Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Edwin S, Levitan"'
Autor:
Dinara Bulgari, Samantha L. Cavolo, Brigitte F. Schmidt, Katherine Buchan, Marcel P. Bruchez, David L. Deitcher, Edwin S. Levitan
Neuronal dense-core vesicles (DCVs) contain neuropeptides and much larger proteins that affect synaptic growth and plasticity. Rather than using full collapse exocytosis that is common in endocrine cells, DCVs at a native intact synapse, theDrosophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97da64bd3ae2687d717cccfea0109243
https://doi.org/10.1101/2022.12.24.521856
https://doi.org/10.1101/2022.12.24.521856
Publikováno v:
Translational Stroke Research
Cerebrovascular disease is the most common life-threatening and debilitating condition that often leads to stroke. The multifunctional calcium/calmodulin-dependent protein kinase II (CaMKII) is a key Ca2+ sensor and an important signaling protein in
Autor:
Allison M Orzel, Richard I. Hume, Miranda C Lum, Lilly E. Reid, Catherine A. Collins, Jade E Varineau, Edwin S. Levitan, John Y. Kuwada, Haoxing Xu, Ari Leflein, Xiaoli Zhang, Jeremy W. Linsley, Drew A Berkhoudt, I-Uen Hsu
Publikováno v:
Proc Natl Acad Sci U S A
Significance Many neurons release neuropeptides as well as classical neurotransmitters. Neuropeptides often regulate neural circuits controlling behaviors such as emotional behaviors. However, how neuropeptide release is regulated is not well-underst
Autor:
Bartholomew P Roland, Alison M Zeccola, Samantha B Larsen, Christopher G Amrich, Aaron D Talsma, Kimberly A Stuchul, Annie Heroux, Edwin S Levitan, Andrew P VanDemark, Michael J Palladino
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005941 (2016)
Triosephosphate isomerase (TPI) deficiency is a poorly understood disease characterized by hemolytic anemia, cardiomyopathy, neurologic dysfunction, and early death. TPI deficiency is one of a group of diseases known as glycolytic enzymopathies, but
Externí odkaz:
https://doaj.org/article/b75cd7b9bdc3464da04a9f6e4c95a120
Autor:
Seth H. Walters, Edwin S. Levitan
Publikováno v:
Schizophr Bull
Many psychiatric drugs are weak bases that accumulate in and are released from synaptic vesicles, but the functional impact of vesicular drug release is largely unknown. Here, we examine the effect of vesicular release of the anxiolytic antipsychotic
Publikováno v:
Proc Natl Acad Sci U S A
Neuropeptides control rhythmic behaviors, but the timing and location of their release within circuits is unknown. Here imaging in the brain shows that synaptic neuropeptide release by Drosophila clock neurons is diurnal, peaking at times of day that
Publikováno v:
ACS Chem Neurosci
Recent optical observations of dopamine at axon terminals and kinetic modeling of evoked dopamine responses measured by fast scan cyclic voltammetry (FSCV) support local restriction of dopamine diffusion at synaptic release sites. Yet, how this diffu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8776ec62a8c00232f4845e4c057f2c
https://europepmc.org/articles/PMC9668542/
https://europepmc.org/articles/PMC9668542/
Autor:
Melanie F. Landay, Xiao Ying Yin, Edward V. Prochownik, Edwin S. Levitan, Simon C. Watkins, Richard M. Levenson, Daniel L. Farkas, Weiping Han
Publikováno v:
Oncogene. 40:6308-6308
Publikováno v:
European Journal of Cell Biology. 96:402-406
The Huntington’s disease protein Huntingtin (Htt) regulates axonal transport of dense-core vesicles (DCVs) containing neurotrophins and neuropeptides. DCVs travel down axons to reach nerve terminals where they are either captured in synaptic bouton
Publikováno v:
The Journal of Neuroscience. 36:11781-11787
Synaptic neuropeptide and neurotrophin stores are maintained by constitutive bidirectional capture of dense-core vesicles (DCVs) as they circulate in and out of the nerve terminal. Activity increases DCV capture to rapidly replenish synaptic neuropep