Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Edyta Łukowska-Chojnacka"'
Publikováno v:
Nutrients, Vol 16, Iss 2, p 252 (2024)
Background: Older adults are prone to vitamin D3 (VD3) deficiency, which may impair their health. A high dose of VD3 (HDVD3 = 100,000 IU) could improve their 25-hydroxyvitamin D3 [25(OH)D] level and health outcomes. However, evidence for such a benef
Externí odkaz:
https://doaj.org/article/3832585968a04f59a6035acd7f2b598d
Autor:
Anna Kowalkowska, Konrad Chojnacki, Maciej Multan, Jan K. Maurin, Edyta Łukowska-Chojnacka, Patrycja Wińska
Publikováno v:
Molecules, Vol 27, Iss 14, p 4349 (2022)
Antifungal N-phenacyl derivatives of 4,6- and 5,6-dibromobenzimidazoles are interesting substrates in the synthesis of new antimycotics. Unfortunately, their application is limited by the low synthesis yields and time-consuming separation procedure.
Externí odkaz:
https://doaj.org/article/7a225026206843349f8adc4a475a4026
Autor:
Monika Staniszewska, Łukasz Kuryk, Aleksander Gryciuk, Joanna Kawalec, Marta Rogalska, Joanna Baran, Edyta Łukowska-Chojnacka, Anna Kowalkowska
Publikováno v:
Molecules, Vol 26, Iss 16, p 5008 (2021)
A newly synthetized series of N-phenacyl derivatives of 2-mercaptobenzoxazole, including analogues of 5-bromo- and 5,7-dibromobenzoxazole, were screened against Candida strains and the action mechanism was evaluated. 2-(1,3-benzoxazol-2-ylsulfanyl)-1
Externí odkaz:
https://doaj.org/article/055cc714eabd4dbe9be9d0b5e25acadc
Publikováno v:
Fluid Phase Equilibria. 479:52-62
The examination of physicochemical properties of selected protein kinase CK2 inhibitors: 4,5,6,7-tetrabromo-1H-benzotriazole (TBBt), 4,5,6,7-tetrabromo-1H-benzimidazole (TBBi) and 4,5,6,7-tetrabromo-2-methyl-1H-benzimidazole (2-Me-TBBi) was performed
Autor:
Patrycja Wińska, Katarzyna Skierka, Joanna Cieśla, Edyta Łukowska-Chojnacka, Maria Bretner, Mirosława Koronkiewicz
Publikováno v:
Anticancer Research. 38:4617-4627
Background/aim Protein kinase CK2 was recently identified as a promising therapeutic target for combination therapy. Our study aims to investigate the anticancer effect of a simultaneous inhibition of thymidylate synthase (TS) and CK2 in MCF-7 breast
Autor:
Małgorzata Bondaryk, Monika Staniszewska, Jolanta Mierzejewska, Małgorzata Milner-Krawczyk, Edyta Łukowska-Chojnacka
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:6058-6065
With the appearance of the antifungal resistance, novel antifungal agents need to be identified. In this context new 2,5-disubstituted tetrazole derivatives containing benzothiazole, benzoxazole or phenylsulfonyl moiety were synthesized by N-alkylati
Publikováno v:
Monatshefte Fur Chemie
A series of new benzimidazole and benzotriazole derivatives containing a tetrazole moiety was synthesized by N-alkylation of 5-aryltetrazole with 4,5,6,7-tetrabromo-1-(3-chloropropyl)-1H-benzimidazole and 4,5,6,7-tetrabromo-2-(3-chloropropyl)-2H-benz
Autor:
Jan K. Maurin, Monika Staniszewska, Maria Bretner, Małgorzata Bondaryk, Edyta Łukowska-Chojnacka
Publikováno v:
Chirality. 28:347-354
A series of new N-substituted benzimidazole derivatives was synthesized and their antifungal activity against Candida albicans was evaluated. The chemical step included synthesis of appropriate ketones containing benzimidazole ring, reduction of keto
Autor:
Edyta Łukowska-Chojnacka, Anna Kowalkowska, Małgorzata Gizińska, Monika Staniszewska, Mirosława Koronkiewicz
Publikováno v:
European journal of medicinal chemistry. 164
The increase of opportunistic fungal infections raises the need for design and synthesis of new antifungal agents. Taking into account that tetrazole derivatives exhibit antifungal activity, and some of them are in the phase of clinical trials, new t
Autor:
Karsten Niefind, K. Chojnacki, Christine Tölzer, Monika Wielechowska, Maria Bretner, Edyta Łukowska-Chojnacka, Patrycja Wińska
Publikováno v:
Bioorganic chemistry. 80
The new aminoalkyl-substituted derivatives of known CK2 inhibitors 4,5,6,7-tetrabromo-1H-benzimidazole (TBBi) and 4,5,6,7-tetrabromo-1H-benzotriazole (TBBt) were synthesized, and their influence on the activity of recombinant human CK2 α, CK2 holoen