Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Edwina McGlinn"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The Nuclear Receptor (NR) family of transcriptional regulators possess the ability to sense signalling molecules and directly couple that to a transcriptional response. While this large class of proteins are united by sequence and structural homology
Externí odkaz:
https://doaj.org/article/02cbeb0ffe6b436b8bb8785b11497e7d
Autor:
Andres Tapia del Fierro, Bianca den Hamer, Natalia Benetti, Natasha Jansz, Kelan Chen, Tamara Beck, Hannah Vanyai, Alexandra D. Gurzau, Lucia Daxinger, Shifeng Xue, Thanh Thao Nguyen Ly, Iromi Wanigasuriya, Megan Iminitoff, Kelsey Breslin, Harald Oey, Yvonne D. Krom, Dinja van der Hoorn, Linde F. Bouwman, Timothy M. Johanson, Matthew E. Ritchie, Quentin A. Gouil, Bruno Reversade, Fabrice Prin, Timothy Mohun, Silvère M. van der Maarel, Edwina McGlinn, James M. Murphy, Andrew Keniry, Jessica C. de Greef, Marnie E. Blewitt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The interplay between 3D chromatin architecture and gene silencing is incompletely understood. Here, we report a novel point mutation in the non-canonical SMC protein SMCHD1 that enhances its silencing capacity at endogenous developmental ta
Externí odkaz:
https://doaj.org/article/4b268abe87144921872eecf80d018c13
Autor:
Yi-Cheng Chang, Jan Manent, Jan Schroeder, Siew Fen Lisa Wong, Gabriel M. Hauswirth, Natalia A. Shylo, Emma L. Moore, Annita Achilleos, Victoria Garside, Jose M. Polo, Paul Trainor, Edwina McGlinn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The authors identify Nuclear receptor subfamily 6 group A member 1 (Nr6a1) as a master regulator of elongation, segmentation, patterning and lineage allocation specifically within the trunk region of the mouse, acting downstream of the major signals
Externí odkaz:
https://doaj.org/article/117f96f9c40b48e6a5318dfb51a9856a
Autor:
Natalia Benetti, Quentin Gouil, Andres Tapia del Fierro, Tamara Beck, Kelsey Breslin, Andrew Keniry, Edwina McGlinn, Marnie E. Blewitt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Parents transmit both genetic and epigenetic information to their offspring, with maternal effect genes being critical regulators of the offspring epigenome. Here they show that maternally deposited SMCHD1 has long-lasting effects on Hox gene express
Externí odkaz:
https://doaj.org/article/f3dd1a6eccaf4f698759ff576571bf98
Autor:
Gabriel M. Hauswirth, Victoria C. Garside, Lisa S. F. Wong, Heidi Bildsoe, Jan Manent, Yi-Cheng Chang, Christian M. Nefzger, Jaber Firas, Joseph Chen, Fernando J. Rossello, Jose M. Polo, Edwina McGlinn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Vertebral column length and shape exhibits remarkable robustness within a species but diversity across species. Here the authors reveal the molecular logic constraining vertebral number in mouse and a novel role for posterior Hox genes in this contex
Externí odkaz:
https://doaj.org/article/2da6dd6edf0246ddb0e84b2cc0ddcf45
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/477175f1556d4d6bbb5051b7855b94f9
Autor:
Chung‐Jung Li, Ee Shan Liau, Yi‐Han Lee, Yang‐Zhe Huang, Ziyi Liu, Andrew Willems, Victoria Garside, Edwina McGlinn, Jun‐An Chen, Tian Hong
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 4, Pp n/a-n/a (2021)
Abstract Positive feedback driven by transcriptional regulation has long been considered a key mechanism underlying cell lineage segregation during embryogenesis. Using the developing spinal cord as a paradigm, we found that canonical, transcription
Externí odkaz:
https://doaj.org/article/41afa7d3db8c48f1941a4a3e0a07bcb4
Autor:
Eamon Coughlan, Victoria C. Garside, Siew Fen Lisa Wong, Huazheng Liang, Dominik Kraus, Kajari Karmakar, Upasana Maheshwari, Filippo M. Rijli, James Bourne, Edwina McGlinn
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2408-2421.e4 (2019)
Summary: Coordinated movement requires the integration of many sensory inputs including proprioception, the sense of relative body position and force associated with movement. Proprioceptive information is relayed to the cerebellum via spinocerebella
Externí odkaz:
https://doaj.org/article/217fc940a6ea405fbe77749caa8e9150
Autor:
Liam Town, Edwina McGlinn, Tara-Lynne Davidson, Catherine M Browne, Kallayanee Chawengsaksophak, Peter Koopman, Joy M Richman, Carol Wicking
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25228 (2011)
The Tmem26 gene encodes a novel protein that we have previously shown to be regulated by hedgehog signalling in the mouse limb. We now report that Tmem26 expression is spatially and temporally restricted in other regions of the mouse embryo, most not
Externí odkaz:
https://doaj.org/article/51b34c37d2704496959e2675818e8d07
Autor:
Yi-Cheng Chang, Siew Fen Lisa Wong, Jan Schroeder, Gabriel M. Hauswirth, Natalia A Shylo, Emma L Moore, Annita Achilleos, Victoria Garside, Jose M. Polo, Jan Manent, Paul Trainor, Edwina McGlinn
The vertebrate main-body axis is laid down during embryonic stages in an anterior-to-posterior (head-to-tail) direction, driven and supplied by posteriorly located progenitors. For the vertebral column, the process of axial progenitor cell expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bca7cab8477591c3f21d4cea0bde781
https://doi.org/10.1101/2022.03.21.485239
https://doi.org/10.1101/2022.03.21.485239