Výsledky vyhledávání - "Edwin Roovers"

The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci

Autor: Marius J. Giphart, Edwin Roovers, Arno R. van der Slik, Ferdinand C. Breedveld, Willem Verduyn, René R. P. de Vries, Eric Zanelli, Maria J. Pascual, Javier Martín, Gavin C. Jones, P. Eerligh, Geziena M.Th. Schreuder, Aeilko H. Zwinderman

Publikováno v: Human Immunology. 62:75-84

We have evaluated the possible contribution of genes besides DQ and DR to the association of HLA with rheumatoid arthritis (RA). To this end, we have looked at the allele distributions of six microsatellites, D6S1014, D6S2673, TNFα, MIB, C1-2-5, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37e61a018014c58882943030303fe2b
https://doi.org/10.1016/s0198-8859(00)00227-5

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Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

Autor: H. Timmerman, J Blauw, A. E. Alewijnse, Edwin Roovers, Y Van De Vrede, Rob Leurs, Martine J. Smit, G P Van Nieuw Amerongen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 93, 6802-9807. National Acad Sciences
Smit, M J, Leurs, R, Alewijnse, A E, Blauw, J, van Nieuw Amerongen, G P, van de Vrede, Y, Roovers, E & Timmerman, H 1996, ' Inverse agonism of histamine H2 antagonists accounts for upregulation of spontaneously active histamine H2 receptors. ', Proceedings of the National Academy of Sciences of the United States of America, vol. 93, pp. 6802-9807 . https://doi.org/10.1073/pnas.93.13.6802

Histamine H2 receptors transfected in Chinese hamster ovary (CHO) cells are time- and dose-dependently upregulated upon exposure to the H2 antagonists cimetidine and ranitidine. This effect appears to be H2 receptor-mediated as no change in receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d64b95341187f24799e826bae8a093
https://doi.org/10.1073/pnas.93.13.6802

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The C terminal tail of the histamine H2 receptor contains positive and negative signals important for signal transduction and receptor down-regulation

Autor: Margot W. Beukers, Marcel Hoffmann, Edwin Roovers, Rob Leurs, J. Blauw, Martine J. Smit, H. Timmerman, Edwin H. Jacobs

Publikováno v: Smit, M J, Timmerman, H, Beukers, M W, Roovers, E, Jacobs, E H, Hoffmann, M & Leurs, R 1996, ' The C terminal tail of the histamine H2 receptor contains positive and negative signals important for signal transduction and receptor down-regulation. ', Journal of Neurochemistry, vol. 67, no. 5, pp. 1791-1800 . https://doi.org/10.1046/j.1471-4159.1996.67051791.x
Journal of Neurochemistry, 67(5), 1791-1800. Wiley-Blackwell

To examine the role of the C terminal tail in H 2 receptor regulation, three cDNAs, encoding truncated histamine H 2 receptor mutants (H 2 T295, H 2 T307, and H 2 T341), were constructed and stably transfected in Chinese hamster ovary (CHO) cells. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252c3d5ed0c40e867c727264eb69b1ce
https://doi.org/10.1046/j.1471-4159.1996.67051791.x

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Two distinct pathways for histamine H2 receptor down-regulation

Autor: A. E. Alewijnse, Martine J. Smit, Yvonne van de Vrede, Edwin Roovers, Rob Leurs, Henk Timmerman

Publikováno v: Journal of Biological Chemistry, 271(13), 7574-7582. American Society for Biochemistry and Molecular Biology Inc.
Smit, M J, Roovers, E, Timmerman, H, van de Vrede, Y, Alewijnse, A E & Leurs, R 1996, ' Two distinct pathways for histamine H2 receptor down-regulation. ', Journal of Biological Chemistry, vol. 271, no. 13, pp. 7574-7582 . https://doi.org/10.1074/jbc.271.13.7574

Pretreatment of Chinese hamster ovary cells expressing the histamine H receptor (CHOrH cells) with histamine resulted in a time-dependent (t ≈ 7 h) and dose-dependent (EC = 18 nM) H receptor down-regulation measured as [I]iodoaminopotentidine bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fa3a6db5b476ab06d2b4d3f23e414c
https://doi.org/10.1074/jbc.271.13.7574

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Characterization of a putative molluscan insulin-related peptide receptor

Autor: Rudi J. Planta, Edwin Roovers, H van Heerikhuizen, Wijnand P. M. Geraerts, E. R. Van Kesteren, Erno Vreugdenhil, M. E. Vincent

Publikováno v: Gene, 162, 181-188. Elsevier
Roovers, E, Vincent, M E, van Kesteren, E, Geraerts, W P M, Planta, R J, Vreugdenhil, E & van Heerikhuizen, H 1995, ' Characterization of a putative molluscan insulin-related peptide receptor. ', Gene, vol. 162, pp. 181-188 . https://doi.org/10.1016/0378-1119(95)00323-X

In the pond snail Lymnaea stagnalis (Ls), growth and associated processes are likely to be controlled by a family of molluscan insulin-related peptides (MIP). Here we report on the cloning of a cDNA encoding a putative receptor for these MIP. This cD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3384a4904aeb8e608c87ffd9d043a63d
https://doi.org/10.1016/0378-1119(95)00323-x

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A G-protein beta subunit that is expressed in the central nervous system of the mollusc Lymnaea stagnalis identified through cDNA cloning

Autor: Harm van Heerikhuizen, Ellen R. Van Kesteren, Rudi J. Planta, Jaco C. Knol, Edwin Roovers, Erno Vreugdenhil

Publikováno v: Biochimica et biophysica acta. 1222(1)

We have cloned cDNA encoding a G-protein beta subunit from the central nervous system (CNS) of the mollusc Lymnaea stagnalis. The deduced protein is very homologous to other metazoan beta subunits. Thus, the Lymnaea CNS can be used as a model system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a377996de6305b42fbff3ceb96993e92
https://pubmed.ncbi.nlm.nih.gov/7514444

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Autor: Rudi J. Planta, August B. Smit, Erno Vreugdenhil, J. Joosse, Edwin Roovers, Harm van Heerikhuizen, Wijnand P. M. Geraerts

Publikováno v: Biological Signal Transduction ISBN: 9783642751387

Insulin is a protein hormone with a long record in scientific research. In 1922 it was discovered that insulin is a hypoglycaemic hormone in dogs (Banting and Best, 1922). The succesful treatment of diabetes mellitus by injections of insulin is regar

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https://doi.org/10.1007/978-3-642-75136-3_5

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Chemoattractant and guanosine 5′-[γ-thio]triphosphate induce the accumulation of inositol 1,4,5-trisphosphate in Dictyostelium cells that are labelled with [3H]inositol by electroporation

Autor: Louis C. Penning, Christophe Erneux, J Van der Kaay, Edwin Roovers, P. J. M. Van Haastert, M.M. van Lookeren Campagne, M. J. De Vries

Publikováno v: Biochemical Journal. 258:577-586

The analysis of the inositol cycle in Dictyostelium discoideum cells is complicated by the limited uptake of [3H]inositol (0.2% of the applied radioactivity in 6 h), and by the conversion of [3H]inositol into water-soluble inositol metabolites that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f3de37c97e0a72368a9a627e6b0524
https://doi.org/10.1042/bj2580577

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Elektronická kniha

Activation and Desensitization of Transducing Pathways

Autor: T.M. Konijn, M.D. Houslay, P.J.M. van Haastert

Activation by and desensitization to signals originating from the environment is common in all organisms, ranging from prokaryotes to higher eukaryotes. Recently, a number of novel mechanisms involved in activation and desensitization have been eluci

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