Inter-Laboratory Evaluation of a Next-Generation Sequencing Panel for Acute Myeloid Leukemia

Autor: Edwina Dobbin, Stephen E. Langabeer, Sproul Am, Ken I. Mills, Karl Haslam, Mark Catherwood

Publikováno v: Haslam, K, Catherwood, M A, Dobbin, E, Sproul, A, Langabeer, S E & Mills, K I 2016, ' Inter-Laboratory Evaluation of a Next-Generation Sequencing Panel for Acute Myeloid Leukemia ', Molecular Diagnosis & Therapy, vol. 20, no. 5, pp. 457-461 . https://doi.org/10.1007/s40291-016-0222-3

INTRODUCTION: Acute myeloid leukemia (AML) is a heterogeneous clonal disorder often associated with dismal overall survival. The clinical diversity of AML is reflected in the range of recurrent somatic mutations in several genes, many of which have a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a5b586a28be482ef3a147bea0f06d0
https://pure.qub.ac.uk/en/publications/interlaboratory-evaluation-of-a-nextgeneration-sequencing-panel-for-acute-myeloid-leukemia(5d8c4aff-f7bd-458d-8cbc-5d50050d86e3).html

ZAP-70 mRNA quantification in B-cell chronic lymphocytic leukaemia

Autor: Edwina Dobbin, Roberta Niblock, Treen C. M. Morris, H. Denis Alexander, Mark Catherwood, Christine Matthews

Publikováno v: European Journal of Haematology. 76:294-298

Objective: The mutational status of the immunoglobulin (Ig) V H gene in B-cell chronic lymphocytic leukaemia (B-CLL) identifies two subgroups of patients with significantly different outcomes. We investigated the association of ZAP-70 expression with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86f473db58854a5128fbdfea5d66077
https://doi.org/10.1111/j.1600-0609.2005.00619.x

Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL

Autor: Mike Leach, Emilio Cosimo, C Clarke, Helen Wheadon, Alison McCaig, Alison M. Michie, Odette Middleton, Edwina Dobbin, A M Brant

Publikováno v: Leukemia. 29(1)

Monoclonal antibodies (MAbs) form a central part of chronic lymphocytic leukaemia (CLL) treatment. We therefore evaluated whether complement defects in CLL patients reduced the induction of complement-dependent cytotoxicity (CDC) by using anti-CD20 M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5478e008bcb5fefcf15346c02e64e73
https://pubmed.ncbi.nlm.nih.gov/24787488

Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis

Autor: Edwina Dobbin, Pamela M. Corrigan, Robin Freeburn, Helen Wheadon

Publikováno v: Stem cells and development. 18(5)

Wnt signaling plays several roles in hematopoiesis, promoting hemopoietic stem cell (HSC) self-renewal, providing proliferative signals for immature progenitors and regulating lineage commitment. To ascertain which Wnt proteins and receptors are impo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5104da50a830d9777cbd7e844965a7
https://pubmed.ncbi.nlm.nih.gov/18800919

Canonical Wnt Signaling Promotes Early Hematopoietic Progenitor Formation and Erythroid Specification during Embryonic Stem Cell Differentiation

Autor: Robin Freeburn, Edwina Dobbin, Anuradha Tarafdar, Pamela M. Corrigan, Helen Wheadon

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 11, p e81030 (2013)

The generation of hematopoietic stem cells (HSCs) during development is a complex process linked to morphogenic\ud signals. Understanding this process is important for regenerative medicine applications that require in vitro production of HSC. In thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d10af4a8c9ac8a11b3f660d97dd2d0
https://doi.org/10.1371/journal.pone.0081030