Výsledky vyhledávání - "Edwin R, Parra Cuentas"

Data from Efficacy, Safety, and Biomarker Analysis of Combined PD-L1 (Atezolizumab) and VEGF (Bevacizumab) Blockade in Advanced Malignant Peritoneal Mesothelioma

Malignant peritoneal mesothelioma (MPeM) is a rare but aggressive malignancy with limited treatment options. VEGF inhibition enhances efficacy of immune-checkpoint inhibitors by reworking the immunosuppressive tumor milieu. Efficacy and safety of com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810c1697e03dca3033be01a2d214aa5c
https://doi.org/10.1158/2159-8290.c.6549433.v1

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Data from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

STK11/LKB1 is among the most commonly inactivated tumor suppressors in non–small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes promote immune escape, undermining the effectiveness of immunotherapies, but it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30038180153fb5c0a6ab7e879559e39e
https://doi.org/10.1158/0008-5472.c.6507878.v1

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Supplementary method figure from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

This file contains flow cytometry gating strategy used for the analysis of mouse tumors and surface markers for the immune cells described in the manuscript.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acbf150e81fe94096555956c8accf51
https://doi.org/10.1158/0008-5472.22409924

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Supplementary methods from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

This file contains detailed information about the methods in the manuscript. These include: a list of clone names for all the antibodies, gating method for FACS analysis and sorting, method for mouse RNA sequencing data analysis and human gene expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4ee37031eefa3b15d42c3d15bfc669
https://doi.org/10.1158/0008-5472.22409921.v1

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Supplementary figure legends from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

This file contains information regarding the figure legends and detailed description for the supplementary figures.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c766c58949277d7cbe91a590e30573e
https://doi.org/10.1158/0008-5472.22409933.v1

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Supplemental Figures from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

This file contains figures which include: additional immune proofing data of mouse tumors, RNA sequencing data of neutrophils, cytokine and chemokine profile of Kras, p53, LKB1/STK11 mutant cell lines, data for neutrophil depletion, chemokine and cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205e19061918c477c93290b8835212bd
https://doi.org/10.1158/0008-5472.22409936

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Comprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk

Publikováno v: British journal of cancer. 127(7)

Ductal carcinoma in situ (DCIS) is treated to prevent subsequent ipsilateral invasive breast cancer (iIBC). However, many DCIS lesions will never become invasive. To prevent overtreatment, we need to distinguish harmless from potentially hazardous DC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee2c8544327a38ccc8865101644c501f
https://pubmed.ncbi.nlm.nih.gov/35768550

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Abstract 515: Single-cell transcriptomic analysis of HR+/HER2- breast cancer identifies gene signatures that predict outcomes of luminal A and B subtypes

Autor: Sofia Mastoraki, Jerome Lin, Xiayu Rao, Sophie R. Liu, Harsh Batra, Maria G. Raso, Edwin R. Parra Cuentas, Akshara S. Raghavendra, Komal S. Rasaputra, Min Yi, Jing Wang, Aysegul Sahin, Debasish Tripathy, Kelly K. Hunt, Nicholas E. Navin, Khandan Keyomarsi

Publikováno v: Cancer Research. 82:515-515

Introduction: Patients with luminal A and B early-stage ER+/HER2- breast cancer (BrCa) are uniformly treated with adjuvant endocrine therapy (ET) (±chemotherapy). A better understanding of drivers of ET resistance is required as subsequent lethal me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c12f14802376867bbb1bb0935638849
https://doi.org/10.1158/1538-7445.am2022-515

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