Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Edyta Koscianska"'
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6089 (2021)
Non-coding RNAs (ncRNAs) have been reported to be implicated in cell fate determination and various human diseases. All ncRNA molecules are emerging as key regulators of diverse cellular processes; however, little is known about the regulatory intera
Externí odkaz:
https://doaj.org/article/9b2fc29ac8764677928eb4a291e00549
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 18741-18751 (2015)
Polyglutamine diseases, including Huntington’s disease and a number of spinocerebellar ataxias, are caused by expanded CAG repeats that are located in translated sequences of individual, functionally-unrelated genes. Only mutant proteins containing
Externí odkaz:
https://doaj.org/article/c72d83fe3fb044719957eddaf068f0f9
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 8, Pp 16999-17016 (2013)
With the advent of deep sequencing technology, a variety of miRNA length and sequence variants, termed isomiRNAs (isomiRs), have been discovered. However, the functional roles of these commonly detected isomiRs remain unknown. In this paper, we demon
Externí odkaz:
https://doaj.org/article/522e88f968c44ba3b8f283b35ac7c16f
Publikováno v:
The Scientific World Journal, Vol 11, Pp 102-117 (2011)
This protocol describes how to perform northern blot analyses to detect microRNAs and their precursors with single-nucleotide resolution, which is crucial for analyzing individual length variants and for evaluating relative quantities of unique micro
Externí odkaz:
https://doaj.org/article/6a69e369596b4516b400e7fd283efb27
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28548 (2011)
One of the cellular functions of the ribonuclease Dicer is to process microRNA precursors (pre-miRNAs) into mature microRNAs (miRNAs). Human Dicer performs this function in cooperation with its protein partners, AGO2, PACT and TRBP. The exact role of
Externí odkaz:
https://doaj.org/article/486873887e894dc59109f9ae253403ff
Publikováno v:
RNA Biology
MicroRNA (miRNA)-mediated crosstalk between coding and non-coding RNAs of various types is known as the competing endogenous RNA (ceRNA) concept. Here, we propose that there is a specific variant of the ceRNA language that takes advantage of simple s
Autor:
Izabela Szczerbal, S. Salamon, Joanna Nowacka-Woszuk, Edyta Koscianska, Marek Switonski, Maciej Szydlowski, B. Kociucka, M. Bartz
Publikováno v:
Livestock Science. 182:54-57
The miR-30 gene family includes potential regulators of adipogenesis. We searched for polymorphism in this gene family in 4 pig breeds: Duroc, Pietrain, Polish Landrace (PL), Polish Large White (PLW) and a synthetic line (L990). Altogether 5 single n
Autor:
Edyta Koscianska, Marzena Wojciechowska, Wlodzimierz J. Krzyzosiak, Emilia Kozlowska, Tomasz M. Witkos
Publikováno v:
Nucleic Acids Research
The fundamental role of microRNAs (miRNAs) in the regulation of gene expression has been well-established, but many miRNA-driven regulatory mechanisms remain elusive. In the present study, we demonstrate that miRNAs regulate the expression of DMPK, t
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 18741-18751 (2015)
International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 18741-18751 (2015)
Polyglutamine diseases, including Huntington’s disease and a number of spinocerebellar ataxias, are caused by expanded CAG repeats that are located in translated sequences of individual, functionally-unrelated genes. Only mutant proteins containing
Publikováno v:
Cellular and Molecular Life Sciences
The human genome contains more than 1,000 microRNA (miRNA) genes, which are transcribed mainly by RNA polymerase II. The canonical pathway of miRNA biogenesis includes the nuclear processing of primary transcripts (pri-miRNAs) by the ribonuclease Dro