Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder.

Autor: Esther R Berko, Masako Suzuki, Faygel Beren, Christophe Lemetre, Christine M Alaimo, R Brent Calder, Karen Ballaban-Gil, Batya Gounder, Kaylee Kampf, Jill Kirschen, Shahina B Maqbool, Zeineen Momin, David M Reynolds, Natalie Russo, Lisa Shulman, Edyta Stasiek, Jessica Tozour, Maria Valicenti-McDermott, Shenglong Wang, Brett S Abrahams, Joseph Hargitai, Dov Inbar, Zhengdong Zhang, Joseph D Buxbaum, Sophie Molholm, John J Foxe, Robert W Marion, Adam Auton, John M Greally

Publikováno v: PLoS Genetics, Vol 10, Iss 5, p e1004402 (2014)

DNA mutational events are increasingly being identified in autism spectrum disorder (ASD), but the potential additional role of dysregulation of the epigenome in the pathogenesis of the condition remains unclear. The epigenome is of interest as a pos

Externí odkaz: https://doaj.org/article/a803dd8795744243ae732bdcac7b9739

Comparative isoschizomer profiling of cytosine methylation: the HELP assay

Autor: Eli Hatchwell, Batbayar Khulan, Roland Green, Quan Chen, Kenny Ye, Maria E. Figueroa, Masako Suzuki, Ari Melnick, Todd Richmond, Rebecca R. Selzer, John M. Greally, Edyta Stasiek, Cristina Montagna, Reid F. Thompson, Jacob L. Glass, Melissa Fazzari

Publikováno v: Batbayar, K, Thompson, R F, Ye, K, Fazzari, M J, Suzuki, M, Stasiek, E, Figueroa, M E, Glass, J L, Chen, Q, Montagna, C, Hatchwell, E, Selzer, R R, Richmond, T A, Green, R D, Melnick, A & Greally, J M 2006, ' Comparative isoschizomer profiling of cytosine methylation : the HELP assay ', Genome Research, vol. 16, no. 8, pp. 1046-55 . https://doi.org/10.1101/gr.5273806

The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its methylation-insensitive isoschizomer. This assay, termed HELP (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee184361e2be3d48fa04bf254fa9bc8
https://pubmed.ncbi.nlm.nih.gov/16809668

Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder

Autor: Sophie Molholm, Zeineen Momin, Joseph D. Buxbaum, Karen Ballaban-Gil, Faygel Beren, Dov Inbar, Joseph Hargitai, John J. Foxe, Adam Auton, Masako Suzuki, Zhengdong D. Zhang, Jill Kirschen, Christophe Lemetre, John M. Greally, Robert W. Marion, David Reynolds, Maria Valicenti-McDermott, Brett S. Abrahams, Batya Gounder, Natalie Russo, Shahina Maqbool, Shenglong Wang, Jessica Tozour, Edyta Stasiek, Christine M. Alaimo, Kaylee Kampf, Lisa H. Shulman, R. Brent Calder, Esther R. Berko

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 10, Iss 5, p e1004402 (2014)

DNA mutational events are increasingly being identified in autism spectrum disorder (ASD), but the potential additional role of dysregulation of the epigenome in the pathogenesis of the condition remains unclear. The epigenome is of interest as a pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077f60a0fba2df600217b78b6f6989b5
https://doi.org/10.1371/journal.pgen.1004402