Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Edwin T. Parlevliet"'
Autor:
Sander Kooijman, Mariëtte R. Boon, Edwin T. Parlevliet, Janine J. Geerling, Vera van de Pol, Johannes A. Romijn, Louis M. Havekes, Illiana Meurs, Patrick C.N. Rensen
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2022-2032 (2014)
The melanocortin system is an important regulator of energy balance, and melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity. We investigated whether the relationship between melanocortin system activity and energy
Externí odkaz:
https://doaj.org/article/1b0ca6cb4294435fa64980491e7d577b
Autor:
Janine J. Geerling, Mariëtte R. Boon, Sander Kooijman, Edwin T. Parlevliet, Louis M. Havekes, Johannes A. Romijn, Illiana M. Meurs, Patrick C.N. Rensen
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 2, Pp 180-189 (2014)
Important players in triglyceride (TG) metabolism include the liver (production), white adipose tissue (WAT) (storage), heart and skeletal muscle (combustion to generate ATP), and brown adipose tissue (BAT) (combustion toward heat), the collective ac
Externí odkaz:
https://doaj.org/article/22c9af50d84f4e3fa91da41d2927932a
Autor:
Claudia P. Coomans, Janine J. Geerling, Bruno Guigas, Anita M. van den Hoek, Edwin T. Parlevliet, D. Margriet Ouwens, Hanno Pijl, Peter J. Voshol, Patrick C.N. Rensen, Louis M. Havekes, Johannes A. Romijn
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 9, Pp 1712-1722 (2011)
Insulin signaling in the central nervous system (CNS) is required for the inhibitory effect of insulin on glucose production. Our aim was to determine whether the CNS is also involved in the stimulatory effect of circulating insulin on the tissue-spe
Externí odkaz:
https://doaj.org/article/e28774ae54384d0baefe6731789094a9
Autor:
Rashmi B. Prasad, Torben Hansen, Patrick C.N. Rensen, Sune Skeldal, Dorthe Maria Vittrup, Karen M. Pedersen, Olof Asplund, Christian Bjerggaard Vaegter, Anette Marianne Prior Gjessing, Andreas N. Madsen, Karen Marie Juul Sørensen, Mads Kjolby, Maarten Rotman, Dovile Januliene, Olav M. Andersen, Guido Hermey, Edwin T. Parlevliet, Birgitte Holst, Arne Moller, Gangadaar Thotakura, Ernst-Martin Füchtbauer, Søren Thirup, Peder Madsen, Niels Wellner, Peter Breining, Arulmani Manavalan
Type II diabetes mellitus (T2DM) has reached endemic levels and comprises a substantial burden to the patient and the society. Along with lifestyle factors, a number of genetic loci predisposing to T2DM have been suggested including SORCS1 that encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbdadf328d061149c37f06c00ea13f49
https://doi.org/10.1101/2020.11.10.376178
https://doi.org/10.1101/2020.11.10.376178
Autor:
Edwin T Parlevliet, Yanan Wang, Janine J Geerling, Janny P Schröder-Van der Elst, Kristen Picha, Karyn O'Neil, Vedrana Stojanovic-Susulic, Tatiana Ort, Louis M Havekes, Johannes A Romijn, Hanno Pijl, Patrick C N Rensen
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49152 (2012)
ObjectiveIn addition to improve glucose intolerance, recent studies suggest that glucagon-like peptide-1 (GLP-1) receptor agonism also decreases triglyceride (TG) levels. The aim of this study was to evaluate the effect of GLP-1 receptor agonism on v
Externí odkaz:
https://doaj.org/article/22f65b1129434deb817148c89ddabf95
Autor:
Cindy P. A. A. van Roomen, Ewout Foppen, Mina Mirzaian, Sander Kooijman, Saskia Scheij, Herman S. Overkleeft, Chun-Xia Yi, Roelof Ottenhoff, Marco van Eijk, Clarita Mergen, Patrick C.N. Rensen, Yanan Wang, Kirstin Jansen, Daniela Herrera Moro Chao, Matthias H. Tschöp, Johannes M. F. G. Aerts, Edwin T. Parlevliet, Marri Verhoek, Dawei Wang, André Marques, Rolf G. Boot, Andries Kalsbeek, Randy J. Seeley
Publikováno v:
Diabetes, 68(12), 2223-2234. AMER DIABETES ASSOC
Diabetes 68, 2223-2234 (2019)
Diabetes, 68(12), 2223-2234
Diabetes, 68, 2223-2234. American Diabetes Association Inc.
Diabetes, 68(12), 2223-2234. American Diabetes Association Inc.
Diabetes 68, 2223-2234 (2019)
Diabetes, 68(12), 2223-2234
Diabetes, 68, 2223-2234. American Diabetes Association Inc.
Diabetes, 68(12), 2223-2234. American Diabetes Association Inc.
Obesity is taking on worldwide epidemic proportions, yet effective pharmacological agents with long-term efficacy remain unavailable. Previously, we designed the iminosugar N-adamantine-methyloxypentyl-deoxynojirimycin (AMP-DNM), which potently impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6eeea7db358776e32d871b6706e3ba6
https://hdl.handle.net/1887/3199006
https://hdl.handle.net/1887/3199006
Autor:
Mariëtte R. Boon, I Meurs, Johannes A. Romijn, Janine J. Geerling, Patrick C.N. Rensen, Louis M. Havekes, Sander Kooijman, Edwin T. Parlevliet
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 2, Pp 180-189 (2014)
Journal of Lipid Research, 2, 55, 180-189
Journal of Lipid Research, 55(2), 180-189
Journal of Lipid Research, 2, 55, 180-189
Journal of Lipid Research, 55(2), 180-189
Important players in triglyceride (TG) metabolism include the liver (production), white adipose tissue (WAT) (storage), heart and skeletal muscle (combustion to generate ATP), and brown adipose tissue (BAT) (combustion toward heat), the collective ac
Autor:
Patrick C.N. Rensen, Janine J. Geerling, Ronit Shiri-Sverdlov, K. Willems van Dijk, Johannes A. Romijn, S. J. L. van der Tuin, Ilze Bot, L.M. Havekes, A. H. M. Jawad, Edwin T. Parlevliet, S.C.A. de Jager, Yanan Wang, H. Zhang, Veerle Bieghs
Publikováno v:
British Journal of Pharmacology, 171(3), 723-734
British Journal of Pharmacology, 171(3), 723-734. Wiley
British journal of pharmacology, 171(3), 723-734. Wiley-Blackwell
British Journal of Pharmacology, 3, 171, 723-734
British Journal of Pharmacology, 171(3), 723-734. Wiley
British journal of pharmacology, 171(3), 723-734. Wiley-Blackwell
British Journal of Pharmacology, 3, 171, 723-734
Background and Purpose The aetiology of inflammation in the liver and vessel wall, leading to non-alcoholic steatohepatitis (NASH) and atherosclerosis, respectively, shares common mechanisms including macrophage infiltration. To treat both disorders
Publikováno v:
Frontiers of hormone research. 42:50-58
Insulin sensitivity is determined by direct effects of circulating insulin on metabolically active tissues in combination with indirect effects of circulating insulin, i.e. via the central nervous system. The dose-response effects of insulin differ b
Publikováno v:
American journal of physiology. Endocrinology and metabolism, 299(2), E318-E324. American Physiological Society
Glucagon-like peptide-1 (GLP-1) improves insulin sensitivity in humans and rodents. It is currently unknown to what extent the (metabolic) effects of GLP-1 treatment are mediated by central GLP-1 receptors. We studied the impact of central GLP-1 rece