda Rytel, Anna Jachalska, Pawel Szwedyk, Oktawia Sosnia, Elzbieta Wiater, Agata Obara, Dorota Krochmalczyk, Anna Kopinska, Malgorzata Gajewska, Anna Masternak, Agnieszka Kopacz, Magdalena Olszewska-Szopa, Aleksandra Golos, Edyta Subocz, Joanna Drozd-Sokolowska, Grzegorz Basak, Krzysztof Mądry

Publikováno v: HemaSphere, Vol 7, p e2672439 (2023)

Externí odkaz: https://doaj.org/article/73977ca96c9e404898ba5dc4716881fd

Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization

Autor: Esther Clavero, José Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belém Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A. T. Hildebrandt, Niels Weinhold, Gabriele Buda, Ramón García-Sanz, Waldemar Tomczak, Ulla Vogel, Andrés Jerez, Daria Zawirska, Marzena Wątek, Jonathan N. Hofmann, Stefano Landi, John J. Spinelli, Aleksandra Butrym, Abhishek Kumar, Joaquín Martínez-López, Sara Galimberti, María Eugenia Sarasquete, Edyta Subocz, Elzbieta Iskierka-Jażdżewska, Graham G. Giles, Malwina Rybicka-Ramos, Marcin Kruszewski, Niels Abildgaard, Francisco García Verdejo, Pedro Sánchez Rovira, Miguel Inacio da Silva Filho, Katalin Kadar, Małgorzata Razny, Wendy Cozen, Matteo Pelosini, Manuel Jurado, Parveen Bhatti, Marek Dudzinski, Agnieszka Druzd-Sitek, Enrico Orciuolo, Yang Li, Aaron D. Norman, Jan Maciej Zaucha, Rui Manuel Reis, Miroslaw Markiewicz, Juan José Rodríguez Sevilla, Vibeke Andersen, Krzysztof Jamroziak, Kari Hemminki, Sonja I. Berndt, Vicent Rajkumar, Grzegorz Mazur, Shaji K. Kumar, Paula Ludovico, Arnon Nagler, Stephen J. Chanock, Charles Dumontet, Mitchell J. Machiela, Judit Varkonyi, Nicola J. Camp, Elad Ziv, Annette Juul Vangsted, Elizabeth E. Brown, Daniele Campa, Celine M. Vachon, Mihai G. Netea, Federico Canzian, Asta Försti, Juan Sainz

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 10, p 8500 (2023)

Multiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins

Externí odkaz: https://doaj.org/article/aa9ac778adcb44f8af0c75e4b483b12d

The role of NPM1 alternative splicing in patients with chronic lymphocytic leukemia.

Autor: Monika Szelest, Marta Masternak, Małgorzata Zając, Michał Chojnacki, Katarzyna Skórka, Joanna Zaleska, Agnieszka Karczmarczyk, Grażyna Stasiak, Ewa Wawrzyniak, Aleksandra Kotkowska, Monika Siemieniuk-Ryś, Joanna Purkot, Edyta Subocz, Edyta Cichocka, Waldemar Tomczak, Daria Zawirska, Krzysztof Giannopoulos

Publikováno v: PLoS ONE, Vol 17, Iss 10, p e0276674 (2022)

ObjectivesChronic lymphocytic leukemia (CLL) is a lymphoproliferative disease with heterogeneous clinical course. Recent studies revealed a link between NOTCH1 mutation and the overexpression of MYC and MYC-related genes involved in ribosome biogenes

