Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Edwin S. Monuki"'
Autor:
Paolo Reho, Sara Saez-Atienzar, Paola Ruffo, Sultana Solaiman, Zalak Shah, Ruth Chia, Karri Kaivola, Bryan J. Traynor, Bension S. Tilley, Steve M. Gentleman, Angela K. Hodges, Dag Aarsland, Edwin S. Monuki, Kathy L. Newell, Randy Woltjer, Marilyn S. Albert, Ted M. Dawson, Liana S. Rosenthal, Juan C. Troncoso, Olga Pletnikova, Geidy E. Serrano, Thomas G. Beach, Hariharan P. Easwaran, Sonja W. Scholz
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population. We performed genome-wide DNA methylation mapping of cerebellar tissue from pathologically confirmed DLB cases and controls to study the epigenetic profil
Externí odkaz:
https://doaj.org/article/1f5a47a3a95d4835830f83e30874d417
Autor:
Daniel R. Wong, Shino D. Magaki, Harry V. Vinters, William H. Yong, Edwin S. Monuki, Christopher K. Williams, Alessandra C. Martini, Charles DeCarli, Chris Khacherian, John P. Graff, Brittany N. Dugger, Michael J. Keiser
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Precise, scalable, and quantitative evaluation of whole slide images is crucial in neuropathology. We release a deep learning model for rapid object detection and precise information on the identification, locality, and counts of cored plaqu
Externí odkaz:
https://doaj.org/article/c3d3f3daf1b44aed967015946cc7eb2d
Autor:
Jason K. Karimy, Jessie C. Newville, Cameron Sadegh, Jill A. Morris, Edwin S. Monuki, David D. Limbrick, James P. McAllister II, Jenna E. Koschnitzky, Maria K. Lehtinen, Lauren L. Jantzie
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4 and 5, 2019 at Washington University in St. Louis. The workshop brought together a diverse gr
Externí odkaz:
https://doaj.org/article/539642b289504d639e5e88ca53cd606e
Autor:
Shruti K. Gohil, Kathleen A. Quan, Keith M. Madey, Suzanne King-Adelsohn, Tom Tjoa, Delia Tifrea, Bridgit O. Crews, Edwin S. Monuki, Saahir Khan, Sebastian D. Schubl, Cassiana E. Bittencourt, Neil Detweiler, Wayne Chang, Lynn Willis, Usme Khusbu, Antonella Saturno, Sherif A. Rezk, Cesar Figueroa, Aarti Jain, Rafael Assis, Philip Felgner, Robert Edwards, Lanny Hsieh, Donald Forthal, William C. Wilson, Michael J. Stamos, Susan S. Huang
Publikováno v:
Antimicrobial Resistance and Infection Control, Vol 10, Iss 1, Pp 1-10 (2021)
Abstract Background Early evaluations of healthcare professional (HCP) COVID-19 risk occurred during insufficient personal protective equipment and disproportionate testing, contributing to perceptions of high patient-care related HCP risk. We evalua
Externí odkaz:
https://doaj.org/article/1f157951ed82497887ebb7727d5bcb75
Autor:
Yan Guo, Alison.A. Chomiak, Ye Hong, Clara C. Lowe, Caroline A. Kopsidas, Wen-Ching Chan, Jorge Andrade, Hongna Pan, Xiaoming Zhou, Edwin S. Monuki, Yuanyi Feng
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104519- (2022)
Summary: Aging is an intricate process characterized by multiple hallmarks including stem cell exhaustion, genome instability, epigenome alteration, impaired proteostasis, and cellular senescence. Whereas each of these traits is detrimental at the ce
Externí odkaz:
https://doaj.org/article/600df9637a5a4198b6f7f28e33a479b5
Autor:
Andrew R. Yale, Jamison L. Nourse, Kayla R. Lee, Syed N. Ahmed, Janahan Arulmoli, Alan Y.L. Jiang, Lisa P. McDonnell, Giovanni A. Botten, Abraham P. Lee, Edwin S. Monuki, Michael Demetriou, Lisa A. Flanagan
Publikováno v:
Stem Cell Reports, Vol 11, Iss 4, Pp 869-882 (2018)
Summary: Understanding the cellular properties controlling neural stem and progenitor cell (NSPC) fate choice will improve their therapeutic potential. The electrophysiological measure whole-cell membrane capacitance reflects fate bias in the neural
Externí odkaz:
https://doaj.org/article/9fafdf8678d442e59a451081bcb91b7b
Autor:
Brett A. Johnson, Margaret Coutts, Hillary M. Vo, Xinya Hao, Nida Fatima, Maria J. Rivera, Robert J. Sims, Michael J. Neel, Young-Jin Kang, Edwin S. Monuki
Publikováno v:
Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-18 (2018)
Abstract Background Choroid plexus epithelial cells express high levels of transthyretin, produce cerebrospinal fluid and many of its proteins, and make up the blood-cerebrospinal fluid barrier. Choroid plexus epithelial cells are vital to brain heal
Externí odkaz:
https://doaj.org/article/551c14112ec94f029772f4f8b11b9ce2
Autor:
Katja M. Piltti, Gabriella M. Funes, Sabrina N. Avakian, Ara A. Salibian, Kevin I. Huang, Krystal Carta, Noriko Kamei, Lisa A. Flanagan, Edwin S. Monuki, Nobuko Uchida, Brian J. Cummings, Aileen J. Anderson
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1534-1548 (2017)
Multipotent human central nervous system-derived neural stem cells transplanted at doses ranging from 10,000 (low) to 500,000 (very high) cells differentiated predominantly into the oligodendroglial lineage. However, while the number of engrafted cel
Externí odkaz:
https://doaj.org/article/9fa2f646accf495fbb127312df542fdb
Autor:
Samuel E. Marsh, Stephen T. Yeung, Maria Torres, Lydia Lau, Joy L. Davis, Edwin S. Monuki, Wayne W. Poon, Mathew Blurton-Jones
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 235-248 (2017)
Transplantation of neural stem cells (NSCs) can improve cognition in animal models of Alzheimer's disease (AD). However, AD is a protracted disorder, and prior studies have examined only short-term effects. We therefore used an immune-deficient model
Externí odkaz:
https://doaj.org/article/78deaca7b19a4465b30ac39383bbc688
Autor:
Momoko Watanabe, Ernest S. Fung, Felicia B. Chan, Jessica S. Wong, Margaret Coutts, Edwin S. Monuki
Publikováno v:
Biology Open, Vol 5, Iss 12, Pp 1834-1843 (2016)
The concept of a morphogen – a molecule that specifies two or more cell fates in a concentration-dependent manner – is paradigmatic in developmental biology. Much remains unknown, however, about the existence of morphogens in the developing verte
Externí odkaz:
https://doaj.org/article/a395dd8fb5084cc28796eec4e6d94510