Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Edwin W, Lai"'
Autor:
Juanjuan Li, Bradley M. Downs, Leslie M. Cope, Mary Jo Fackler, Xiuyun Zhang, Chuan-gui Song, Christopher VandenBussche, Kejing Zhang, Yong Han, Yufei Liu, Suzana Tulac, Neesha Venkatesan, Timothy de Guzman, Chuang Chen, Edwin W. Lai, Jingping Yuan, Saraswati Sukumar
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Preoperative staging of suspicious axillary lymph nodes (ALNs) allows patients to be triaged to ALN dissection or to sentinel lymph node biopsy (SLNB). Ultrasound-guided fine needle aspiration (FNA) and cytology of ALN is moderately sensitiv
Externí odkaz:
https://doaj.org/article/86a221899d2a40bf8a198d08bfddb605
Autor:
Swati Gupta, Leena McCann, Yvonne G. Y. Chan, Edwin W. Lai, Wei Wei, Pok Fai Wong, James W. Smithy, Jodi Weidler, Brian Rhees, Michael Bates, Harriet M. Kluger, David L. Rimm
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Background In melanoma, there is no companion diagnostic test to predict response to programmed cell death 1 (PD-1) axis immune checkpoint inhibitor (ICI) therapy. In the adjuvant setting, only one in five patients may benefit from ICI, so a
Externí odkaz:
https://doaj.org/article/753f2d78f9e54da6aa048a1cde53fbc9
Autor:
Saraswati Sukumar, Edwin W. Lai, Michael Bates, Vered Stearns, Antonio C. Wolff, Christopher B. Umbricht, Kala Visvanathan, Morgan E. Buckley, Jeffrey Reynolds, Rita Denbow, Jennifer Lehman, Wanjun Ding, Abdul Hussain Vali, Bradley M. Downs, Leslie M. Cope, Claudia Mercado-Rodriguez, Timothy N. de Guzman, Adam J. Aslam, Neesha Venkatesan, Suzana Tulac, Mary Jo Fackler
The table provides a step by step guide to calculate methylation in each gene followed by cumulative methylation using the algorithm derived in this paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0f0db05a9f6502f4054894de57a4c7
https://doi.org/10.1158/2767-9764.22544640.v1
https://doi.org/10.1158/2767-9764.22544640.v1
Autor:
Saraswati Sukumar, Edwin W. Lai, Michael Bates, Vered Stearns, Antonio C. Wolff, Christopher B. Umbricht, Kala Visvanathan, Morgan E. Buckley, Jeffrey Reynolds, Rita Denbow, Jennifer Lehman, Wanjun Ding, Abdul Hussain Vali, Bradley M. Downs, Leslie M. Cope, Claudia Mercado-Rodriguez, Timothy N. de Guzman, Adam J. Aslam, Neesha Venkatesan, Suzana Tulac, Mary Jo Fackler
Figure shows the perfomance of LBx-BCM in the training set samples. A histogram shows cumulative methylation for each sample, and a box plot shows significnt difference of methylation in serum of metastatic breast cancer patients compared to normal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fbbfde44501db0c5e89a259d2120e9
https://doi.org/10.1158/2767-9764.22544652
https://doi.org/10.1158/2767-9764.22544652
Autor:
Saraswati Sukumar, Edwin W. Lai, Michael Bates, Vered Stearns, Antonio C. Wolff, Christopher B. Umbricht, Kala Visvanathan, Morgan E. Buckley, Jeffrey Reynolds, Rita Denbow, Jennifer Lehman, Wanjun Ding, Abdul Hussain Vali, Bradley M. Downs, Leslie M. Cope, Claudia Mercado-Rodriguez, Timothy N. de Guzman, Adam J. Aslam, Neesha Venkatesan, Suzana Tulac, Mary Jo Fackler
Current molecular liquid biopsy assays to detect recurrence or monitor response to treatment require sophisticated technology, highly trained personnel, and a turnaround time of weeks. We describe the development and technical validation of an automa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149cae505222e663985c162ddc1acce1
https://doi.org/10.1158/2767-9764.c.6550710
https://doi.org/10.1158/2767-9764.c.6550710
Autor:
Mary Jo Fackler, Suzana Tulac, Neesha Venkatesan, Adam J. Aslam, Timothy N. de Guzman, Claudia Mercado-Rodriguez, Leslie M. Cope, Bradley M. Downs, Abdul Hussain Vali, Wanjun Ding, Jennifer Lehman, Rita Denbow, Jeffrey Reynolds, Morgan E. Buckley, Kala Visvanathan, Christopher B. Umbricht, Antonio C. Wolff, Vered Stearns, Michael Bates, Edwin W. Lai, Saraswati Sukumar
Publikováno v:
Cancer Res Commun
Current molecular liquid biopsy assays to detect recurrence or monitor response to treatment require sophisticated technology, highly trained personnel, and a turnaround time of weeks. We describe the development and technical validation of an automa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caa819910e901535bdf719e430309e9
https://doi.org/10.1158/2767-9764.crc-22-0133
https://doi.org/10.1158/2767-9764.crc-22-0133
Autor:
Johannes A. Hainfellner, Martin Filipits, Sabine Spiegl-Kreinecker, Anna S. Berghoff, Christopher L. Corless, Andrew Kohlway, Michael Bates, Kriszten Kocmond, Edwin W. Lai, Matthias Preusser, Jodi Weidler
Publikováno v:
Anticancer Research. 40:6229-6236
Background/aim To compare the GeneXpert® O6-methylguanine DNA methyltransferase (MGMT) methylation prototype (GX MGMT) assay with pyrosequencing in glioblastomas. Materials and methods The MGMT methylation status was retrospectively assessed in form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592a024ee53967f1875ed38afcf168ce
https://doi.org/10.21873/anticanres.14643
https://doi.org/10.21873/anticanres.14643
Autor:
Neesha Venkatesan, Jingping Yuan, Suzana Tulac, Chuang Chen, Mary Jo Fackler, Bradley M. Downs, Chuan gui Song, Juanjuan Li, Yufei Liu, Kejing Zhang, Timothy de Guzman, Leslie Cope, Xiuyun Zhang, Christopher J. VandenBussche, Saraswati Sukumar, Yong Han, Edwin W. Lai
Publikováno v:
NPJ Breast Cancer
npj Breast Cancer, Vol 7, Iss 1, Pp 1-9 (2021)
npj Breast Cancer, Vol 7, Iss 1, Pp 1-9 (2021)
Preoperative staging of suspicious axillary lymph nodes (ALNs) allows patients to be triaged to ALN dissection or to sentinel lymph node biopsy (SLNB). Ultrasound-guided fine needle aspiration (FNA) and cytology of ALN is moderately sensitive but its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9f52cfecaa3fbd896bee1e21346cb1
https://doi.org/10.1038/s41523-021-00298-6
https://doi.org/10.1038/s41523-021-00298-6
Autor:
Suzana Tulac, Bradley M. Downs, Saraswati Sukumar, Eunice van den Berg, Leslie Cope, Susan C. Harvey, Claudia Mercado-Rodriguez, Christopher B. Umbricht, Juanjuan Li, Mary Jo Fackler, Monica Rizzo, Edwin W. Lai, Rupali Sood, Edward Gabrielson, Marina Mosunjac, Michael Bates, Andrea L. Richardson, Kriszten Kocmond, Jing Ping Yuan, Brian Rhees, Timothy de Guzman, Antonio C. Wolff, Fernando Schmitt, Ashley Cimino-Mathews, Chuang Chen, Gary Tse, Danielle Meir-Levi, Kala Visvanathan, Syed Z. Ali
Publikováno v:
Clin Cancer Res
Purpose:An unmet need in low-resource countries is an automated breast cancer detection assay to prioritize women who should undergo core breast biopsy and pathologic review. Therefore, we sought to identify and validate a panel of methylated DNA mar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a72fa2be2f8acf1452f07e5629a312d
https://doi.org/10.1158/1078-0432.ccr-18-3277
https://doi.org/10.1158/1078-0432.ccr-18-3277
Autor:
N Wu, David L. Rimm, Veronique Neumeister, Brad Wasserman, Wendy Wong, Edwin W. Lai, VC Chu, Kenneth E. Ho, Jodi Weidler, Daniel E. Carvajal-Hausdorf, Michael Bates
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Background Historically, mRNA measurements have been tested on several commercially available platforms, but none have gained broad acceptance for assessment of HER2. An mRNA measurement, as a continuous value, has the potential for use in adjudicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d384a288cb48d718e5efd8d582d735d
https://doi.org/10.1038/labinvest.2017.93
https://doi.org/10.1038/labinvest.2017.93