Externí odkaz: https://doaj.org/article/c090ad7b145c4387b17bc511ab417c17

A pleiotropic variant in DNAJB4 is associated with multiple myeloma risk

Autor: Marco Dicanio, Matteo Giaccherini, Alyssa Clay‐Gilmour, Angelica Macauda, Juan Sainz, Mitchell J. Machiela, Malwina Rybicka‐Ramos, Aaron D. Norman, Agata Tyczyńska, Stephen J. Chanock, Torben Barington, Shaji K. Kumar, Parveen Bhatti, Wendy Cozen, Elizabeth E. Brown, Anna Suska, Eva K. Haastrup, Robert Z. Orlowski, Marek Dudziński, Ramon Garcia‐Sanz, Marcin Kruszewski, Joaquin Martinez‐Lopez, Katia Beider, Elżbieta Iskierka‐Jazdzewska, Matteo Pelosini, Sonja I. Berndt, Małgorzata Raźny, Krzysztof Jamroziak, S. Vincent Rajkumar, Artur Jurczyszyn, Annette Juul Vangsted, Pilar Garrido Collado, Ulla Vogel, Jonathan N. Hofmann, Mario Petrini, Aleksandra Butrym, Susan L. Slager, Elad Ziv, Edyta Subocz, Graham G. Giles, Niels Frost Andersen, Grzegorz Mazur, Marzena Watek, Fabienne Lesueur, Michelle A. T. Hildebrandt, Daria Zawirska, Lene Hyldahl Ebbesen, Herlander Marques, Federica Gemignani, Charles Dumontet, Judit Várkonyi, Gabriele Buda, Arnon Nagler, Agnieszka Druzd‐Sitek, Xifeng Wu, Katalin Kadar, Nicola J. Camp, Norbert Grzasko, Rosalie G. Waller, Celine Vachon, Federico Canzian, Daniele Campa

Publikováno v: Dicanio, M, Giaccherini, M, Clay-Gilmour, A, Macauda, A, Sainz, J, Machiela, M J, Rybicka-Ramos, M, Norman, A D, Tyczyńska, A, Chanock, S J, Barington, T, Kumar, S K, Bhatti, P, Cozen, W, Brown, E E, Suska, A, Haastrup, E K, Orlowski, R Z, Dudziński, M, Garcia-Sanz, R, Kruszewski, M, Martinez-Lopez, J, Beider, K, Iskierka-Jazdzewska, E, Pelosini, M, Berndt, S I, Raźny, M, Jamroziak, K, Rajkumar, S V, Jurczyszyn, A, Vangsted, A J, Collado, P G, Vogel, U, Hofmann, J N, Petrini, M, Butrym, A, Slager, S L, Ziv, E, Subocz, E, Giles, G G, Andersen, N F, Mazur, G, Watek, M, Lesueur, F, Hildebrandt, M A T, Zawirska, D, Ebbesen, L H, Marques, H, Gemignani, F, Dumontet, C, Várkonyi, J, Buda, G, Nagler, A, Druzd-Sitek, A, Wu, X, Kadar, K, Camp, N J, Grzasko, N, Waller, R G, Vachon, C, Canzian, F & Campa, D 2023, ' A pleiotropic variant in DNAJB4 is associated with multiple myeloma risk ', International Journal of Cancer, vol. 152, no. 2, pp. 239-248 . https://doi.org/10.1002/ijc.34278

Pleiotropy, which consists of a single gene or allelic variant affecting multiple unrelated traits, is common across cancers, with evidence for genome-wide significant loci shared across cancer and noncancer traits. This feature is particularly relev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32837a0c51884be8e4eff22a1b4fa8ed
https://doi.org/10.1002/ijc.34278

Response to anti‐SARS‐CoV ‐2 mRNA vaccines in multiple myeloma and chronic lymphocytic leukemia patients

Autor: Joanna Zaleska, Paulina Kwasnik, Magdalena Paziewska, Joanna Purkot, Aleksandra Szabelak, Mateusz Jurek, Natalia Masny, Izabela Dziatkiewicz, Bartosz Pronobis‐Szczylik, Agnieszka Piebiak, Agnieszka Szymczyk, Katarzyna Jarosz‐Chudzik, Lukasz Bolkun, Katarzyna Kozlowska, Jaroslaw Piszcz, Edyta Subocz, Janusz Halka, Michal Bator, Elzbieta Kalicinska, Tomasz Wrobel, Lidia Usnarska‐Zubkiewicz, Justyna Rybka, Izabela Deren‐Wagemann, Marta Szyca‐Smieszniak, Jaroslaw Dybko, Iwona Hus, Bartosz Pula, Edyta Cichocka, Marcin Rymko, Dorota Zdunczyk, Mateusz Ziarkiewicz, Grzegorz Wladyslaw Basak, Lars Bullinger, Krzysztof Giannopoulos

Publikováno v: International Journal of Cancer. 152:705-712

Multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) patients have increased morbidity and mortality rates of COVID-19 due to immunosuppression associated with the disease and ongoing therapy. The same immune impairment accompanying CLL and M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f107915f24b92f8fe7b03f5d7aaebc
https://doi.org/10.1002/ijc.34209