Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Edwin R Chilvers"'
Autor:
Andrew M Wilson, Allan B Clark, Anthony Cahn, Edwin R Chilvers, William Fraser, Matthew Hammond, David M Livermore, Toby M Maher, Helen Parfrey, Ann Marie Swart, Susan Stirling, David Thickett, Moira Whyte
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 8, Iss 9 (2021)
Background: Idiopathic pulmonary fibrosis is an irreversible fibrosing lung disorder with a poor prognosis. Current treatments slow the rate of decline in lung function and may influence survival, but they have a significant side-effect profile and s
Externí odkaz:
https://doaj.org/article/eac2fcbe27b44ad5b2fc818f25be3374
Autor:
Nicole Toepfner, Christoph Herold, Oliver Otto, Philipp Rosendahl, Angela Jacobi, Martin Kräter, Julia Stächele, Leonhard Menschner, Maik Herbig, Laura Ciuffreda, Lisa Ranford-Cartwright, Michal Grzybek, Ünal Coskun, Elisabeth Reithuber, Geneviève Garriss, Peter Mellroth, Birgitta Henriques-Normark, Nicola Tregay, Meinolf Suttorp, Martin Bornhäuser, Edwin R Chilvers, Reinhard Berner, Jochen Guck
Publikováno v:
eLife, Vol 7 (2018)
Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all maj
Externí odkaz:
https://doaj.org/article/86b96256276f42619ec6a394f2c8b4ff
Publikováno v:
eLife, Vol 6 (2017)
Systemic vascular pressure in vertebrates is regulated by a range of factors: one key element of control is peripheral resistance in tissue capillary beds. Many aspects of the relationship between central control of vascular flow and peripheral resis
Externí odkaz:
https://doaj.org/article/ac2ab09002c2460bb2b49bb59433a56b
Autor:
Christine A Fiddler, Helen Parfrey, Andrew S Cowburn, Ding Luo, Gerard B Nash, Gillian Murphy, Edwin R Chilvers
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0160108 (2016)
Aminopeptidase N (CD13) is a widely expressed cell surface metallopeptidase involved in the migration of cancer and endothelial cells. Apart from our demonstration that CD13 modulates the efficacy of tumor necrosis factor-α-induced apoptosis in neut
Externí odkaz:
https://doaj.org/article/82265c23db2648bea5382b96c4e44413
Autor:
Jatinder K Juss, Richard P Hayhoe, Charles E Owen, Ian Bruce, Sarah R Walmsley, Andrew S Cowburn, Suhasini Kulkarni, Keith B Boyle, Len Stephens, Phillip T Hawkins, Edwin R Chilvers, Alison M Condliffe
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45933 (2012)
We have investigated the contribution of individual phosphoinositide 3-kinase (PI3K) Class I isoforms to the regulation of neutrophil survival using (i) a panel of commercially available small molecule isoform-selective PI3K Class I inhibitors, (ii)
Externí odkaz:
https://doaj.org/article/b74aab3989124dae8e5cc3a0babdf320
Autor:
Andrew E Ekpenyong, Graeme Whyte, Kevin Chalut, Stefano Pagliara, Franziska Lautenschläger, Christine Fiddler, Stephan Paschke, Ulrich F Keyser, Edwin R Chilvers, Jochen Guck
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45237 (2012)
Although cellular mechanical properties are known to alter during stem cell differentiation, understanding of the functional relevance of such alterations is incomplete. Here, we show that during the course of differentiation of human myeloid precurs
Externí odkaz:
https://doaj.org/article/5f17c200369246a8865fa2fe27e005a9
Autor:
Katharine M. Lodge, Arlette Vassallo, Bin Liu, Merete Long, Zhen Tong, Paul R. Newby, Danya Agha-Jaffar, Koralia Paschalaki, Clara E. Green, Kylie B. R. Belchamber, Victoria C. Ridger, Robert A. Stockley, Elizabeth Sapey, Charlotte Summers, Andrew S. Cowburn, Edwin R. Chilvers, Wei Li, Alison M. Condliffe
Publikováno v:
American journal of respiratory and critical care medicine. 205(8)
Rationale: Patients with chronic obstructive pulmonary disease (COPD) experience excess cardiovascular morbidity and mortality, and exacerbations further increase the risk of such events. COPD is associated with persistent blood and airway neutrophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fd848c176ef31f32c61629c9f1bb85
https://pubmed.ncbi.nlm.nih.gov/35148486
https://pubmed.ncbi.nlm.nih.gov/35148486
Autor:
Moira K. B. Whyte, Toby M. Maher, Ann Marie Swart, Allan Clark, Susan Stirling, Matthew Hammond, David R Thickett, Edwin R. Chilvers, William D. Fraser, Andrew M. Wilson, Anthony Cahn, David M. Livermore, Helen Parfrey
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 8, Iss 9 (2021)
BackgroundIdiopathic pulmonary fibrosis is an irreversible fibrosing lung disorder with a poor prognosis. Current treatments slow the rate of decline in lung function and may influence survival, but they have a significant side-effect profile and so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd62ec9168450bbe7ec41056815318a
https://doaj.org/article/eac2fcbe27b44ad5b2fc818f25be3374
https://doaj.org/article/eac2fcbe27b44ad5b2fc818f25be3374
Autor:
Emily Jarvis, A. Michael Peters, Kathryn Povey, Anthony Cahn, Daniel Gillett, Marius de Groot, Glyn Bradley, Edwin R. Chilvers, Fred Wilson, Mark Lennon, Rosalind Simmonds, Joanna Maison, Edith M. Hessel, Chandra K. Solanki, Malcolm Begg, Judith Babar, Nicola Tregay, Anna Wong, Neda Farahi, Sujith Madhavan
Publikováno v:
Thorax
RationaleThere is a need to develop imaging protocols which assess neutrophilic inflammation in the lung.AimTo quantify whole lung neutrophil accumulation in (1) healthy volunteers (HV) following inhaled lipopolysaccharide (LPS) or saline and (2) pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cde5d808e499479d63ccccb0a332b6c
http://europepmc.org/articles/PMC6585304
http://europepmc.org/articles/PMC6585304