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Exploring GPCR‐arrestin interfaces with genetically encoded crosslinkers

Autor: Christian Ihling, Stefan Ernicke, Robert Serfling, Vsevolod V. Gurevich, Andrea Sinz, Thore Böttke, Edyta Burda, Irene Coin

Publikováno v: EMBO Reports

β‐arrestins (βarr1 and βarr2) are ubiquitous regulators of G protein‐coupled receptor (GPCR) signaling. Available data suggest that β‐arrestins dock to different receptors in different ways. However, the structural characterization of GPCR�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414442f722ead0933e525720b85735d8
https://doi.org/10.15252/embr.202050437

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Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water

Autor: Harald Gröger, Svenja Staudt, Carolin Giese, Werner Hummel, Karlheinz Drauz, Christina Andrea Müller, Ulrich Schwaneberg, Edyta Burda, Jan Marienhagen

Publikováno v: Angewandte Chemie International Edition. 52:2359-2363

It doesn't take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP(+) (and a little 2-propanol to reduce it), as well as two catalytic enzymes-a hydroxyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542b5f5b650bb4d2160aa28d77d761fd
https://doi.org/10.1002/anie.201204464

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Combination of a Suzuki cross-coupling reaction using a water-soluble palladium catalyst with an asymmetric enzymatic reduction towards a one-pot process in aqueous medium at room temperature

Autor: Harald Gröger, Sonja Borchert, Edyta Burda, Werner Hummel, Jürgen Schatz

Publikováno v: Journal of Molecular Catalysis B: Enzymatic. 84:89-93

We report the combination of a palladium-catalyzed Suzuki cross-coupling reaction with an enzymatic reduction in a one-pot process in aqueous medium, in which both reaction steps are conducted at room temperature. By using a water-soluble palladium c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75232a3b45a2fbe1debb73b71aa66306
https://doi.org/10.1016/j.molcatb.2012.03.006

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Recombinant Î4,5-Steroid 5âÎ²-Reductases as Biocatalysts for the Reduction of Activated Cï£¾C-Double Bonds in Monocyclic and Acyclic Molecules

Autor: Edyta Burda, Wolfgang Kreis, Frieder Müller-Uri, Marina Kraußer, Werner Hummel, Gabriele Fischer, Harald Gröger

Publikováno v: Advanced Synthesis & Catalysis. 351:2787-2790

It was found that Delta(4,5)-steroid 5 beta-reductases are capable of reducing also small molecules bearing an activated C=C double bond such as monocyclic enones and acyclic enoate esters. As preferred Delta(4,5)-steroid 5 beta-reductase (5 beta-StR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f760891e336c098f1a6d7935f596ed
https://doi.org/10.1002/adsc.200900024

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ChemInform Abstract: Highly Enantioselective Reduction of α-Methylated Nitroalkenes

Autor: Till Winkler, Tobias Huber, Harald Groeger, Werner Hummel, Carolin Giese, Tina Ress, Edyta Burda, Xenia Kostrov

Publikováno v: ChemInform. 45

An enzymatic reduction reaction of different substituted nitroalkenes to give chiral nitroalkanes with enantiomeric excess up to 95% e.e.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b701df28aa2fb70b582ecd1284e507cd
https://doi.org/10.1002/chin.201403065

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Catalytic activation of pre-substrates via dynamic Fragment assembly on Protein templates

Autor: Jörg Rademann, Edyta Burda

Sensitive detection of small molecule fragments binding to defined sites of biomacromolecules is still a considerable challenge. Here we demonstrate that protein-binding fragments are able to induce enzymatic reactions on the protein surface via dyna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6255cb95238e99ccb33bea837b6514d4
http://www.nature.com/ncomms/2014/141118/ncomms6170/abs/ncomms6170.html

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